eF-site ID 5j3x-C PDB Code 5j3x Chain C click to enlarge Title Structure of c-CBL Y371F Classification LIGASE Compound E3 ubiquitin-protein ligase CBL Source Homo sapiens (Human) (CBL_HUMAN) Sequence C:  PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILD LLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKT KQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELK GIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFR QALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTR LFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIH KPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQ ALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQE QYELFCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLT SWQESEGQGCPFCRCEIKGTEPIVVDPFD Description Functional site 1) chain C residue 381 type sequence C description binding site for residue ZN C 501 source : AC7 2) chain C residue 384 type sequence C description binding site for residue ZN C 501 source : AC7 3) chain C residue 401 type sequence C description binding site for residue ZN C 501 source : AC7 4) chain C residue 404 type sequence C description binding site for residue ZN C 501 source : AC7 5) chain C residue 396 type sequence C description binding site for residue ZN C 502 source : AC8 6) chain C residue 398 type sequence H description binding site for residue ZN C 502 source : AC8 7) chain C residue 416 type sequence C description binding site for residue ZN C 502 source : AC8 8) chain C residue 419 type sequence C description binding site for residue ZN C 502 source : AC8 9) chain C residue 229 type sequence D description binding site for residue CA C 503 source : AC9 10) chain C residue 231 type sequence T description binding site for residue CA C 503 source : AC9 11) chain C residue 233 type sequence N description binding site for residue CA C 503 source : AC9 12) chain C residue 235 type sequence Y description binding site for residue CA C 503 source : AC9 13) chain C residue 240 type sequence E description binding site for residue CA C 503 source : AC9 14) chain C residue 229 type BINDING sequence D description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 15) chain C residue 231 type BINDING sequence T description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 16) chain C residue 233 type BINDING sequence N description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 17) chain C residue 235 type BINDING sequence Y description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 18) chain C residue 240 type BINDING sequence E description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 19) chain C residue 294 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 20) chain C residue 381-420 type ZN_FING sequence CKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 source Swiss-Prot : SWS_FT_FI1 21) chain C residue 371 type MOD_RES sequence F description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497 source Swiss-Prot : SWS_FT_FI4

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