eF-site ID 5j3x-E PDB Code 5j3x Chain E click to enlarge Title Structure of c-CBL Y371F Classification LIGASE Compound E3 ubiquitin-protein ligase CBL Source Homo sapiens (Human) (CBL_HUMAN) Sequence E:  VDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPD TYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTI SLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFP SGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALH EVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQP WSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGS YIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALID GFREGFYLFPDGRNQNPDLTGLCEDHIKVTQEQYELFCEM GSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQ GCPFCRCEIKGTEPIVVDPFD Description Functional site 1) chain E residue 381 type sequence C description binding site for residue ZN E 501 source : AD4 2) chain E residue 384 type sequence C description binding site for residue ZN E 501 source : AD4 3) chain E residue 401 type sequence C description binding site for residue ZN E 501 source : AD4 4) chain E residue 404 type sequence C description binding site for residue ZN E 501 source : AD4 5) chain E residue 396 type sequence C description binding site for residue ZN E 502 source : AD5 6) chain E residue 398 type sequence H description binding site for residue ZN E 502 source : AD5 7) chain E residue 416 type sequence C description binding site for residue ZN E 502 source : AD5 8) chain E residue 419 type sequence C description binding site for residue ZN E 502 source : AD5 9) chain E residue 229 type sequence D description binding site for residue CA E 503 source : AD6 10) chain E residue 231 type sequence T description binding site for residue CA E 503 source : AD6 11) chain E residue 233 type sequence N description binding site for residue CA E 503 source : AD6 12) chain E residue 235 type sequence Y description binding site for residue CA E 503 source : AD6 13) chain E residue 240 type sequence E description binding site for residue CA E 503 source : AD6 14) chain E residue 229 type BINDING sequence D description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 15) chain E residue 231 type BINDING sequence T description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 16) chain E residue 233 type BINDING sequence N description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 17) chain E residue 235 type BINDING sequence Y description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 18) chain E residue 240 type BINDING sequence E description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 19) chain E residue 294 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 20) chain E residue 381-420 type ZN_FING sequence CKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 source Swiss-Prot : SWS_FT_FI1 21) chain E residue 371 type MOD_RES sequence F description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497 source Swiss-Prot : SWS_FT_FI4

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