eF-site ID 5j3x-D PDB Code 5j3x Chain D click to enlarge Title Structure of c-CBL Y371F Classification LIGASE Compound E3 ubiquitin-protein ligase CBL Source Homo sapiens (Human) (CBL_HUMAN) Sequence D:  PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILD LLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKT KQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELK GIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFR QALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTR LFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIH KPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQ ALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQE QYELFCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLT SWQESEGQGCPFCRCEIKGTEPIVVDPFD Description Functional site 1) chain D residue 381 type sequence C description binding site for residue ZN D 501 source : AD1 2) chain D residue 384 type sequence C description binding site for residue ZN D 501 source : AD1 3) chain D residue 401 type sequence C description binding site for residue ZN D 501 source : AD1 4) chain D residue 404 type sequence C description binding site for residue ZN D 501 source : AD1 5) chain D residue 396 type sequence C description binding site for residue ZN D 502 source : AD2 6) chain D residue 398 type sequence H description binding site for residue ZN D 502 source : AD2 7) chain D residue 416 type sequence C description binding site for residue ZN D 502 source : AD2 8) chain D residue 419 type sequence C description binding site for residue ZN D 502 source : AD2 9) chain D residue 229 type sequence D description binding site for residue CA D 503 source : AD3 10) chain D residue 231 type sequence T description binding site for residue CA D 503 source : AD3 11) chain D residue 233 type sequence N description binding site for residue CA D 503 source : AD3 12) chain D residue 235 type sequence Y description binding site for residue CA D 503 source : AD3 13) chain D residue 240 type sequence E description binding site for residue CA D 503 source : AD3 14) chain D residue 381-420 type ZN_FING sequence CKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 source Swiss-Prot : SWS_FT_FI1 15) chain D residue 229 type BINDING sequence D description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 16) chain D residue 231 type BINDING sequence T description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 17) chain D residue 233 type BINDING sequence N description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 18) chain D residue 235 type BINDING sequence Y description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 19) chain D residue 240 type BINDING sequence E description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 20) chain D residue 371 type MOD_RES sequence F description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497 source Swiss-Prot : SWS_FT_FI4 21) chain D residue 294 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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