eF-site ID 5j3x-ABCDEF
PDB Code 5j3x
Chain A, B, C, D, E, F

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Title Structure of c-CBL Y371F
Classification LIGASE
Compound E3 ubiquitin-protein ligase CBL
Source Homo sapiens (Human) (CBL_HUMAN)
Sequence A:  PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILD
LLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKT
KQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELK
GIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFR
QALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTR
LFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIH
KPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQ
ALIDGFREGFYLFPDGRNQNPDLTGLCEPTHIKVTQEQYE
LFCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQ
ESEGQGCPFCRCEIKGTEPIVVDPFD
B:  PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILD
LLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKT
KQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELK
GIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFR
QALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTR
LFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIH
KPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQ
ALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQE
QYELFCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLT
SWQESEGQGCPFCRCEIKGTEPIVVDPFD
C:  PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILD
LLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKT
KQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELK
GIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFR
QALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTR
LFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIH
KPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQ
ALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQE
QYELFCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLT
SWQESEGQGCPFCRCEIKGTEPIVVDPFD
D:  PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILD
LLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKT
KQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELK
GIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFR
QALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTR
LFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIH
KPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQ
ALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQE
QYELFCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLT
SWQESEGQGCPFCRCEIKGTEPIVVDPFD
E:  VDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPD
TYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTI
SLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFP
SGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALH
EVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQP
WSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGS
YIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALID
GFREGFYLFPDGRNQNPDLTGLCEDHIKVTQEQYELFCEM
GSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQ
GCPFCRCEIKGTEPIVVDPFD
F:  TVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLP
DTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQT
ISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIF
PSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQAL
HEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQ
PWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPG
SYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALI
DGFREGFYLFPDGRNQNPDLTGLCEPTDHIKVTQEQYELF
CEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQES
EGQGCPFCRCEIKGTEPIVVDPFD
Description


Functional site

1) chain A
residue 381
type
sequence C
description binding site for residue ZN A 501
source : AC1

2) chain A
residue 384
type
sequence C
description binding site for residue ZN A 501
source : AC1

3) chain A
residue 401
type
sequence C
description binding site for residue ZN A 501
source : AC1

4) chain A
residue 404
type
sequence C
description binding site for residue ZN A 501
source : AC1

5) chain A
residue 396
type
sequence C
description binding site for residue ZN A 502
source : AC2

6) chain A
residue 398
type
sequence H
description binding site for residue ZN A 502
source : AC2

7) chain A
residue 416
type
sequence C
description binding site for residue ZN A 502
source : AC2

8) chain A
residue 419
type
sequence C
description binding site for residue ZN A 502
source : AC2

9) chain A
residue 229
type
sequence D
description binding site for residue CA A 503
source : AC3

10) chain A
residue 231
type
sequence T
description binding site for residue CA A 503
source : AC3

11) chain A
residue 233
type
sequence N
description binding site for residue CA A 503
source : AC3

12) chain A
residue 235
type
sequence Y
description binding site for residue CA A 503
source : AC3

13) chain A
residue 240
type
sequence E
description binding site for residue CA A 503
source : AC3

14) chain B
residue 381
type
sequence C
description binding site for residue ZN B 501
source : AC4

15) chain B
residue 384
type
sequence C
description binding site for residue ZN B 501
source : AC4

16) chain B
residue 401
type
sequence C
description binding site for residue ZN B 501
source : AC4

17) chain B
residue 404
type
sequence C
description binding site for residue ZN B 501
source : AC4

18) chain B
residue 396
type
sequence C
description binding site for residue ZN B 502
source : AC5

19) chain B
residue 398
type
sequence H
description binding site for residue ZN B 502
source : AC5

20) chain B
residue 416
type
sequence C
description binding site for residue ZN B 502
source : AC5

21) chain B
residue 419
type
sequence C
description binding site for residue ZN B 502
source : AC5

22) chain B
residue 229
type
sequence D
description binding site for residue CA B 503
source : AC6

23) chain B
residue 231
type
sequence T
description binding site for residue CA B 503
source : AC6

24) chain B
residue 233
type
sequence N
description binding site for residue CA B 503
source : AC6

25) chain B
residue 235
type
sequence Y
description binding site for residue CA B 503
source : AC6

26) chain B
residue 240
type
sequence E
description binding site for residue CA B 503
source : AC6

27) chain C
residue 381
type
sequence C
description binding site for residue ZN C 501
source : AC7

28) chain C
residue 384
type
sequence C
description binding site for residue ZN C 501
source : AC7

29) chain C
residue 401
type
sequence C
description binding site for residue ZN C 501
source : AC7

30) chain C
residue 404
type
sequence C
description binding site for residue ZN C 501
source : AC7

31) chain C
residue 396
type
sequence C
description binding site for residue ZN C 502
source : AC8

32) chain C
residue 398
type
sequence H
description binding site for residue ZN C 502
source : AC8

33) chain C
residue 416
type
sequence C
description binding site for residue ZN C 502
source : AC8

34) chain C
residue 419
type
sequence C
description binding site for residue ZN C 502
source : AC8

35) chain C
residue 229
type
sequence D
description binding site for residue CA C 503
source : AC9

36) chain C
residue 231
type
sequence T
description binding site for residue CA C 503
source : AC9

37) chain C
residue 233
type
sequence N
description binding site for residue CA C 503
source : AC9

38) chain C
residue 235
type
sequence Y
description binding site for residue CA C 503
source : AC9

39) chain C
residue 240
type
sequence E
description binding site for residue CA C 503
source : AC9

40) chain D
residue 381
type
sequence C
description binding site for residue ZN D 501
source : AD1

41) chain D
residue 384
type
sequence C
description binding site for residue ZN D 501
source : AD1

42) chain D
residue 401
type
sequence C
description binding site for residue ZN D 501
source : AD1

43) chain D
residue 404
type
sequence C
description binding site for residue ZN D 501
source : AD1

44) chain D
residue 396
type
sequence C
description binding site for residue ZN D 502
source : AD2

45) chain D
residue 398
type
sequence H
description binding site for residue ZN D 502
source : AD2

46) chain D
residue 416
type
sequence C
description binding site for residue ZN D 502
source : AD2

47) chain D
residue 419
type
sequence C
description binding site for residue ZN D 502
source : AD2

48) chain D
residue 229
type
sequence D
description binding site for residue CA D 503
source : AD3

49) chain D
residue 231
type
sequence T
description binding site for residue CA D 503
source : AD3

50) chain D
residue 233
type
sequence N
description binding site for residue CA D 503
source : AD3

51) chain D
residue 235
type
sequence Y
description binding site for residue CA D 503
source : AD3

52) chain D
residue 240
type
sequence E
description binding site for residue CA D 503
source : AD3

53) chain E
residue 381
type
sequence C
description binding site for residue ZN E 501
source : AD4

54) chain E
residue 384
type
sequence C
description binding site for residue ZN E 501
source : AD4

55) chain E
residue 401
type
sequence C
description binding site for residue ZN E 501
source : AD4

56) chain E
residue 404
type
sequence C
description binding site for residue ZN E 501
source : AD4

57) chain E
residue 396
type
sequence C
description binding site for residue ZN E 502
source : AD5

58) chain E
residue 398
type
sequence H
description binding site for residue ZN E 502
source : AD5

59) chain E
residue 416
type
sequence C
description binding site for residue ZN E 502
source : AD5

60) chain E
residue 419
type
sequence C
description binding site for residue ZN E 502
source : AD5

61) chain E
residue 229
type
sequence D
description binding site for residue CA E 503
source : AD6

62) chain E
residue 231
type
sequence T
description binding site for residue CA E 503
source : AD6

63) chain E
residue 233
type
sequence N
description binding site for residue CA E 503
source : AD6

64) chain E
residue 235
type
sequence Y
description binding site for residue CA E 503
source : AD6

65) chain E
residue 240
type
sequence E
description binding site for residue CA E 503
source : AD6

66) chain F
residue 381
type
sequence C
description binding site for residue ZN F 501
source : AD7

67) chain F
residue 384
type
sequence C
description binding site for residue ZN F 501
source : AD7

68) chain F
residue 401
type
sequence C
description binding site for residue ZN F 501
source : AD7

69) chain F
residue 404
type
sequence C
description binding site for residue ZN F 501
source : AD7

70) chain F
residue 396
type
sequence C
description binding site for residue ZN F 502
source : AD8

71) chain F
residue 398
type
sequence H
description binding site for residue ZN F 502
source : AD8

72) chain F
residue 416
type
sequence C
description binding site for residue ZN F 502
source : AD8

73) chain F
residue 419
type
sequence C
description binding site for residue ZN F 502
source : AD8

74) chain F
residue 229
type
sequence D
description binding site for residue CA F 503
source : AD9

75) chain F
residue 231
type
sequence T
description binding site for residue CA F 503
source : AD9

76) chain F
residue 233
type
sequence N
description binding site for residue CA F 503
source : AD9

77) chain F
residue 235
type
sequence Y
description binding site for residue CA F 503
source : AD9

78) chain F
residue 240
type
sequence E
description binding site for residue CA F 503
source : AD9

79) chain A
residue 381-420
type ZN_FING
sequence CKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR
description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175
source Swiss-Prot : SWS_FT_FI1

80) chain B
residue 381-420
type ZN_FING
sequence CKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR
description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175
source Swiss-Prot : SWS_FT_FI1

81) chain C
residue 381-420
type ZN_FING
sequence CKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR
description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175
source Swiss-Prot : SWS_FT_FI1

82) chain D
residue 381-420
type ZN_FING
sequence CKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR
description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175
source Swiss-Prot : SWS_FT_FI1

83) chain E
residue 381-420
type ZN_FING
sequence CKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR
description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175
source Swiss-Prot : SWS_FT_FI1

84) chain F
residue 381-420
type ZN_FING
sequence CKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR
description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175
source Swiss-Prot : SWS_FT_FI1

85) chain A
residue 229
type BINDING
sequence D
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

86) chain B
residue 240
type BINDING
sequence E
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

87) chain C
residue 229
type BINDING
sequence D
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

88) chain C
residue 231
type BINDING
sequence T
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

89) chain C
residue 233
type BINDING
sequence N
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

90) chain C
residue 235
type BINDING
sequence Y
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

91) chain C
residue 240
type BINDING
sequence E
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

92) chain D
residue 229
type BINDING
sequence D
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

93) chain D
residue 231
type BINDING
sequence T
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

94) chain D
residue 233
type BINDING
sequence N
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

95) chain D
residue 235
type BINDING
sequence Y
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

96) chain A
residue 231
type BINDING
sequence T
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

97) chain D
residue 240
type BINDING
sequence E
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

98) chain E
residue 229
type BINDING
sequence D
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

99) chain E
residue 231
type BINDING
sequence T
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

100) chain E
residue 233
type BINDING
sequence N
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

101) chain E
residue 235
type BINDING
sequence Y
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

102) chain E
residue 240
type BINDING
sequence E
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

103) chain F
residue 229
type BINDING
sequence D
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

104) chain F
residue 231
type BINDING
sequence T
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

105) chain F
residue 233
type BINDING
sequence N
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

106) chain F
residue 235
type BINDING
sequence Y
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

107) chain A
residue 233
type BINDING
sequence N
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

108) chain F
residue 240
type BINDING
sequence E
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

109) chain A
residue 235
type BINDING
sequence Y
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

110) chain A
residue 240
type BINDING
sequence E
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

111) chain B
residue 229
type BINDING
sequence D
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

112) chain B
residue 231
type BINDING
sequence T
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

113) chain B
residue 233
type BINDING
sequence N
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

114) chain B
residue 235
type BINDING
sequence Y
description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL
source Swiss-Prot : SWS_FT_FI2

115) chain A
residue 371
type MOD_RES
sequence F
description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497
source Swiss-Prot : SWS_FT_FI4

116) chain B
residue 371
type MOD_RES
sequence F
description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497
source Swiss-Prot : SWS_FT_FI4

117) chain C
residue 371
type MOD_RES
sequence F
description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497
source Swiss-Prot : SWS_FT_FI4

118) chain D
residue 371
type MOD_RES
sequence F
description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497
source Swiss-Prot : SWS_FT_FI4

119) chain E
residue 371
type MOD_RES
sequence F
description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497
source Swiss-Prot : SWS_FT_FI4

120) chain F
residue 371
type MOD_RES
sequence F
description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497
source Swiss-Prot : SWS_FT_FI4

121) chain A
residue 294
type BINDING
sequence R
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

122) chain B
residue 294
type BINDING
sequence R
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

123) chain C
residue 294
type BINDING
sequence R
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

124) chain D
residue 294
type BINDING
sequence R
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

125) chain E
residue 294
type BINDING
sequence R
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

126) chain F
residue 294
type BINDING
sequence R
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

127) chain A
residue 396-405
type prosite
sequence CGHLMCTSCL
description ZF_RING_1 Zinc finger RING-type signature. CgHlMCtsCL
source prosite : PS00518


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