eF-site ID 5iz7-ABCDEF PDB Code 5iz7 Chain A, B, C, D, E, F click to enlarge Title Cryo-EM structure of thermally stable Zika virus strain H/PF/2013 Classification VIRUS Compound structural protein E Source ORGANISM_COMMON: ZIKV; ORGANISM_SCIENTIFIC: Zika virus; Sequence A:  IRCIGVSNRDFVEGMSGGTWVDVVLEHGGCVTVMAQDKPT VDIELVTTTVSNMAEVRSYCYEASISDMASDSRCPTQGEA YLDKQSDTQYVCKRTLVDRGWGNGCGLFGKGSLVTCAKFA CSKKMTGKSIQPENLEYRIMLSVHGSQHSGMIVNDTGHET DENRAKVEITPNSPRAEATLGGFGSLGLDCEPRTGLDFSD LYYLTMNNKHWLVHKEWFHDIPLPWHAGADTGTPHWNNKE ALVEFKDAHAKRQTVVVLGSQEGAVHTALAGALEAEMDGA KGRLSSGHLKCRLKMDKLRLKGVSYSLCTAAFTFTKIPAE TLHGTVTVEVQYAGTDGPCKVPAQMAVDMQTLTPVGRLIT ANPVITESTENSKMMLELDPPFGDSYIVIGVGEKKITHHW HRSGSTIGKAFEATVRGAKRMAVLGDTAWDFGSVGGALNS LGKGIHQIFGAAFKSLFGGMSWFSQILIGTLLMWLGLNTK NGSISLMCLALGGVLIFLSTAVSA B:  IRCIGVSNRDFVEGMSGGTWVDVVLEHGGCVTVMAQDKPT VDIELVTTTVSNMAEVRSYCYEASISDMASDSRCPTQGEA YLDKQSDTQYVCKRTLVDRGWGNGCGLFGKGSLVTCAKFA CSKKMTGKSIQPENLEYRIMLSVHGSQHSGMIVNDTGHET DENRAKVEITPNSPRAEATLGGFGSLGLDCEPRTGLDFSD LYYLTMNNKHWLVHKEWFHDIPLPWHAGADTGTPHWNNKE ALVEFKDAHAKRQTVVVLGSQEGAVHTALAGALEAEMDGA KGRLSSGHLKCRLKMDKLRLKGVSYSLCTAAFTFTKIPAE TLHGTVTVEVQYAGTDGPCKVPAQMAVDMQTLTPVGRLIT ANPVITESTENSKMMLELDPPFGDSYIVIGVGEKKITHHW HRSGSTIGKAFEATVRGAKRMAVLGDTAWDFGSVGGALNS LGKGIHQIFGAAFKSLFGGMSWFSQILIGTLLMWLGLNTK NGSISLMCLALGGVLIFLSTAVSA C:  IRCIGVSNRDFVEGMSGGTWVDVVLEHGGCVTVMAQDKPT VDIELVTTTVSNMAEVRSYCYEASISDMASDSRCPTQGEA YLDKQSDTQYVCKRTLVDRGWGNGCGLFGKGSLVTCAKFA CSKKMTGKSIQPENLEYRIMLSVHGSQHSGMIVNDTGHET DENRAKVEITPNSPRAEATLGGFGSLGLDCEPRTGLDFSD LYYLTMNNKHWLVHKEWFHDIPLPWHAGADTGTPHWNNKE ALVEFKDAHAKRQTVVVLGSQEGAVHTALAGALEAEMDGA KGRLSSGHLKCRLKMDKLRLKGVSYSLCTAAFTFTKIPAE TLHGTVTVEVQYAGTDGPCKVPAQMAVDMQTLTPVGRLIT ANPVITESTENSKMMLELDPPFGDSYIVIGVGEKKITHHW HRSGSTIGKAFEATVRGAKRMAVLGDTAWDFGSVGGALNS LGKGIHQIFGAAFKSLFGGMSWFSQILIGTLLMWLGLNTK NGSISLMCLALGGVLIFLSTAVSA D:  AVTLPSHSTRKLQTRSQTWLESREYTKHLIRVENWIFRNP GFALAAAAIAWLLGSSTSQKVIYLVMILLIAPAYS E:  AVTLPSHSTRKLQTRSQTWLESREYTKHLIRVENWIFRNP GFALAAAAIAWLLGSSTSQKVIYLVMILLIAPAYS F:  AVTLPSHSTRKLQTRSQTWLESREYTKHLIRVENWIFRNP GFALAAAAIAWLLGSSTSQKVIYLVMILLIAPAYS Description (1)  structural protein E, structural protein M Functional site 1) chain D residue 35-54 type TRANSMEM sequence WIFRNPGFALAAAAIAWLLG description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 2) chain E residue 35-54 type TRANSMEM sequence WIFRNPGFALAAAAIAWLLG description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 3) chain F residue 35-54 type TRANSMEM sequence WIFRNPGFALAAAAIAWLLG description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 4) chain D residue 55-59 type TOPO_DOM sequence SSTSQ description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI2 5) chain E residue 55-59 type TOPO_DOM sequence SSTSQ description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI2 6) chain F residue 55-59 type TOPO_DOM sequence SSTSQ description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI2 7) chain C residue 484-504 type TOPO_DOM sequence ISLMCLALGGVLIFLSTAVSA description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI2 8) chain B residue 456-477 type TOPO_DOM sequence LFGGMSWFSQILIGTLLMWLGL description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI2 9) chain B residue 484-504 type TOPO_DOM sequence ISLMCLALGGVLIFLSTAVSA description Cytoplasmic => ECO:0000305 source Swiss-Prot : SWS_FT_FI2 10) chain D residue 60-75 type TRANSMEM sequence KVIYLVMILLIAPAYS description Helical => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 11) chain E residue 60-75 type TRANSMEM sequence KVIYLVMILLIAPAYS description Helical => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 12) chain F residue 60-75 type TRANSMEM sequence KVIYLVMILLIAPAYS description Helical => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 13) chain D residue 75 type SITE sequence S description Cleavage; by host signal peptidase => ECO:0000250|UniProtKB:P06935 source Swiss-Prot : SWS_FT_FI4 14) chain E residue 75 type SITE sequence S description Cleavage; by host signal peptidase => ECO:0000250|UniProtKB:P06935 source Swiss-Prot : SWS_FT_FI4 15) chain F residue 75 type SITE sequence S description Cleavage; by host signal peptidase => ECO:0000250|UniProtKB:P06935 source Swiss-Prot : SWS_FT_FI4 16) chain A residue 154 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000269|PubMed:27093288, ECO:0000269|PubMed:27338953, ECO:0000269|PubMed:27882950, ECO:0000269|PubMed:29091758 source Swiss-Prot : SWS_FT_FI5 17) chain C residue 154 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000269|PubMed:27093288, ECO:0000269|PubMed:27338953, ECO:0000269|PubMed:27882950, ECO:0000269|PubMed:29091758 source Swiss-Prot : SWS_FT_FI5 18) chain B residue 154 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000269|PubMed:27093288, ECO:0000269|PubMed:27338953, ECO:0000269|PubMed:27882950, ECO:0000269|PubMed:29091758 source Swiss-Prot : SWS_FT_FI5 19) chain B residue 38 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:A0A142I5B9 source Swiss-Prot : SWS_FT_FI6 20) chain B residue 281 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:A0A142I5B9 source Swiss-Prot : SWS_FT_FI6 21) chain A residue 281 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:A0A142I5B9 source Swiss-Prot : SWS_FT_FI6 22) chain C residue 38 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:A0A142I5B9 source Swiss-Prot : SWS_FT_FI6 23) chain C residue 281 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:A0A142I5B9 source Swiss-Prot : SWS_FT_FI6 24) chain A residue 38 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:A0A142I5B9 source Swiss-Prot : SWS_FT_FI6

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