eF-site ID 5irz-D PDB Code 5irz Chain D click to enlarge Title Structure of TRPV1 determined in lipid nanodisc Classification TRANSPORT PROTEIN Compound Transient receptor potential cation channel subfamily V member 1 Source (TRPV1_RAT) Sequence D:  TPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAY GPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLL VEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYY RPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQ YFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQR KEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMIL RDLCRFMFVYLVFLFGFSTAVVTLIEDGKYNSLYSTCLEL FKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNM LIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMR KAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTT Description Functional site 1) chain D residue 437 type sequence N description binding site for residue 6O8 D 801 source : AC1 2) chain D residue 440 type sequence V description binding site for residue 6O8 D 801 source : AC1 3) chain D residue 488 type sequence F description binding site for residue 6O8 D 801 source : AC1 4) chain D residue 491 type sequence R description binding site for residue 6O8 D 801 source : AC1 5) chain D residue 513 type sequence E description binding site for residue 6O8 D 801 source : AC1 6) chain D residue 516 type sequence F description binding site for residue 6O8 D 801 source : AC1 7) chain D residue 554 type sequence Y description binding site for residue 6O8 D 801 source : AC1 8) chain D residue 555 type sequence Y description binding site for residue 6O8 D 801 source : AC1 9) chain D residue 509 type sequence D description binding site for residue 6ES D 802 source : AC2 10) chain D residue 510 type sequence S description binding site for residue 6ES D 802 source : AC2 11) chain D residue 511 type sequence Y description binding site for residue 6ES D 802 source : AC2 12) chain D residue 512 type sequence S description binding site for residue 6ES D 802 source : AC2 13) chain D residue 550 type sequence T description binding site for residue 6ES D 802 source : AC2 14) chain D residue 557 type sequence R description binding site for residue 6ES D 802 source : AC2 15) chain D residue 570 type sequence E description binding site for residue 6ES D 802 source : AC2 16) chain D residue 699 type sequence L description binding site for residue 6ES D 802 source : AC2 17) chain D residue 700 type sequence Q description binding site for residue 6ES D 802 source : AC2 18) chain D residue 631 type sequence Y description binding site for residue 6OE D 803 source : AC3 19) chain D residue 655 type sequence F description binding site for residue 6OE D 804 source : AC4 20) chain D residue 453 type sequence Y description binding site for residue 6OE D 805 source : AC5 21) chain D residue 454 type sequence Y description binding site for residue 6OE D 805 source : AC5 22) chain D residue 454 type sequence Y description binding site for residue 6OE D 806 source : AC6 23) chain D residue 470 type sequence G description binding site for residue 6OE D 806 source : AC6 24) chain D residue 473 type sequence F description binding site for residue 6OE D 806 source : AC6 25) chain D residue 474 type sequence R description binding site for residue 6OE D 806 source : AC6 26) chain D residue 589 type sequence F description binding site for residue 6OE B 803 source : AD5 27) chain D residue 629 type sequence S description binding site for residue 6OE B 803 source : AD5 28) chain D residue 657 type sequence A description binding site for residue 6OE B 805 source : AD7 29) chain D residue 370 type MOD_RES sequence T description Phosphothreonine; by PKA; in vitro => ECO:0000269|PubMed:12194871 source Swiss-Prot : SWS_FT_FI10 30) chain D residue 502 type MOD_RES sequence S description Phosphoserine; by PKC/PRKCE => ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:12194871, ECO:0000269|PubMed:14630912 source Swiss-Prot : SWS_FT_FI11 31) chain D residue 433-453 type TRANSMEM sequence IFYFNFFVYCLYMIIFTAAAY description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 32) chain D residue 472-497 type TRANSMEM sequence YFRVTGEILSVSGGVYFFFRGIQYFL description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 33) chain D residue 511-531 type TRANSMEM sequence YSEILFFVQSLFMLVSVVLYF description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 34) chain D residue 536-556 type TRANSMEM sequence EYVASMVFSLAMGWTNMLYYT description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 35) chain D residue 572-599 type TRANSMEM sequence MILRDLCRFMFVYLVFLFGFSTAVVTLI description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 36) chain D residue 658-686 type TRANSMEM sequence VFIILLLAYVILTYILLLNMLIALMGETV description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 37) chain D residue 627 type CARBOHYD sequence Y description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11683872 source Swiss-Prot : SWS_FT_FI13 38) chain D residue 454-471 type TOPO_DOM sequence YRPVEGLPPYKLKNTVGD description Extracellular => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI2 39) chain D residue 532-535 type TOPO_DOM sequence SQRK description Extracellular => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI2 40) chain D residue 600-649 type TOPO_DOM sequence EDGKYNSLYSTCLELFKFTIGMGDLEF description Extracellular => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI2 41) chain D residue 498-510 type TOPO_DOM sequence QRRPSLKSLFVDS description Cytoplasmic => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI3 42) chain D residue 557-571 type TOPO_DOM sequence RGFQQMGIYAVMIEK description Cytoplasmic => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI3 43) chain D residue 627-649 type INTRAMEM sequence YNSLYSTCLELFKFTIGMGDLEF description Pore-forming => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200, ECO:0000305|PubMed:10931826 source Swiss-Prot : SWS_FT_FI4 44) chain D residue 704 type MOD_RES sequence T description Phosphothreonine => ECO:0000269|PubMed:14630912 source Swiss-Prot : SWS_FT_FI12 45) chain D residue 511 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX source Swiss-Prot : SWS_FT_FI7 46) chain D residue 550 type BINDING sequence T description BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX source Swiss-Prot : SWS_FT_FI7 47) chain D residue 557 type BINDING sequence R description BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX source Swiss-Prot : SWS_FT_FI7 48) chain D residue 646 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:Q9R186 source Swiss-Prot : SWS_FT_FI8

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