eF-site ID 5irz-BCDE PDB Code 5irz Chain B, C, D, E click to enlarge Title Structure of TRPV1 determined in lipid nanodisc Classification TRANSPORT PROTEIN Compound Transient receptor potential cation channel subfamily V member 1 Source (TRPV1_RAT) Sequence B:  TPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAY GPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLL VEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYY RPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQ YFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQR KEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMIL RDLCRFMFVYLVFLFGFSTAVVTLIEDGKYNSLYSTCLEL FKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNM LIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMR KAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTT C:  TPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAY GPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLL VEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYY RPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQ YFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQR KEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMIL RDLCRFMFVYLVFLFGFSTAVVTLIEDGKYNSLYSTCLEL FKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNM LIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMR KAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTT D:  TPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAY GPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLL VEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYY RPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQ YFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQR KEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMIL RDLCRFMFVYLVFLFGFSTAVVTLIEDGKYNSLYSTCLEL FKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNM LIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMR KAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTT E:  TPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAY GPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLL VEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYY RPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQ YFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQR KEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMIL RDLCRFMFVYLVFLFGFSTAVVTLIEDGKYNSLYSTCLEL FKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNM LIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMR KAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTT Description Functional site 1) chain D residue 437 type sequence N description binding site for residue 6O8 D 801 source : AC1 2) chain D residue 440 type sequence V description binding site for residue 6O8 D 801 source : AC1 3) chain D residue 488 type sequence F description binding site for residue 6O8 D 801 source : AC1 4) chain D residue 491 type sequence R description binding site for residue 6O8 D 801 source : AC1 5) chain D residue 513 type sequence E description binding site for residue 6O8 D 801 source : AC1 6) chain D residue 516 type sequence F description binding site for residue 6O8 D 801 source : AC1 7) chain D residue 554 type sequence Y description binding site for residue 6O8 D 801 source : AC1 8) chain D residue 555 type sequence Y description binding site for residue 6O8 D 801 source : AC1 9) chain D residue 509 type sequence D description binding site for residue 6ES D 802 source : AC2 10) chain D residue 510 type sequence S description binding site for residue 6ES D 802 source : AC2 11) chain D residue 511 type sequence Y description binding site for residue 6ES D 802 source : AC2 12) chain D residue 512 type sequence S description binding site for residue 6ES D 802 source : AC2 13) chain D residue 550 type sequence T description binding site for residue 6ES D 802 source : AC2 14) chain D residue 557 type sequence R description binding site for residue 6ES D 802 source : AC2 15) chain D residue 570 type sequence E description binding site for residue 6ES D 802 source : AC2 16) chain D residue 699 type sequence L description binding site for residue 6ES D 802 source : AC2 17) chain D residue 700 type sequence Q description binding site for residue 6ES D 802 source : AC2 18) chain D residue 631 type sequence Y description binding site for residue 6OE D 803 source : AC3 19) chain E residue 657 type sequence A description binding site for residue 6OE D 803 source : AC3 20) chain D residue 655 type sequence F description binding site for residue 6OE D 804 source : AC4 21) chain D residue 453 type sequence Y description binding site for residue 6OE D 805 source : AC5 22) chain D residue 454 type sequence Y description binding site for residue 6OE D 805 source : AC5 23) chain E residue 589 type sequence F description binding site for residue 6OE D 805 source : AC5 24) chain E residue 629 type sequence S description binding site for residue 6OE D 805 source : AC5 25) chain D residue 454 type sequence Y description binding site for residue 6OE D 806 source : AC6 26) chain D residue 470 type sequence G description binding site for residue 6OE D 806 source : AC6 27) chain D residue 473 type sequence F description binding site for residue 6OE D 806 source : AC6 28) chain D residue 474 type sequence R description binding site for residue 6OE D 806 source : AC6 29) chain E residue 437 type sequence N description binding site for residue 6O8 E 801 source : AC7 30) chain E residue 440 type sequence V description binding site for residue 6O8 E 801 source : AC7 31) chain E residue 488 type sequence F description binding site for residue 6O8 E 801 source : AC7 32) chain E residue 491 type sequence R description binding site for residue 6O8 E 801 source : AC7 33) chain E residue 513 type sequence E description binding site for residue 6O8 E 801 source : AC7 34) chain E residue 516 type sequence F description binding site for residue 6O8 E 801 source : AC7 35) chain E residue 554 type sequence Y description binding site for residue 6O8 E 801 source : AC7 36) chain E residue 555 type sequence Y description binding site for residue 6O8 E 801 source : AC7 37) chain E residue 509 type sequence D description binding site for residue 6ES E 802 source : AC8 38) chain E residue 510 type sequence S description binding site for residue 6ES E 802 source : AC8 39) chain E residue 511 type sequence Y description binding site for residue 6ES E 802 source : AC8 40) chain E residue 512 type sequence S description binding site for residue 6ES E 802 source : AC8 41) chain E residue 550 type sequence T description binding site for residue 6ES E 802 source : AC8 42) chain E residue 557 type sequence R description binding site for residue 6ES E 802 source : AC8 43) chain E residue 570 type sequence E description binding site for residue 6ES E 802 source : AC8 44) chain E residue 699 type sequence L description binding site for residue 6ES E 802 source : AC8 45) chain E residue 700 type sequence Q description binding site for residue 6ES E 802 source : AC8 46) chain E residue 655 type sequence F description binding site for residue 6OE E 803 source : AC9 47) chain C residue 589 type sequence F description binding site for residue 6OE E 804 source : AD1 48) chain C residue 629 type sequence S description binding site for residue 6OE E 804 source : AD1 49) chain E residue 453 type sequence Y description binding site for residue 6OE E 804 source : AD1 50) chain E residue 454 type sequence Y description binding site for residue 6OE E 804 source : AD1 51) chain E residue 454 type sequence Y description binding site for residue 6OE E 805 source : AD2 52) chain E residue 470 type sequence G description binding site for residue 6OE E 805 source : AD2 53) chain E residue 473 type sequence F description binding site for residue 6OE E 805 source : AD2 54) chain E residue 474 type sequence R description binding site for residue 6OE E 805 source : AD2 55) chain C residue 657 type sequence A description binding site for residue 6OE E 806 source : AD3 56) chain E residue 631 type sequence Y description binding site for residue 6OE E 806 source : AD3 57) chain B residue 509 type sequence D description binding site for residue 6ES B 802 source : AD4 58) chain B residue 510 type sequence S description binding site for residue 6ES B 802 source : AD4 59) chain B residue 511 type sequence Y description binding site for residue 6ES B 802 source : AD4 60) chain B residue 512 type sequence S description binding site for residue 6ES B 802 source : AD4 61) chain B residue 550 type sequence T description binding site for residue 6ES B 802 source : AD4 62) chain B residue 557 type sequence R description binding site for residue 6ES B 802 source : AD4 63) chain B residue 570 type sequence E description binding site for residue 6ES B 802 source : AD4 64) chain B residue 699 type sequence L description binding site for residue 6ES B 802 source : AD4 65) chain B residue 700 type sequence Q description binding site for residue 6ES B 802 source : AD4 66) chain B residue 453 type sequence Y description binding site for residue 6OE B 803 source : AD5 67) chain B residue 454 type sequence Y description binding site for residue 6OE B 803 source : AD5 68) chain D residue 589 type sequence F description binding site for residue 6OE B 803 source : AD5 69) chain D residue 629 type sequence S description binding site for residue 6OE B 803 source : AD5 70) chain B residue 454 type sequence Y description binding site for residue 6OE B 804 source : AD6 71) chain B residue 470 type sequence G description binding site for residue 6OE B 804 source : AD6 72) chain B residue 473 type sequence F description binding site for residue 6OE B 804 source : AD6 73) chain B residue 474 type sequence R description binding site for residue 6OE B 804 source : AD6 74) chain B residue 631 type sequence Y description binding site for residue 6OE B 805 source : AD7 75) chain D residue 657 type sequence A description binding site for residue 6OE B 805 source : AD7 76) chain B residue 655 type sequence F description binding site for residue 6OE B 806 source : AD8 77) chain C residue 509 type sequence D description binding site for residue 6ES C 802 source : AD9 78) chain C residue 510 type sequence S description binding site for residue 6ES C 802 source : AD9 79) chain C residue 511 type sequence Y description binding site for residue 6ES C 802 source : AD9 80) chain C residue 512 type sequence S description binding site for residue 6ES C 802 source : AD9 81) chain C residue 550 type sequence T description binding site for residue 6ES C 802 source : AD9 82) chain C residue 557 type sequence R description binding site for residue 6ES C 802 source : AD9 83) chain C residue 570 type sequence E description binding site for residue 6ES C 802 source : AD9 84) chain C residue 699 type sequence L description binding site for residue 6ES C 802 source : AD9 85) chain C residue 700 type sequence Q description binding site for residue 6ES C 802 source : AD9 86) chain B residue 589 type sequence F description binding site for residue 6OE C 803 source : AE1 87) chain B residue 629 type sequence S description binding site for residue 6OE C 803 source : AE1 88) chain C residue 453 type sequence Y description binding site for residue 6OE C 803 source : AE1 89) chain C residue 454 type sequence Y description binding site for residue 6OE C 803 source : AE1 90) chain C residue 454 type sequence Y description binding site for residue 6OE C 804 source : AE2 91) chain C residue 470 type sequence G description binding site for residue 6OE C 804 source : AE2 92) chain C residue 473 type sequence F description binding site for residue 6OE C 804 source : AE2 93) chain C residue 474 type sequence R description binding site for residue 6OE C 804 source : AE2 94) chain B residue 657 type sequence A description binding site for residue 6OE C 805 source : AE3 95) chain C residue 631 type sequence Y description binding site for residue 6OE C 805 source : AE3 96) chain C residue 655 type sequence F description binding site for residue 6OE C 806 source : AE4 97) chain B residue 437 type sequence N description binding site for Di-peptide 6O8 B 801 and ARG B 491 source : AE5 98) chain B residue 440 type sequence V description binding site for Di-peptide 6O8 B 801 and ARG B 491 source : AE5 99) chain B residue 487 type sequence Y description binding site for Di-peptide 6O8 B 801 and ARG B 491 source : AE5 100) chain B residue 488 type sequence F description binding site for Di-peptide 6O8 B 801 and ARG B 491 source : AE5 101) chain B residue 489 type sequence F description binding site for Di-peptide 6O8 B 801 and ARG B 491 source : AE5 102) chain B residue 490 type sequence F description binding site for Di-peptide 6O8 B 801 and ARG B 491 source : AE5 103) chain B residue 492 type sequence G description binding site for Di-peptide 6O8 B 801 and ARG B 491 source : AE5 104) chain B residue 493 type sequence I description binding site for Di-peptide 6O8 B 801 and ARG B 491 source : AE5 105) chain B residue 494 type sequence Q description binding site for Di-peptide 6O8 B 801 and ARG B 491 source : AE5 106) chain B residue 495 type sequence Y description binding site for Di-peptide 6O8 B 801 and ARG B 491 source : AE5 107) chain B residue 513 type sequence E description binding site for Di-peptide 6O8 B 801 and ARG B 491 source : AE5 108) chain B residue 516 type sequence F description binding site for Di-peptide 6O8 B 801 and ARG B 491 source : AE5 109) chain B residue 554 type sequence Y description binding site for Di-peptide 6O8 B 801 and ARG B 491 source : AE5 110) chain B residue 555 type sequence Y description binding site for Di-peptide 6O8 B 801 and ARG B 491 source : AE5 111) chain B residue 437 type sequence N description binding site for Di-peptide 6O8 B 801 and PHE B 516 source : AE6 112) chain B residue 440 type sequence V description binding site for Di-peptide 6O8 B 801 and PHE B 516 source : AE6 113) chain B residue 488 type sequence F description binding site for Di-peptide 6O8 B 801 and PHE B 516 source : AE6 114) chain B residue 491 type sequence R description binding site for Di-peptide 6O8 B 801 and PHE B 516 source : AE6 115) chain B residue 512 type sequence S description binding site for Di-peptide 6O8 B 801 and PHE B 516 source : AE6 116) chain B residue 513 type sequence E description binding site for Di-peptide 6O8 B 801 and PHE B 516 source : AE6 117) chain B residue 514 type sequence I description binding site for Di-peptide 6O8 B 801 and PHE B 516 source : AE6 118) chain B residue 515 type sequence L description binding site for Di-peptide 6O8 B 801 and PHE B 516 source : AE6 119) chain B residue 517 type sequence F description binding site for Di-peptide 6O8 B 801 and PHE B 516 source : AE6 120) chain B residue 518 type sequence V description binding site for Di-peptide 6O8 B 801 and PHE B 516 source : AE6 121) chain B residue 520 type sequence S description binding site for Di-peptide 6O8 B 801 and PHE B 516 source : AE6 122) chain B residue 551 type sequence N description binding site for Di-peptide 6O8 B 801 and PHE B 516 source : AE6 123) chain B residue 554 type sequence Y description binding site for Di-peptide 6O8 B 801 and PHE B 516 source : AE6 124) chain B residue 555 type sequence Y description binding site for Di-peptide 6O8 B 801 and PHE B 516 source : AE6 125) chain C residue 437 type sequence N description binding site for Di-peptide 6O8 C 801 and PHE C 516 source : AE7 126) chain C residue 440 type sequence V description binding site for Di-peptide 6O8 C 801 and PHE C 516 source : AE7 127) chain C residue 488 type sequence F description binding site for Di-peptide 6O8 C 801 and PHE C 516 source : AE7 128) chain C residue 491 type sequence R description binding site for Di-peptide 6O8 C 801 and PHE C 516 source : AE7 129) chain C residue 512 type sequence S description binding site for Di-peptide 6O8 C 801 and PHE C 516 source : AE7 130) chain C residue 513 type sequence E description binding site for Di-peptide 6O8 C 801 and PHE C 516 source : AE7 131) chain C residue 514 type sequence I description binding site for Di-peptide 6O8 C 801 and PHE C 516 source : AE7 132) chain C residue 515 type sequence L description binding site for Di-peptide 6O8 C 801 and PHE C 516 source : AE7 133) chain C residue 517 type sequence F description binding site for Di-peptide 6O8 C 801 and PHE C 516 source : AE7 134) chain C residue 518 type sequence V description binding site for Di-peptide 6O8 C 801 and PHE C 516 source : AE7 135) chain C residue 520 type sequence S description binding site for Di-peptide 6O8 C 801 and PHE C 516 source : AE7 136) chain C residue 551 type sequence N description binding site for Di-peptide 6O8 C 801 and PHE C 516 source : AE7 137) chain C residue 554 type sequence Y description binding site for Di-peptide 6O8 C 801 and PHE C 516 source : AE7 138) chain C residue 555 type sequence Y description binding site for Di-peptide 6O8 C 801 and PHE C 516 source : AE7 139) chain C residue 437 type sequence N description binding site for Di-peptide 6O8 C 801 and ARG C 491 source : AE8 140) chain C residue 440 type sequence V description binding site for Di-peptide 6O8 C 801 and ARG C 491 source : AE8 141) chain C residue 487 type sequence Y description binding site for Di-peptide 6O8 C 801 and ARG C 491 source : AE8 142) chain C residue 488 type sequence F description binding site for Di-peptide 6O8 C 801 and ARG C 491 source : AE8 143) chain C residue 489 type sequence F description binding site for Di-peptide 6O8 C 801 and ARG C 491 source : AE8 144) chain C residue 490 type sequence F description binding site for Di-peptide 6O8 C 801 and ARG C 491 source : AE8 145) chain C residue 492 type sequence G description binding site for Di-peptide 6O8 C 801 and ARG C 491 source : AE8 146) chain C residue 493 type sequence I description binding site for Di-peptide 6O8 C 801 and ARG C 491 source : AE8 147) chain C residue 494 type sequence Q description binding site for Di-peptide 6O8 C 801 and ARG C 491 source : AE8 148) chain C residue 495 type sequence Y description binding site for Di-peptide 6O8 C 801 and ARG C 491 source : AE8 149) chain C residue 513 type sequence E description binding site for Di-peptide 6O8 C 801 and ARG C 491 source : AE8 150) chain C residue 516 type sequence F description binding site for Di-peptide 6O8 C 801 and ARG C 491 source : AE8 151) chain C residue 554 type sequence Y description binding site for Di-peptide 6O8 C 801 and ARG C 491 source : AE8 152) chain C residue 555 type sequence Y description binding site for Di-peptide 6O8 C 801 and ARG C 491 source : AE8 153) chain D residue 370 type MOD_RES sequence T description Phosphothreonine; by PKA; in vitro => ECO:0000269|PubMed:12194871 source Swiss-Prot : SWS_FT_FI10 154) chain E residue 370 type MOD_RES sequence T description Phosphothreonine; by PKA; in vitro => ECO:0000269|PubMed:12194871 source Swiss-Prot : SWS_FT_FI10 155) chain B residue 370 type MOD_RES sequence T description Phosphothreonine; by PKA; in vitro => ECO:0000269|PubMed:12194871 source Swiss-Prot : SWS_FT_FI10 156) chain C residue 370 type MOD_RES sequence T description Phosphothreonine; by PKA; in vitro => ECO:0000269|PubMed:12194871 source Swiss-Prot : SWS_FT_FI10 157) chain D residue 502 type MOD_RES sequence S description Phosphoserine; by PKC/PRKCE => ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:12194871, ECO:0000269|PubMed:14630912 source Swiss-Prot : SWS_FT_FI11 158) chain E residue 502 type MOD_RES sequence S description Phosphoserine; by PKC/PRKCE => ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:12194871, ECO:0000269|PubMed:14630912 source Swiss-Prot : SWS_FT_FI11 159) chain B residue 502 type MOD_RES sequence S description Phosphoserine; by PKC/PRKCE => ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:12194871, ECO:0000269|PubMed:14630912 source Swiss-Prot : SWS_FT_FI11 160) chain C residue 502 type MOD_RES sequence S description Phosphoserine; by PKC/PRKCE => ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:12194871, ECO:0000269|PubMed:14630912 source Swiss-Prot : SWS_FT_FI11 161) chain D residue 433-453 type TRANSMEM sequence IFYFNFFVYCLYMIIFTAAAY description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 162) chain E residue 536-556 type TRANSMEM sequence EYVASMVFSLAMGWTNMLYYT description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 163) chain E residue 572-599 type TRANSMEM sequence MILRDLCRFMFVYLVFLFGFSTAVVTLI description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 164) chain E residue 681-709 type TRANSMEM sequence LMGETVNKIAQESKNIWKLQRAITILDTE description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 165) chain B residue 433-453 type TRANSMEM sequence IFYFNFFVYCLYMIIFTAAAY description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 166) chain B residue 472-497 type TRANSMEM sequence YFRVTGEILSVSGGVYFFFRGIQYFL description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 167) chain B residue 511-531 type TRANSMEM sequence YSEILFFVQSLFMLVSVVLYF description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 168) chain B residue 536-556 type TRANSMEM sequence EYVASMVFSLAMGWTNMLYYT description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 169) chain B residue 572-599 type TRANSMEM sequence MILRDLCRFMFVYLVFLFGFSTAVVTLI description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 170) chain B residue 658-686 type TRANSMEM sequence VFIILLLAYVILTYILLLNMLIALMGETV description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 171) chain C residue 433-453 type TRANSMEM sequence IFYFNFFVYCLYMIIFTAAAY description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 172) chain D residue 472-497 type TRANSMEM sequence YFRVTGEILSVSGGVYFFFRGIQYFL description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 173) chain C residue 472-497 type TRANSMEM sequence YFRVTGEILSVSGGVYFFFRGIQYFL description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 174) chain C residue 511-531 type TRANSMEM sequence YSEILFFVQSLFMLVSVVLYF description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 175) chain C residue 536-556 type TRANSMEM sequence EYVASMVFSLAMGWTNMLYYT description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 176) chain C residue 572-599 type TRANSMEM sequence MILRDLCRFMFVYLVFLFGFSTAVVTLI description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 177) chain C residue 658-686 type TRANSMEM sequence VFIILLLAYVILTYILLLNMLIALMGETV description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 178) chain D residue 511-531 type TRANSMEM sequence YSEILFFVQSLFMLVSVVLYF description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 179) chain D residue 536-556 type TRANSMEM sequence EYVASMVFSLAMGWTNMLYYT description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 180) chain D residue 572-599 type TRANSMEM sequence MILRDLCRFMFVYLVFLFGFSTAVVTLI description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 181) chain D residue 658-686 type TRANSMEM sequence VFIILLLAYVILTYILLLNMLIALMGETV description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 182) chain E residue 433-453 type TRANSMEM sequence IFYFNFFVYCLYMIIFTAAAY description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 183) chain E residue 472-497 type TRANSMEM sequence YFRVTGEILSVSGGVYFFFRGIQYFL description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 184) chain E residue 511-531 type TRANSMEM sequence YSEILFFVQSLFMLVSVVLYF description Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 185) chain D residue 627 type CARBOHYD sequence Y description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11683872 source Swiss-Prot : SWS_FT_FI13 186) chain E residue 627 type CARBOHYD sequence Y description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11683872 source Swiss-Prot : SWS_FT_FI13 187) chain B residue 627 type CARBOHYD sequence Y description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11683872 source Swiss-Prot : SWS_FT_FI13 188) chain C residue 627 type CARBOHYD sequence Y description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11683872 source Swiss-Prot : SWS_FT_FI13 189) chain D residue 454-471 type TOPO_DOM sequence YRPVEGLPPYKLKNTVGD description Extracellular => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI2 190) chain C residue 454-471 type TOPO_DOM sequence YRPVEGLPPYKLKNTVGD description Extracellular => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI2 191) chain C residue 532-535 type TOPO_DOM sequence SQRK description Extracellular => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI2 192) chain C residue 600-649 type TOPO_DOM sequence EDGKYNSLYSTCLELFKFTIGMGDLEF description Extracellular => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI2 193) chain D residue 532-535 type TOPO_DOM sequence SQRK description Extracellular => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI2 194) chain D residue 600-649 type TOPO_DOM sequence EDGKYNSLYSTCLELFKFTIGMGDLEF description Extracellular => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI2 195) chain E residue 454-471 type TOPO_DOM sequence YRPVEGLPPYKLKNTVGD description Extracellular => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI2 196) chain E residue 532-535 type TOPO_DOM sequence SQRK description Extracellular => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI2 197) chain E residue 600-649 type TOPO_DOM sequence EDGKYNSLYSTCLELFKFTIGMGDLEF description Extracellular => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI2 198) chain B residue 454-471 type TOPO_DOM sequence YRPVEGLPPYKLKNTVGD description Extracellular => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI2 199) chain B residue 532-535 type TOPO_DOM sequence SQRK description Extracellular => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI2 200) chain B residue 600-649 type TOPO_DOM sequence EDGKYNSLYSTCLELFKFTIGMGDLEF description Extracellular => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI2 201) chain D residue 498-510 type TOPO_DOM sequence QRRPSLKSLFVDS description Cytoplasmic => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI3 202) chain D residue 557-571 type TOPO_DOM sequence RGFQQMGIYAVMIEK description Cytoplasmic => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI3 203) chain E residue 498-510 type TOPO_DOM sequence QRRPSLKSLFVDS description Cytoplasmic => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI3 204) chain E residue 557-571 type TOPO_DOM sequence RGFQQMGIYAVMIEK description Cytoplasmic => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI3 205) chain B residue 498-510 type TOPO_DOM sequence QRRPSLKSLFVDS description Cytoplasmic => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI3 206) chain B residue 557-571 type TOPO_DOM sequence RGFQQMGIYAVMIEK description Cytoplasmic => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI3 207) chain C residue 498-510 type TOPO_DOM sequence QRRPSLKSLFVDS description Cytoplasmic => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI3 208) chain C residue 557-571 type TOPO_DOM sequence RGFQQMGIYAVMIEK description Cytoplasmic => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI3 209) chain D residue 627-649 type INTRAMEM sequence YNSLYSTCLELFKFTIGMGDLEF description Pore-forming => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200, ECO:0000305|PubMed:10931826 source Swiss-Prot : SWS_FT_FI4 210) chain E residue 650-672 type INTRAMEM sequence TENYDFKAVFIILLLAYVILTYI description Pore-forming => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200, ECO:0000305|PubMed:10931826 source Swiss-Prot : SWS_FT_FI4 211) chain B residue 627-649 type INTRAMEM sequence YNSLYSTCLELFKFTIGMGDLEF description Pore-forming => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200, ECO:0000305|PubMed:10931826 source Swiss-Prot : SWS_FT_FI4 212) chain C residue 627-649 type INTRAMEM sequence YNSLYSTCLELFKFTIGMGDLEF description Pore-forming => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200, ECO:0000305|PubMed:10931826 source Swiss-Prot : SWS_FT_FI4 213) chain D residue 704 type MOD_RES sequence T description Phosphothreonine => ECO:0000269|PubMed:14630912 source Swiss-Prot : SWS_FT_FI12 214) chain E residue 727 type MOD_RES sequence Q description Phosphothreonine => ECO:0000269|PubMed:14630912 source Swiss-Prot : SWS_FT_FI12 215) chain B residue 704 type MOD_RES sequence T description Phosphothreonine => ECO:0000269|PubMed:14630912 source Swiss-Prot : SWS_FT_FI12 216) chain C residue 704 type MOD_RES sequence T description Phosphothreonine => ECO:0000269|PubMed:14630912 source Swiss-Prot : SWS_FT_FI12 217) chain D residue 511 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX source Swiss-Prot : SWS_FT_FI7 218) chain C residue 511 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX source Swiss-Prot : SWS_FT_FI7 219) chain C residue 550 type BINDING sequence T description BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX source Swiss-Prot : SWS_FT_FI7 220) chain C residue 557 type BINDING sequence R description BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX source Swiss-Prot : SWS_FT_FI7 221) chain D residue 550 type BINDING sequence T description BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX source Swiss-Prot : SWS_FT_FI7 222) chain D residue 557 type BINDING sequence R description BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX source Swiss-Prot : SWS_FT_FI7 223) chain E residue 511 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX source Swiss-Prot : SWS_FT_FI7 224) chain E residue 550 type BINDING sequence T description BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX source Swiss-Prot : SWS_FT_FI7 225) chain E residue 557 type BINDING sequence R description BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX source Swiss-Prot : SWS_FT_FI7 226) chain B residue 511 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX source Swiss-Prot : SWS_FT_FI7 227) chain B residue 550 type BINDING sequence T description BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX source Swiss-Prot : SWS_FT_FI7 228) chain B residue 557 type BINDING sequence R description BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX source Swiss-Prot : SWS_FT_FI7 229) chain D residue 646 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:Q9R186 source Swiss-Prot : SWS_FT_FI8 230) chain E residue 669 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:Q9R186 source Swiss-Prot : SWS_FT_FI8 231) chain B residue 646 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:Q9R186 source Swiss-Prot : SWS_FT_FI8 232) chain C residue 646 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:Q9R186 source Swiss-Prot : SWS_FT_FI8

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