eF-site ID 5irx-E PDB Code 5irx Chain E click to enlarge Title Structure of TRPV1 in complex with DkTx and RTX, determined in lipid nanodisc Classification TRANSPORT PROTEIN Compound Transient receptor potential cation channel subfamily V member 1 Source (DKTX_HAPSC) Sequence E:  DCAKEGEVCSWGKKCCDLDNFYCPMEFIPHCKKYKPYVPV TTNCAKEGEVCGWGSKCCHGLDCPLAFIPYCEKYR Description (1)  Transient receptor potential cation channel subfamily V member 1, Tau-theraphotoxin-Hs1a Functional site 1) chain E residue 50 type sequence V description binding site for residue 6O9 D 802 source : AD3 2) chain E residue 53 type sequence W description binding site for residue 6O9 D 802 source : AD3 3) chain E residue 66 type sequence A description binding site for residue 6OE D 803 source : AD4 4) chain E residue 67 type sequence F description binding site for residue 6OE D 803 source : AD4 5) chain E residue 7 type sequence E description binding site for residue 6O9 E 101 source : AD7 6) chain E residue 8 type sequence V description binding site for residue 6O9 E 101 source : AD7 7) chain E residue 11 type sequence W description binding site for residue 6O9 E 101 source : AD7 8) chain E residue 26 type sequence E description binding site for residue 6OE E 102 source : AD8 9) chain E residue 25 type SITE sequence M description Important residue for activation of TRPV1 => ECO:0000305|PubMed:26880553 source Swiss-Prot : SWS_FT_FI2 10) chain E residue 67 type SITE sequence F description Interacts with TRPV1 (reaches into the void formed by S4, S6 and pore-helix) => ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 11) chain E residue 11 type SITE sequence W description Interacts with TRPV1 (reaches into the void formed by S4, S6 and pore-helix) => ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 12) chain E residue 27 type SITE sequence F description Interacts with TRPV1 (reaches into the void formed by S4, S6 and pore-helix) => ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 13) chain E residue 53 type SITE sequence W description Interacts with TRPV1 (reaches into the void formed by S4, S6 and pore-helix) => ECO:0000269|PubMed:27281200 source Swiss-Prot : SWS_FT_FI1 14) chain E residue 65 type SITE sequence L description Important residue for activation of TRPV1 => ECO:0000269|PubMed:26880553 source Swiss-Prot : SWS_FT_FI3

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