eF-site ID 5irx-A PDB Code 5irx Chain A click to enlarge Title Structure of TRPV1 in complex with DkTx and RTX, determined in lipid nanodisc Classification TRANSPORT PROTEIN Compound Transient receptor potential cation channel subfamily V member 1 Source (DKTX_HAPSC) Sequence A:  TPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAY GPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLL VEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYY RPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQ YFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQR KEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMIL RDLCRFMFVYLVFLFGFSTAVVTLIEDGKYNSLYSTCLEL FKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNM LIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMR KAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTT Description (1)  Transient receptor potential cation channel subfamily V member 1, Tau-theraphotoxin-Hs1a Functional site 1) chain A residue 437 type sequence N description binding site for residue 6O8 A 801 source : AC1 2) chain A residue 440 type sequence V description binding site for residue 6O8 A 801 source : AC1 3) chain A residue 487 type sequence Y description binding site for residue 6O8 A 801 source : AC1 4) chain A residue 488 type sequence F description binding site for residue 6O8 A 801 source : AC1 5) chain A residue 491 type sequence R description binding site for residue 6O8 A 801 source : AC1 6) chain A residue 513 type sequence E description binding site for residue 6O8 A 801 source : AC1 7) chain A residue 516 type sequence F description binding site for residue 6O8 A 801 source : AC1 8) chain A residue 554 type sequence Y description binding site for residue 6O8 A 801 source : AC1 9) chain A residue 555 type sequence Y description binding site for residue 6O8 A 801 source : AC1 10) chain A residue 629 type sequence S description binding site for residue 6OE A 802 source : AC2 11) chain A residue 631 type sequence Y description binding site for residue 6OE A 802 source : AC2 12) chain A residue 532 type sequence S description binding site for residue 6OE A 803 source : AC3 13) chain A residue 534 type sequence R description binding site for residue 6OE A 803 source : AC3 14) chain A residue 511 type sequence Y description binding site for residue 6EU A 804 source : AC4 15) chain A residue 512 type sequence S description binding site for residue 6EU A 804 source : AC4 16) chain A residue 514 type sequence I description binding site for residue 6EU A 804 source : AC4 17) chain A residue 515 type sequence L description binding site for residue 6EU A 804 source : AC4 18) chain A residue 546 type sequence A description binding site for residue 6EU A 804 source : AC4 19) chain A residue 547 type sequence M description binding site for residue 6EU A 804 source : AC4 20) chain A residue 550 type sequence T description binding site for residue 6EU A 804 source : AC4 21) chain A residue 551 type sequence N description binding site for residue 6EU A 804 source : AC4 22) chain A residue 553 type sequence L description binding site for residue 6EU A 804 source : AC4 23) chain A residue 554 type sequence Y description binding site for residue 6EU A 804 source : AC4 24) chain A residue 557 type sequence R description binding site for residue 6EU A 804 source : AC4 25) chain A residue 566 type sequence A description binding site for residue 6EU A 804 source : AC4 26) chain A residue 569 type sequence I description binding site for residue 6EU A 804 source : AC4 27) chain A residue 573 type sequence I description binding site for residue 6EU A 804 source : AC4 28) chain A residue 591 type sequence F description binding site for residue 6EU C 803 source : AD1 29) chain A residue 668 type sequence I description binding site for residue 6EU C 803 source : AD1 30) chain A residue 669 type sequence L description binding site for residue 6EU C 803 source : AD1 31) chain A residue 534 type sequence R description binding site for residue 6O9 F 102 source : AE1 32) chain A residue 453 type sequence Y description binding site for residue 6OE F 103 source : AE2 33) chain A residue 600-649 type SITE sequence EDGKYNSLYSTCLELFKFTIGMGDLEF description Important residue for activation of TRPV1 => ECO:0000305|PubMed:26880553 source Swiss-Prot : SWS_FT_FI2 34) chain A residue 650-672 type INTRAMEM sequence TENYDFKAVFIILLLAYVILTYI description Pore-forming => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200, ECO:0000305|PubMed:10931826 source Swiss-Prot : SWS_FT_FI4 35) chain A residue 370 type MOD_RES sequence T description Phosphothreonine; by PKA; in vitro => ECO:0000269|PubMed:12194871 source Swiss-Prot : SWS_FT_FI10 36) chain A residue 502 type MOD_RES sequence S description Phosphoserine; by PKC/PRKCE => ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:12194871, ECO:0000269|PubMed:14630912 source Swiss-Prot : SWS_FT_FI11 37) chain A residue 727 type MOD_RES sequence Q description Phosphothreonine => ECO:0000269|PubMed:14630912 source Swiss-Prot : SWS_FT_FI12 38) chain A residue 627 type CARBOHYD sequence Y description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11683872 source Swiss-Prot : SWS_FT_FI13 39) chain A residue 511 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX source Swiss-Prot : SWS_FT_FI7 40) chain A residue 550 type BINDING sequence T description BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX source Swiss-Prot : SWS_FT_FI7 41) chain A residue 557 type BINDING sequence R description BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX source Swiss-Prot : SWS_FT_FI7 42) chain A residue 669 type BINDING sequence L description BINDING => ECO:0000250|UniProtKB:Q9R186 source Swiss-Prot : SWS_FT_FI8

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