eF-site ID 5ijc-ABCD PDB Code 5ijc Chain A, B, C, D click to enlarge Title The crystal structure of mouse TLR4/MD-2/neoseptin-3 complex Classification IMMUNE SYSTEM Compound Toll-like receptor 4,Variable lymphocyte receptor B Source (LY96_MOUSE) Sequence A:  PCIEVVITYQCMDQKLSKVDDIPSSTKNIDLSFNPLKILK SYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILT GNPIQSFSPGSFSGLTSLENLVAVETKLASLESFPIGQLI TLKKLNVAHNFIHSCKLPAYFSNLTNLVHVDLSYNYIQTI TVNDLQFLRENPQVNLSLDMSLNPIDFIQDQAFQGIKLHE LTLRGNFNSSNIMKTCLQNLAGLHVHRLILGEFKDERNLE IFEPSIMEGLCDVTIDEFRLTYTNDFSDDIVKFHCLANVS AMSLAGVSIKYLEDVPKHFKWQSLSIIRCQLKQFPTLDLP FLKSLTLTMNKGSISFKKVALPSLSYLDLSRNALSFSGCC SYSDLGTNSLRHLDLSFNGAIIMSANFMGLEELQHLDFQH STLKRVTEFSAFLSLEKLLYLDISYTNTKIDFDGIFLGLT SLNTLKMAGNSFKDNTLSNVFANTTNLTFLDLSKCQLEQI SWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLKELAL DTNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPRIDYLS RWLNKNSQKEQGSAKCSGSGKPVRSIICP B:  PCIEVVPNITYQCMDQKLSKVPDDIPSSTKNIDLSFNPLK ILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNL ILTGNPIQSFSPGSFSGLTSLENLVAVETKLASLESFPIG QLITLKKLNVAHNFIHSCKLPAYFSNLTNLVHVDLSYNYI QTITVNDLQFLRENPQVNLSLDMSLNPIDFIQDQAFQGIK LHELTLRGNFNSSNIMKTCLQNLAGLHVHRLILGEFKDER NLEIFEPSIMEGLCDVTIDEFRLTYTNDFSDDIVKFHCLA NVSAMSLAGVSIKYLEDVPKHFKWQSLSIIRCQLKQFPTL DLPFLKSLTLTMNKGSISFKKVALPSLSYLDLSRNALSFS GCCSYSDLGTNSLRHLDLSFNGAIIMSANFMGLEELQHLD FQHSTLKRVTEFSAFLSLEKLLYLDISYTNTKIDFDGIFL GLTSLNTLKMAGNSFKDNTLSNVFANTTNLTFLDLSKCQL EQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLKE LALDTNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPRID YLSRWLNKNSQKEQGSAKCSGSGKPVRSIICPT C:  QQWFCNSSDAIISYSYCDHLKFPISISSEPCIRLRGTNGF VHVEFIPRGNLKYLYFNLFISVNSIELPKRKEVLCHGHDD DYSFCRALKGETVNTSIPFSFEGILFPKGHYRCVAEAIAG DTEEKLFCLNFTIIHR D:  QQWFCNSSDAIISYSYCDHLKFPISISSEPCIRLRGTNGF VHVEFIPRGNLKYLYFNLFISVNSIELPKRKEVLCHGHDD DYSFCRALKGETVNTSIPFSFEGILFPKGHYRCVAEAIAG DTEEKLFCLNFTIIHR Description Functional site 1) chain A residue 224-233 type prosite sequence GIKLHELTLR description ALDOLASE_KDPG_KHG_1 KDPG and KHG aldolases active site. GIklhELTLR source prosite : PS00159 2) chain C residue 114 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912 source Swiss-Prot : SWS_FT_FI2 3) chain C residue 150 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912 source Swiss-Prot : SWS_FT_FI2 4) chain D residue 114 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912 source Swiss-Prot : SWS_FT_FI2 5) chain D residue 150 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912 source Swiss-Prot : SWS_FT_FI2 6) chain C residue 26 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912, ECO:0007744|PDB:2Z64 source Swiss-Prot : SWS_FT_FI1 7) chain D residue 26 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912, ECO:0007744|PDB:2Z64 source Swiss-Prot : SWS_FT_FI1 8) chain A residue 172 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912, ECO:0007744|PDB:2Z64 source Swiss-Prot : SWS_FT_FI1 9) chain A residue 204 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912, ECO:0007744|PDB:2Z64 source Swiss-Prot : SWS_FT_FI1 10) chain A residue 237 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912, ECO:0007744|PDB:2Z64 source Swiss-Prot : SWS_FT_FI1 11) chain A residue 307 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912, ECO:0007744|PDB:2Z64 source Swiss-Prot : SWS_FT_FI1 12) chain A residue 492 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912, ECO:0007744|PDB:2Z64 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 524 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912, ECO:0007744|PDB:2Z64 source Swiss-Prot : SWS_FT_FI1 14) chain B residue 34 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912, ECO:0007744|PDB:2Z64 source Swiss-Prot : SWS_FT_FI1 15) chain B residue 75 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912, ECO:0007744|PDB:2Z64 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 172 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912, ECO:0007744|PDB:2Z64 source Swiss-Prot : SWS_FT_FI1 17) chain B residue 204 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912, ECO:0007744|PDB:2Z64 source Swiss-Prot : SWS_FT_FI1 18) chain B residue 237 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912, ECO:0007744|PDB:2Z64 source Swiss-Prot : SWS_FT_FI1 19) chain B residue 307 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912, ECO:0007744|PDB:2Z64 source Swiss-Prot : SWS_FT_FI1 20) chain B residue 492 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912, ECO:0007744|PDB:2Z64 source Swiss-Prot : SWS_FT_FI1 21) chain B residue 524 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912, ECO:0007744|PDB:2Z64 source Swiss-Prot : SWS_FT_FI1

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