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eF-site ID
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5ij8-T |
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PDB Code
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5ij8 |
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Chain
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T |
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click to enlarge
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Title
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Structure of the primary oncogenic mutant Y641N Hs/AcPRC2 in complex with a pyridone inhibitor |
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Classification
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transferase/transferase inhibitor |
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Compound
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Enhancer of Zeste Homolog 2 (EZH2),Histone-lysine N-methyltransferase EZH2 |
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Source
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null (SUZ12_HUMAN) |
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Sequence
|
T: |
HNRLYFHSDTCLPLRPQEMEVDDEDEKDPEWLREKTITQI
EEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFV
ENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTK
LREMQQKL
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Description
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Functional site
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|
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1)
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chain |
T |
| residue |
583 |
| type |
MOD_RES |
| sequence |
D
|
| description |
Phosphoserine => ECO:0007744|PubMed:18220336
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| source |
Swiss-Prot : SWS_FT_FI2
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