|
eF-site ID
|
5ij8-F |
PDB Code
|
5ij8 |
Chain
|
F |
|
click to enlarge
|
|
Title
|
Structure of the primary oncogenic mutant Y641N Hs/AcPRC2 in complex with a pyridone inhibitor |
Classification
|
transferase/transferase inhibitor |
Compound
|
Enhancer of Zeste Homolog 2 (EZH2),Histone-lysine N-methyltransferase EZH2 |
Source
|
null (SUZ12_HUMAN) |
|
Sequence
|
F: |
FKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRV
TLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHP
LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPR
DPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLS
ADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYN
PNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILS
KSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQC
DIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKC
TTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
F |
residue |
222 |
type |
|
sequence |
R
|
description |
binding site for residue 6BN A 9001
|
source |
: AC1
|
|
2)
|
chain |
F |
residue |
223 |
type |
|
sequence |
D
|
description |
binding site for residue 6BN A 9001
|
source |
: AC1
|
|
3)
|
chain |
F |
residue |
183 |
type |
MOD_RES |
sequence |
K
|
description |
Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
4)
|
chain |
F |
residue |
254 |
type |
MOD_RES |
sequence |
K
|
description |
Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
5)
|
chain |
F |
residue |
270 |
type |
MOD_RES |
sequence |
K
|
description |
Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|