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eF-site ID
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5ij8-F |
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PDB Code
|
5ij8 |
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Chain
|
F |
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click to enlarge
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Title
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Structure of the primary oncogenic mutant Y641N Hs/AcPRC2 in complex with a pyridone inhibitor |
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Classification
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transferase/transferase inhibitor |
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Compound
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Enhancer of Zeste Homolog 2 (EZH2),Histone-lysine N-methyltransferase EZH2 |
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Source
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Homo sapiens (Human) (SUZ12_HUMAN) |
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Sequence
|
F: |
FKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRV
TLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHP
LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPR
DPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLS
ADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYN
PNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILS
KSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQC
DIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKC
TTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL
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Description
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Functional site
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|
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1)
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chain |
F |
| residue |
222 |
| type |
|
| sequence |
R
|
| description |
binding site for residue 6BN A 9001
|
| source |
: AC1
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|
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2)
|
chain |
F |
| residue |
223 |
| type |
|
| sequence |
D
|
| description |
binding site for residue 6BN A 9001
|
| source |
: AC1
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|
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3)
|
chain |
F |
| residue |
183 |
| type |
MOD_RES |
| sequence |
K
|
| description |
Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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4)
|
chain |
F |
| residue |
254 |
| type |
MOD_RES |
| sequence |
K
|
| description |
Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
F |
| residue |
270 |
| type |
MOD_RES |
| sequence |
K
|
| description |
Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
|
| source |
Swiss-Prot : SWS_FT_FI1
|
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|
|