eF-site ID 5ij8-B PDB Code 5ij8 Chain B click to enlarge Title Structure of the primary oncogenic mutant Y641N Hs/AcPRC2 in complex with a pyridone inhibitor Classification transferase/transferase inhibitor Compound Enhancer of Zeste Homolog 2 (EZH2),Histone-lysine N-methyltransferase EZH2 Source Homo sapiens (Human) (SUZ12_HUMAN) Sequence B:  EKGPICWRKRVKSEYMRLRQLKRFRRADEVKSMFNSNRQK IQERTEILNQEWKQRRIQPVHIMTRECSVTSDLDFPKQVI PLKTLNAVASVPIMYSWSPLQQNFMVEDINDEIFVELVNA LGQLDRRDEKPSDKIFEAISSMFPDKGTAEELKEKYKELT CTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPF HATPNTYKRSGAEASMFRVLIGTYYDNFCAIARLIGTKTC RQVYEFRVKVYNYQPCDHPRQPCDNSCPCVIAQNFCEKFC QCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLT CGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIF IKDPVQKNEFISENCGEIISQDEADRRGKVYDKYMCSFLF NLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHR IGIFAKRAIQTGEELFFDYRYSQADA Description Functional site 1) chain B residue 109 type sequence I description binding site for residue 6BN B 9001 source : AC9 2) chain B residue 110 type sequence M description binding site for residue 6BN B 9001 source : AC9 3) chain B residue 111 type sequence Y description binding site for residue 6BN B 9001 source : AC9 4) chain B residue 623 type sequence G description binding site for residue 6BN B 9001 source : AC9 5) chain B residue 624 type sequence W description binding site for residue 6BN B 9001 source : AC9 6) chain B residue 661 type sequence Y description binding site for residue 6BN B 9001 source : AC9 7) chain B residue 663 type sequence C description binding site for residue 6BN B 9001 source : AC9 8) chain B residue 665 type sequence F description binding site for residue 6BN B 9001 source : AC9 9) chain B residue 685 type sequence R description binding site for residue 6BN B 9001 source : AC9 10) chain B residue 686 type sequence F description binding site for residue 6BN B 9001 source : AC9 11) chain B residue 687 type sequence A description binding site for residue 6BN B 9001 source : AC9 12) chain B residue 688 type sequence N description binding site for residue 6BN B 9001 source : AC9 13) chain B residue 530 type sequence C description binding site for residue ZN B 9002 source : AD1 14) chain B residue 543 type sequence C description binding site for residue ZN B 9002 source : AD1 15) chain B residue 549 type sequence C description binding site for residue ZN B 9002 source : AD1 16) chain B residue 553 type sequence C description binding site for residue ZN B 9002 source : AD1 17) chain B residue 523 type sequence C description binding site for residue ZN B 9003 source : AD2 18) chain B residue 536 type sequence C description binding site for residue ZN B 9003 source : AD2 19) chain B residue 543 type sequence C description binding site for residue ZN B 9003 source : AD2 20) chain B residue 547 type sequence C description binding site for residue ZN B 9003 source : AD2 21) chain B residue 523 type sequence C description binding site for residue ZN B 9004 source : AD3 22) chain B residue 525 type sequence H description binding site for residue ZN B 9004 source : AD3 23) chain B residue 530 type sequence C description binding site for residue ZN B 9004 source : AD3 24) chain B residue 534 type sequence C description binding site for residue ZN B 9004 source : AD3 25) chain B residue 560 type sequence C description binding site for residue ZN B 9005 source : AD4 26) chain B residue 573 type sequence C description binding site for residue ZN B 9005 source : AD4 27) chain B residue 580 type sequence C description binding site for residue ZN B 9005 source : AD4 28) chain B residue 585 type sequence C description binding site for residue ZN B 9005 source : AD4 29) chain B residue 566 type sequence C description binding site for residue ZN B 9006 source : AD5 30) chain B residue 580 type sequence C description binding site for residue ZN B 9006 source : AD5 31) chain B residue 588 type sequence C description binding site for residue ZN B 9006 source : AD5 32) chain B residue 601 type sequence C description binding site for residue ZN B 9006 source : AD5 33) chain B residue 560 type sequence C description binding site for residue ZN B 9007 source : AD6 34) chain B residue 562 type sequence C description binding site for residue ZN B 9007 source : AD6 35) chain B residue 566 type sequence C description binding site for residue ZN B 9007 source : AD6 36) chain B residue 571 type sequence C description binding site for residue ZN B 9007 source : AD6 37) chain B residue 286 type sequence C description binding site for residue ZN B 9008 source : AD7 38) chain B residue 289 type sequence C description binding site for residue ZN B 9008 source : AD7 39) chain B residue 294 type sequence C description binding site for residue ZN B 9008 source : AD7 40) chain B residue 297 type sequence H description binding site for residue ZN B 9008 source : AD7 41) chain B residue 677 type MOD_RES sequence A description Phosphoserine => ECO:0007744|PubMed:18220336 source Swiss-Prot : SWS_FT_FI2

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