eF-site ID 5ij8-A PDB Code 5ij8 Chain A click to enlarge Title Structure of the primary oncogenic mutant Y641N Hs/AcPRC2 in complex with a pyridone inhibitor Classification transferase/transferase inhibitor Compound Enhancer of Zeste Homolog 2 (EZH2),Histone-lysine N-methyltransferase EZH2 Source Homo sapiens (Human) (SUZ12_HUMAN) Sequence A:  EKGPICWRKRVKSEYMRLRQLKRFRRADEVKSMFNSNRQK IQERTEILNQEWKQRRIQPVHIMRECSVTSDLDFPKQVIP LKTLNAVASVPIMYSWSPLQQNFMVEDINDEIFVELVNAL GQLDRRDEKPSDKIFEAISSMFPDKGTAEELKEKYKECTP NIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHAT PNTYKRWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQ VYEFRVKVYNYQPCDHPRQPCDNSCPCVIAQNFCEKFCQC SSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCG AADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIK DPVQKNEFISENCGEIISQDEADRRGKVYDKYMCSFLFNL NNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIG IFAKRAIQTGEELFFDYRYSQADA Description Functional site 1) chain A residue 109 type sequence I description binding site for residue 6BN A 9001 source : AC1 2) chain A residue 110 type sequence M description binding site for residue 6BN A 9001 source : AC1 3) chain A residue 111 type sequence Y description binding site for residue 6BN A 9001 source : AC1 4) chain A residue 623 type sequence G description binding site for residue 6BN A 9001 source : AC1 5) chain A residue 624 type sequence W description binding site for residue 6BN A 9001 source : AC1 6) chain A residue 661 type sequence Y description binding site for residue 6BN A 9001 source : AC1 7) chain A residue 663 type sequence C description binding site for residue 6BN A 9001 source : AC1 8) chain A residue 665 type sequence F description binding site for residue 6BN A 9001 source : AC1 9) chain A residue 685 type sequence R description binding site for residue 6BN A 9001 source : AC1 10) chain A residue 686 type sequence F description binding site for residue 6BN A 9001 source : AC1 11) chain A residue 687 type sequence A description binding site for residue 6BN A 9001 source : AC1 12) chain A residue 688 type sequence N description binding site for residue 6BN A 9001 source : AC1 13) chain A residue 523 type sequence C description binding site for residue ZN A 9002 source : AC2 14) chain A residue 525 type sequence H description binding site for residue ZN A 9002 source : AC2 15) chain A residue 530 type sequence C description binding site for residue ZN A 9002 source : AC2 16) chain A residue 534 type sequence C description binding site for residue ZN A 9002 source : AC2 17) chain A residue 523 type sequence C description binding site for residue ZN A 9003 source : AC3 18) chain A residue 536 type sequence C description binding site for residue ZN A 9003 source : AC3 19) chain A residue 543 type sequence C description binding site for residue ZN A 9003 source : AC3 20) chain A residue 547 type sequence C description binding site for residue ZN A 9003 source : AC3 21) chain A residue 530 type sequence C description binding site for residue ZN A 9004 source : AC4 22) chain A residue 543 type sequence C description binding site for residue ZN A 9004 source : AC4 23) chain A residue 549 type sequence C description binding site for residue ZN A 9004 source : AC4 24) chain A residue 553 type sequence C description binding site for residue ZN A 9004 source : AC4 25) chain A residue 564 type sequence A description binding site for residue ZN A 9005 source : AC5 26) chain A residue 565 type sequence Q description binding site for residue ZN A 9005 source : AC5 27) chain A residue 566 type sequence C description binding site for residue ZN A 9005 source : AC5 28) chain A residue 588 type sequence C description binding site for residue ZN A 9005 source : AC5 29) chain A residue 566 type sequence C description binding site for residue ZN A 9006 source : AC6 30) chain A residue 580 type sequence C description binding site for residue ZN A 9006 source : AC6 31) chain A residue 588 type sequence C description binding site for residue ZN A 9006 source : AC6 32) chain A residue 601 type sequence C description binding site for residue ZN A 9006 source : AC6 33) chain A residue 560 type sequence C description binding site for residue ZN A 9007 source : AC7 34) chain A residue 573 type sequence C description binding site for residue ZN A 9007 source : AC7 35) chain A residue 580 type sequence C description binding site for residue ZN A 9007 source : AC7 36) chain A residue 585 type sequence C description binding site for residue ZN A 9007 source : AC7 37) chain A residue 286 type sequence C description binding site for residue ZN A 9008 source : AC8 38) chain A residue 289 type sequence C description binding site for residue ZN A 9008 source : AC8 39) chain A residue 294 type sequence C description binding site for residue ZN A 9008 source : AC8 40) chain A residue 297 type sequence H description binding site for residue ZN A 9008 source : AC8

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