eF-site ID 5if0-ABGHIL PDB Code 5if0 Chain A, B, G, H, I, L click to enlarge Title Crystal structure of VRC01c-HuGL2 Fab from an HIV-1 naive donor in complex with with a germline-targeting gp120 engineered outer domain eOD-GT8 at 2.44 A Classification IMMUNE SYSTEM/VIRAL PROTEIN Compound VRC01cHuGL2 Fab heavy chain Source (5IF0) Sequence A:  QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYMHWVRQA PGQGLEWMGWINPNSGGTNYAQKFQGRVTMTRDTSISTAY MELSRLRSDDTAVYYCAKISGSYSFDYWGQGTLVTVSSAS TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWN SGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYI CNVNHKPSNTKVDKKVEPK B:  DIVMTQSPDSLAVSLGERATINCKSSQKNYLAWYQQKPGQ PPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAED VAVYYCQQYYSFGGGTKVEIKRTVAAPSVFIFPPSDEQLK SGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQ DSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLRSPVT KSFNRG G:  DTITLPCRPAPPPHCSSNITGLILTRQGGYSNANTVIFRP SGGDWRDIARCQIAGTVVSTQLFLNGSLAEEEVVIRSEDW RDNAKSICVQLATSVEIACTGAGHCAISRAKWANTLKQIA SKLREQYGAKTIIFKPSSGGDPEFVNHSFNCGGEFFYCAS TQLFASTWF H:  QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYMHWVRQA PGQGLEWMGWINPNSGGTNYAQKFQGRVTMTRDTSISTAY MELSRLRSDDTAVYYCAKISGSYSFDYWGQGTLVTVSSAS TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWN SGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYI CNVNHKPSNTKVDKKVEPK I:  DTITLPCRPAPPPHCSSNITGLILTRQGGYSNANTVIFRP SGGDWRDIARCQIAGTVVSTQLFLNGSLAEEEVVIRSEDW RDNAKSICVQLATSVEIACTGAGHCAISRAKWANTLKQIA SKLREQYGAKTIIFKPSSGGDPEFVNHSFNCGGEFFYCAS TQLFASTWF L:  DIVMTQSPDSLAVSLGERATINCKSSQKNYLAWYQQKPGQ PPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAED VAVYYCQQYYSFGGGTKVEIKRTVAAPSVFIFPPSDEQLK SGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQ DSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLRSPVT KSFNRG Description Functional site 1) chain B residue 192-198 type prosite sequence YACEVTH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH source prosite : PS00290 2) chain A residue 194-200 type prosite sequence YICNVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH source prosite : PS00290

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