eF-site ID 5idp-B PDB Code 5idp Chain B click to enlarge Title CDK8-CYCC IN COMPLEX WITH (3-Amino-1H-indazol-5-yl)-[(S)-2-(4-fluoro-phenyl)-piperidin-1-yl]-methanone Classification TRANSFERASE Compound Cyclin-dependent kinase 8 Source Homo sapiens (Human) (CCNC_HUMAN) Sequence B:  DDKAMAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEE YWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARY SLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVL KTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPY RPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFM IALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILK LYEQWKNFDERKEMATILSKMPKPKPPP Description Functional site 1) chain B residue 147 type sequence D description binding site for residue FMT A 403 source : AC3 2) chain B residue 41 type sequence Q description binding site for residue FMT B 301 source : AC4 3) chain B residue 45 type sequence T description binding site for residue FMT B 301 source : AC4 4) chain B residue 66 type sequence T description binding site for residue FMT B 301 source : AC4 5) chain B residue 69 type sequence F description binding site for residue FMT B 301 source : AC4 6) chain B residue 70 type sequence K description binding site for residue FMT B 301 source : AC4 7) chain B residue 49 type sequence Q description binding site for residue FMT B 302 source : AC5 8) chain B residue 59 type sequence Q description binding site for residue FMT B 302 source : AC5 9) chain B residue 63 type sequence A description binding site for residue FMT B 302 source : AC5 10) chain B residue 156 type sequence Y description binding site for residue FMT B 302 source : AC5 11) chain B residue -2 type sequence D description binding site for residue FMT B 303 source : AC6 12) chain B residue 0 type sequence A description binding site for residue FMT B 303 source : AC6 13) chain B residue 2 type sequence A description binding site for residue FMT B 303 source : AC6 14) chain B residue 153 type sequence Y description binding site for residue FMT B 303 source : AC6

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