eF-site ID 5idp-AB PDB Code 5idp Chain A, B click to enlarge Title CDK8-CYCC IN COMPLEX WITH (3-Amino-1H-indazol-5-yl)-[(S)-2-(4-fluoro-phenyl)-piperidin-1-yl]-methanone Classification TRANSFERASE Compound Cyclin-dependent kinase 8 Source null (CCNC_HUMAN) Sequence A:  KMDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAK RKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVI SLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKVQLP RGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGP ERGRVKIADMGFARLFNSPLKTFWYRAPELLLGARHYTKA IDIWAIGCIFAELLTSEPIFHCRQETSNPYHHDQLDRIFN VMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYM EKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLE DPLPTSDVFAGCQIPYPKREFL B:  DDKAMAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEE YWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARY SLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVL KTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPY RPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFM IALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILK LYEQWKNFDERKEMATILSKMPKPKPPP Description Functional site 1) chain A residue 27 type sequence V description binding site for residue 6A6 A 401 source : AC1 2) chain A residue 32 type sequence Y description binding site for residue 6A6 A 401 source : AC1 3) chain A residue 35 type sequence V description binding site for residue 6A6 A 401 source : AC1 4) chain A residue 50 type sequence A description binding site for residue 6A6 A 401 source : AC1 5) chain A residue 98 type sequence D description binding site for residue 6A6 A 401 source : AC1 6) chain A residue 99 type sequence Y description binding site for residue 6A6 A 401 source : AC1 7) chain A residue 100 type sequence A description binding site for residue 6A6 A 401 source : AC1 8) chain A residue 103 type sequence D description binding site for residue 6A6 A 401 source : AC1 9) chain A residue 155 type sequence A description binding site for residue 6A6 A 401 source : AC1 10) chain A residue 173 type sequence D description binding site for residue 6A6 A 401 source : AC1 11) chain A residue 356 type sequence R description binding site for residue 6A6 A 401 source : AC1 12) chain A residue 66 type sequence E description binding site for residue FMT A 402 source : AC2 13) chain A residue 173 type sequence D description binding site for residue FMT A 402 source : AC2 14) chain A residue 83 type sequence K description binding site for residue FMT A 403 source : AC3 15) chain A residue 84 type sequence V description binding site for residue FMT A 403 source : AC3 16) chain B residue 147 type sequence D description binding site for residue FMT A 403 source : AC3 17) chain B residue 41 type sequence Q description binding site for residue FMT B 301 source : AC4 18) chain B residue 45 type sequence T description binding site for residue FMT B 301 source : AC4 19) chain B residue 66 type sequence T description binding site for residue FMT B 301 source : AC4 20) chain B residue 69 type sequence F description binding site for residue FMT B 301 source : AC4 21) chain B residue 70 type sequence K description binding site for residue FMT B 301 source : AC4 22) chain B residue 49 type sequence Q description binding site for residue FMT B 302 source : AC5 23) chain B residue 59 type sequence Q description binding site for residue FMT B 302 source : AC5 24) chain B residue 63 type sequence A description binding site for residue FMT B 302 source : AC5 25) chain B residue 156 type sequence Y description binding site for residue FMT B 302 source : AC5 26) chain B residue -2 type sequence D description binding site for residue FMT B 303 source : AC6 27) chain B residue 0 type sequence A description binding site for residue FMT B 303 source : AC6 28) chain B residue 2 type sequence A description binding site for residue FMT B 303 source : AC6 29) chain B residue 153 type sequence Y description binding site for residue FMT B 303 source : AC6 30) chain A residue 27-52 type prosite sequence VGRGTYGHVYKAKRKDGKDDKDYALK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGTYGHVYkAkrkdgkddkd........YALK source prosite : PS00107 31) chain A residue 147-159 type prosite sequence VLHRDLKPANILV description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpaNILV source prosite : PS00108 32) chain A residue 151 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 33) chain A residue 52 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 34) chain A residue 27 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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