eF-site ID 5idn-B PDB Code 5idn Chain B click to enlarge Title CDK8-CYCC IN COMPLEX WITH [(S)-2-(4-Chloro-phenyl)-pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-methanone Classification TRANSFERASE Compound Cyclin-dependent kinase 8 Source Homo sapiens (Human) (CCNC_HUMAN) Sequence B:  DKAMAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEY WKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYS LKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLK TRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYR PLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMI ALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKL YEQWKNFDERKEMATILSKMPKPKPPP Description Functional site 1) chain B residue 2 type sequence A description binding site for residue FMT B 301 source : AC6 2) chain B residue 3 type sequence G description binding site for residue FMT B 301 source : AC6 3) chain B residue 153 type sequence Y description binding site for residue FMT B 301 source : AC6 4) chain B residue 157 type sequence R description binding site for residue FMT B 301 source : AC6 5) chain B residue 0 type sequence A description binding site for residue FMT B 302 source : AC7 6) chain B residue 153 type sequence Y description binding site for residue FMT B 302 source : AC7 7) chain B residue 203 type sequence H description binding site for residue FMT B 303 source : AC8 8) chain B residue 211 type sequence K description binding site for residue FMT B 303 source : AC8 9) chain B residue 212 type sequence D description binding site for residue FMT B 303 source : AC8 10) chain B residue 213 type sequence A description binding site for residue FMT B 303 source : AC8 11) chain B residue 214 type sequence R description binding site for residue FMT B 303 source : AC8

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