eF-site ID 5idn-A PDB Code 5idn Chain A click to enlarge Title CDK8-CYCC IN COMPLEX WITH [(S)-2-(4-Chloro-phenyl)-pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-methanone Classification TRANSFERASE Compound Cyclin-dependent kinase 8 Source Homo sapiens (Human) (CCNC_HUMAN) Sequence A:  MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKR KDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVIS LQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANLPR GMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPE RGRVKIADMGFARVTFWYRAPELLLGARHYTKAIDIWAIG CIFAELLTSEPIFHCRQNPYHHDQLDRIFNVMGFPADKDW EDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSK AFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFA GCQIPYPKREFLTEEE Description Functional site 1) chain A residue 27 type sequence V description binding site for residue 6A7 A 401 source : AC1 2) chain A residue 28 type sequence G description binding site for residue 6A7 A 401 source : AC1 3) chain A residue 32 type sequence Y description binding site for residue 6A7 A 401 source : AC1 4) chain A residue 50 type sequence A description binding site for residue 6A7 A 401 source : AC1 5) chain A residue 52 type sequence K description binding site for residue 6A7 A 401 source : AC1 6) chain A residue 79 type sequence I description binding site for residue 6A7 A 401 source : AC1 7) chain A residue 97 type sequence F description binding site for residue 6A7 A 401 source : AC1 8) chain A residue 98 type sequence D description binding site for residue 6A7 A 401 source : AC1 9) chain A residue 99 type sequence Y description binding site for residue 6A7 A 401 source : AC1 10) chain A residue 100 type sequence A description binding site for residue 6A7 A 401 source : AC1 11) chain A residue 155 type sequence A description binding site for residue 6A7 A 401 source : AC1 12) chain A residue 158 type sequence L description binding site for residue 6A7 A 401 source : AC1 13) chain A residue 173 type sequence D description binding site for residue 6A7 A 401 source : AC1 14) chain A residue 356 type sequence R description binding site for residue 6A7 A 401 source : AC1 15) chain A residue 125 type sequence R description binding site for residue EDO A 402 source : AC2 16) chain A residue 302 type sequence V description binding site for residue EDO A 402 source : AC2 17) chain A residue 303 type sequence K description binding site for residue EDO A 402 source : AC2 18) chain A residue 149 type sequence H description binding site for residue FMT A 403 source : AC3 19) chain A residue 151 type sequence D description binding site for residue FMT A 403 source : AC3 20) chain A residue 173 type sequence D description binding site for residue FMT A 403 source : AC3 21) chain A residue 176 type sequence F description binding site for residue FMT A 403 source : AC3 22) chain A residue 32 type sequence Y description binding site for residue FMT A 404 source : AC4 23) chain A residue 52 type sequence K description binding site for residue FMT A 404 source : AC4 24) chain A residue 62 type sequence S description binding site for residue FMT A 404 source : AC4 25) chain A residue 63 type sequence A description binding site for residue FMT A 404 source : AC4 26) chain A residue 17 type sequence E description binding site for residue FMT A 405 source : AC5 27) chain A residue 22 type sequence Y description binding site for residue FMT A 405 source : AC5 28) chain A residue 87 type sequence S description binding site for residue FMT A 405 source : AC5 29) chain A residue 90 type sequence D description binding site for residue FMT A 405 source : AC5 30) chain A residue 94 type sequence W description binding site for residue FMT A 405 source : AC5 31) chain A residue 151 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 32) chain A residue 27 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 33) chain A residue 52 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 34) chain A residue 27-52 type prosite sequence VGRGTYGHVYKAKRKDGKDDKDYALK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGTYGHVYkAkrkdgkddkd........YALK source prosite : PS00107 35) chain A residue 147-159 type prosite sequence VLHRDLKPANILV description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpaNILV source prosite : PS00108

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