eF-site ID 5icp-B PDB Code 5icp Chain B click to enlarge Title CDK8-CYCC IN COMPLEX WITH [(S)-2-(4-Chloro-phenyl)-pyrrolidin-1-yl]-(5-methyl-imidazo[5,1-b][1,3,4]thiadiazol-2-yl)-methanone Classification TRANSFERASE Compound Cyclin-dependent kinase 8 Source Homo sapiens (Human) (CCNC_HUMAN) Sequence B:  DKAMAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEY WKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYS LKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLK TRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYR PLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMI ALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKL YEQWKNFDERKEMATILSKMPKPKPPP Description Functional site 1) chain B residue 147 type sequence D description binding site for residue EDO A 403 source : AC3 2) chain B residue 7 type sequence Q description binding site for residue FMT A 405 source : AC5 3) chain B residue 9 type sequence S description binding site for residue FMT A 405 source : AC5 4) chain B residue 0 type sequence A description binding site for residue FMT B 301 source : AC8 5) chain B residue 2 type sequence A description binding site for residue FMT B 301 source : AC8 6) chain B residue 157 type sequence R description binding site for residue FMT B 301 source : AC8 7) chain B residue 41 type sequence Q description binding site for residue FMT B 302 source : AC9 8) chain B residue 41 type sequence Q description binding site for residue FMT B 303 source : AD1 9) chain B residue 45 type sequence T description binding site for residue FMT B 303 source : AD1 10) chain B residue 66 type sequence T description binding site for residue FMT B 303 source : AD1 11) chain B residue 69 type sequence F description binding site for residue FMT B 303 source : AD1 12) chain B residue 70 type sequence K description binding site for residue FMT B 303 source : AD1 13) chain B residue 203 type sequence H description binding site for residue FMT B 304 source : AD2 14) chain B residue 211 type sequence K description binding site for residue FMT B 304 source : AD2 15) chain B residue 213 type sequence A description binding site for residue FMT B 304 source : AD2 16) chain B residue 5 type sequence F description binding site for residue FMT B 305 source : AD3 17) chain B residue 194 type sequence P description binding site for residue FMT B 305 source : AD3 18) chain B residue 195 type sequence F description binding site for residue FMT B 305 source : AD3 19) chain B residue 49 type sequence Q description binding site for residue FMT B 306 source : AD4 20) chain B residue 59 type sequence Q description binding site for residue FMT B 306 source : AD4 21) chain B residue 63 type sequence A description binding site for residue FMT B 306 source : AD4 22) chain B residue 156 type sequence Y description binding site for residue FMT B 306 source : AD4 23) chain B residue 184 type sequence Y description binding site for residue FMT B 306 source : AD4 24) chain B residue 185 type sequence R description binding site for residue FMT B 306 source : AD4

Display surface Download Links