eF-site ID 5icp-A PDB Code 5icp Chain A click to enlarge Title CDK8-CYCC IN COMPLEX WITH [(S)-2-(4-Chloro-phenyl)-pyrrolidin-1-yl]-(5-methyl-imidazo[5,1-b][1,3,4]thiadiazol-2-yl)-methanone Classification TRANSFERASE Compound Cyclin-dependent kinase 8 Source Homo sapiens (Human) (CCNC_HUMAN) Sequence A:  MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKR KDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVIS LQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKLPRGM VKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERG RVKIADMGFARLFNSPLKVVTFWYRAPELLLGARHYTKAI DIWAIGCIFAELLTSEPIFHCRQESNPYHHDQLDRIFNVM GFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEK HKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDP LPTSDVFAGCQIPYPKREFLTEE Description Functional site 1) chain A residue 27 type sequence V description binding site for residue 69Z A 401 source : AC1 2) chain A residue 32 type sequence Y description binding site for residue 69Z A 401 source : AC1 3) chain A residue 35 type sequence V description binding site for residue 69Z A 401 source : AC1 4) chain A residue 50 type sequence A description binding site for residue 69Z A 401 source : AC1 5) chain A residue 52 type sequence K description binding site for residue 69Z A 401 source : AC1 6) chain A residue 97 type sequence F description binding site for residue 69Z A 401 source : AC1 7) chain A residue 98 type sequence D description binding site for residue 69Z A 401 source : AC1 8) chain A residue 100 type sequence A description binding site for residue 69Z A 401 source : AC1 9) chain A residue 156 type sequence N description binding site for residue 69Z A 401 source : AC1 10) chain A residue 158 type sequence L description binding site for residue 69Z A 401 source : AC1 11) chain A residue 173 type sequence D description binding site for residue 69Z A 401 source : AC1 12) chain A residue 356 type sequence R description binding site for residue 69Z A 401 source : AC1 13) chain A residue 106 type sequence H description binding site for residue EDO A 402 source : AC2 14) chain A residue 355 type sequence K description binding site for residue EDO A 402 source : AC2 15) chain A residue 356 type sequence R description binding site for residue EDO A 402 source : AC2 16) chain A residue 357 type sequence E description binding site for residue EDO A 402 source : AC2 17) chain A residue 71 type sequence R description binding site for residue EDO A 403 source : AC3 18) chain A residue 83 type sequence K description binding site for residue EDO A 403 source : AC3 19) chain A residue 84 type sequence V description binding site for residue EDO A 403 source : AC3 20) chain A residue 66 type sequence E description binding site for residue EDO A 404 source : AC4 21) chain A residue 70 type sequence L description binding site for residue EDO A 404 source : AC4 22) chain A residue 79 type sequence I description binding site for residue EDO A 404 source : AC4 23) chain A residue 97 type sequence F description binding site for residue EDO A 404 source : AC4 24) chain A residue 172 type sequence A description binding site for residue EDO A 404 source : AC4 25) chain A residue 173 type sequence D description binding site for residue EDO A 404 source : AC4 26) chain A residue 176 type sequence F description binding site for residue EDO A 404 source : AC4 27) chain A residue 71 type sequence R description binding site for residue FMT A 405 source : AC5 28) chain A residue 72 type sequence E description binding site for residue FMT A 405 source : AC5 29) chain A residue 8 type sequence K description binding site for residue FMT A 406 source : AC6 30) chain A residue 262 type sequence P description binding site for residue FMT A 406 source : AC6 31) chain A residue 264 type sequence D description binding site for residue FMT A 406 source : AC6 32) chain A residue 276 type sequence H description binding site for residue FMT A 406 source : AC6 33) chain A residue 280 type sequence M description binding site for residue FMT A 406 source : AC6 34) chain A residue 285 type sequence R description binding site for residue FMT A 406 source : AC6 35) chain A residue 17 type sequence E description binding site for residue FMT A 407 source : AC7 36) chain A residue 20 type sequence F description binding site for residue FMT A 407 source : AC7 37) chain A residue 21 type sequence E description binding site for residue FMT A 407 source : AC7 38) chain A residue 22 type sequence Y description binding site for residue FMT A 407 source : AC7 39) chain A residue 23 type sequence E description binding site for residue FMT A 407 source : AC7 40) chain A residue 41 type sequence K description binding site for residue FMT A 407 source : AC7 41) chain A residue 27-52 type prosite sequence VGRGTYGHVYKAKRKDGKDDKDYALK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGTYGHVYkAkrkdgkddkd........YALK source prosite : PS00107 42) chain A residue 147-159 type prosite sequence VLHRDLKPANILV description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpaNILV source prosite : PS00108 43) chain A residue 151 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 44) chain A residue 27 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 45) chain A residue 52 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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