eF-site ID 5icn-ABC PDB Code 5icn Chain A, B, C click to enlarge Title HDAC1:MTA1 in complex with inositol-6-phosphate and a novel peptide inhibitor based on histone H4 Classification TRANSCRIPTION Compound Metastasis-associated protein MTA1 Source (5ICN) Sequence A:  GEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNP LTDKQIDQFLVVARSVGTFARALDSLHMSAAAASRDITLF HAMDTLHKNIYDISKAISALVPQGGPVLCRDEMEEWSASE ANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKT TDRYVQQK B:  RRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGL YRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEY SKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQ QTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYH QRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPG TGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSK VMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEF VKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNE LPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLF ENLRMLPHA C:  GAXRH Description Functional site 1) chain A residue 305 type sequence K description binding site for residue IHP A 401 source : AC1 2) chain A residue 327 type sequence Y description binding site for residue IHP A 401 source : AC1 3) chain A residue 328 type sequence Y description binding site for residue IHP A 401 source : AC1 4) chain A residue 331 type sequence K description binding site for residue IHP A 401 source : AC1 5) chain B residue 27 type sequence G description binding site for residue IHP A 401 source : AC1 6) chain B residue 31 type sequence K description binding site for residue IHP A 401 source : AC1 7) chain B residue 270 type sequence R description binding site for residue IHP A 401 source : AC1 8) chain B residue 305 type sequence I description binding site for residue IHP A 401 source : AC1 9) chain B residue 176 type sequence D description binding site for residue ZN B 401 source : AC2 10) chain B residue 178 type sequence H description binding site for residue ZN B 401 source : AC2 11) chain B residue 264 type sequence D description binding site for residue ZN B 401 source : AC2 12) chain C residue 16 type sequence X description binding site for residue ZN B 401 source : AC2 13) chain B residue 174 type sequence D description binding site for residue K B 402 source : AC3 14) chain B residue 176 type sequence D description binding site for residue K B 402 source : AC3 15) chain B residue 178 type sequence H description binding site for residue K B 402 source : AC3 16) chain B residue 197 type sequence S description binding site for residue K B 402 source : AC3 17) chain B residue 198 type sequence F description binding site for residue K B 402 source : AC3 18) chain B residue 187 type sequence F description binding site for residue K B 403 source : AC4 19) chain B residue 190 type sequence T description binding site for residue K B 403 source : AC4 20) chain B residue 193 type sequence V description binding site for residue K B 403 source : AC4 21) chain B residue 222 type sequence Y description binding site for residue K B 403 source : AC4 22) chain B residue 74 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:Q92769 source Swiss-Prot : SWS_FT_FI5 23) chain B residue 141 type ACT_SITE sequence H description ACT_SITE => ECO:0000269|PubMed:19182791, ECO:0000269|PubMed:28497810 source Swiss-Prot : SWS_FT_FI1 24) chain B residue 74 type MOD_RES sequence K description N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 25) chain B residue 220 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 26) chain B residue 261 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000250|UniProtKB:P70288 source Swiss-Prot : SWS_FT_FI4 27) chain B residue 273 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000250|UniProtKB:P70288 source Swiss-Prot : SWS_FT_FI4

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