eF-site ID 5ia0-C PDB Code 5ia0 Chain C click to enlarge Title Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with alisertib (MLN8237) Classification TRANSFERASE Compound Ephrin type-A receptor 2 Source (EPHA2_HUMAN) Sequence C:  AVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTGKKEV PVAIKTLKATEKQRVDFLGEAGIMGQFSHHNIIRLEGVIS KYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGI AAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSPI RWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWEL SNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARR PKFADIVSILDKLIRAPDSLKTLADFDPR Description Functional site 1) chain C residue 888 type sequence D description binding site for residue EDO A 1005 source : AC5 2) chain C residue 890 type sequence R description binding site for residue EDO A 1005 source : AC5 3) chain C residue 616 type sequence Q description binding site for residue EDO B 1002 source : AC9 4) chain C residue 619 type sequence I description binding site for residue A5B C 1001 source : AD9 5) chain C residue 621 type sequence A description binding site for residue A5B C 1001 source : AD9 6) chain C residue 644 type sequence A description binding site for residue A5B C 1001 source : AD9 7) chain C residue 646 type sequence K description binding site for residue A5B C 1001 source : AD9 8) chain C residue 694 type sequence Y description binding site for residue A5B C 1001 source : AD9 9) chain C residue 695 type sequence M description binding site for residue A5B C 1001 source : AD9 10) chain C residue 696 type sequence E description binding site for residue A5B C 1001 source : AD9 11) chain C residue 698 type sequence G description binding site for residue A5B C 1001 source : AD9 12) chain C residue 702 type sequence K description binding site for residue A5B C 1001 source : AD9 13) chain C residue 743 type sequence R description binding site for residue A5B C 1001 source : AD9 14) chain C residue 744 type sequence N description binding site for residue A5B C 1001 source : AD9 15) chain C residue 746 type sequence L description binding site for residue A5B C 1001 source : AD9 16) chain C residue 756 type sequence S description binding site for residue A5B C 1001 source : AD9 17) chain C residue 604 type sequence F description binding site for residue EDO C 1002 source : AE1 18) chain C residue 605 type sequence T description binding site for residue EDO C 1002 source : AE1 19) chain C residue 606 type sequence T description binding site for residue EDO C 1002 source : AE1 20) chain C residue 668 type sequence G description binding site for residue EDO C 1002 source : AE1 21) chain C residue 678 type sequence L description binding site for residue EDO C 1002 source : AE1 22) chain C residue 679 type sequence E description binding site for residue EDO C 1002 source : AE1 23) chain C residue 680 type sequence G description binding site for residue EDO C 1002 source : AE1 24) chain C residue 617 type sequence K description binding site for residue EDO C 1003 source : AE2 25) chain C residue 619 type sequence I description binding site for residue EDO C 1003 source : AE2 26) chain C residue 694 type sequence Y description binding site for residue EDO C 1003 source : AE2 27) chain C residue 738 type sequence R description binding site for residue EDO C 1004 source : AE3 28) chain C residue 731 type sequence A description binding site for residue EDO C 1005 source : AE4 29) chain C residue 863 type sequence K description binding site for residue EDO C 1005 source : AE4 30) chain C residue 864 type sequence F description binding site for residue EDO C 1005 source : AE4 31) chain C residue 865 type sequence A description binding site for residue EDO C 1005 source : AE4 32) chain C residue 852 type sequence Q description binding site for residue EDO C 1006 source : AE5 33) chain C residue 860 type sequence R description binding site for residue EDO C 1006 source : AE5 34) chain C residue 735 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000250|UniProtKB:Q03145 source Swiss-Prot : SWS_FT_FI5 35) chain C residue 869 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI7 36) chain C residue 739 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 37) chain C residue 619 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 38) chain C residue 646 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 39) chain C residue 628 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI3 40) chain C residue 647 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI4

Display surface Download Links