eF-site ID 5ia0-B PDB Code 5ia0 Chain B click to enlarge Title Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with alisertib (MLN8237) Classification TRANSFERASE Compound Ephrin type-A receptor 2 Source (EPHA2_HUMAN) Sequence B:  AVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSKEVP VAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVI SKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRG IAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSR VLIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGER PYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQ ERARRPKFADIVSILDKLIRAPDSLK Description Functional site 1) chain B residue 619 type sequence I description binding site for residue A5B B 1001 source : AC8 2) chain B residue 621 type sequence A description binding site for residue A5B B 1001 source : AC8 3) chain B residue 644 type sequence A description binding site for residue A5B B 1001 source : AC8 4) chain B residue 646 type sequence K description binding site for residue A5B B 1001 source : AC8 5) chain B residue 663 type sequence E description binding site for residue A5B B 1001 source : AC8 6) chain B residue 694 type sequence Y description binding site for residue A5B B 1001 source : AC8 7) chain B residue 695 type sequence M description binding site for residue A5B B 1001 source : AC8 8) chain B residue 696 type sequence E description binding site for residue A5B B 1001 source : AC8 9) chain B residue 698 type sequence G description binding site for residue A5B B 1001 source : AC8 10) chain B residue 702 type sequence K description binding site for residue A5B B 1001 source : AC8 11) chain B residue 744 type sequence N description binding site for residue A5B B 1001 source : AC8 12) chain B residue 746 type sequence L description binding site for residue A5B B 1001 source : AC8 13) chain B residue 756 type sequence S description binding site for residue A5B B 1001 source : AC8 14) chain B residue 835 type sequence R description binding site for residue EDO B 1002 source : AC9 15) chain B residue 750 type sequence N description binding site for residue EDO B 1003 source : AD1 16) chain B residue 705 type sequence R description binding site for residue EDO B 1004 source : AD2 17) chain B residue 708 type sequence D description binding site for residue EDO B 1004 source : AD2 18) chain B residue 812 type sequence T description binding site for residue EDO B 1004 source : AD2 19) chain B residue 813 type sequence Y description binding site for residue EDO B 1004 source : AD2 20) chain B residue 693 type sequence E description binding site for residue EDO B 1005 source : AD3 21) chain B residue 694 type sequence Y description binding site for residue EDO B 1005 source : AD3 22) chain B residue 695 type sequence M description binding site for residue EDO B 1005 source : AD3 23) chain B residue 696 type sequence E description binding site for residue EDO B 1005 source : AD3 24) chain B residue 748 type sequence N description binding site for residue EDO B 1005 source : AD3 25) chain B residue 705 type sequence R description binding site for residue EDO B 1006 source : AD4 26) chain B residue 706 type sequence E description binding site for residue EDO B 1006 source : AD4 27) chain B residue 670 type sequence F description binding site for residue EDO B 1007 source : AD5 28) chain B residue 677 type sequence R description binding site for residue EDO B 1007 source : AD5 29) chain B residue 678 type sequence L description binding site for residue EDO B 1007 source : AD5 30) chain B residue 617 type sequence K description binding site for residue EDO B 1008 source : AD6 31) chain B residue 619 type sequence I description binding site for residue EDO B 1008 source : AD6 32) chain B residue 601 type sequence V description binding site for residue EDO B 1009 source : AD7 33) chain B residue 602 type sequence L description binding site for residue EDO B 1009 source : AD7 34) chain B residue 603 type sequence K description binding site for residue EDO B 1009 source : AD7 35) chain B residue 604 type sequence F description binding site for residue EDO B 1009 source : AD7 36) chain B residue 731 type sequence A description binding site for residue EDO B 1010 source : AD8 37) chain B residue 863 type sequence K description binding site for residue EDO B 1010 source : AD8 38) chain B residue 864 type sequence F description binding site for residue EDO B 1010 source : AD8 39) chain B residue 865 type sequence A description binding site for residue EDO B 1010 source : AD8 40) chain B residue 735 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000250|UniProtKB:Q03145 source Swiss-Prot : SWS_FT_FI5 41) chain B residue 869 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI7 42) chain B residue 739 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 43) chain B residue 619 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 44) chain B residue 646 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 45) chain B residue 628 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI3 46) chain B residue 647 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI4

Display surface Download Links