eF-site ID 5i4r-ABCDEFGH PDB Code 5i4r Chain A, B, C, D, E, F, G, H click to enlarge Title Contact-dependent inhibition system from Escherichia coli NC101 - ternary CdiA/CdiI/EF-Tu complex (trypsin-modified) Classification TOXIN/ANTITOXIN Compound Contact-dependent inhibitor A Source ORGANISM_SCIENTIFIC: Escherichia coli; Sequence A:  GIGKKISFDGDFYTVDGXKFSKSYYEKLWEQGRPAPFVQA REVLNSNPKIEPDPRGAPGYLRYEGAGLEXIYNPKTGQVG HIQPVKV B:  DIWPEFQRDLEXYRDVVLSIKRNLRLYEECIESLVHQIGS TNFDNAQPLFDDLFRXQSELATXLYKYEYKPGKRIQDLIY HLDRDDFYSRKYWHKKFSDGLAWPEAG C:  TKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGG D:  GITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQM DGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCD MVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKAL EGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLPIEDVF SISGRGTVVTGRVERGIIKVGEEVEIVGIKETQKSTCTGV EMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTI KPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVT GTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIRE GGRTVGAGVVAKVLG E:  IGKKISFDGDFYTVDGXKFSKSYYEKLWEQGRPAPFVQAR EVLNSNPKIEPDPRGAPGYLRYEGAGLEXIYNPKTGQVGH IQPVKV F:  DIWPEFQRDLEXYRDVVLSIKRNLRLYEECIESLVHQIGS TNFDNAQPLFDDLFRXQSELATXLYKYEYKPGKRIQDLIY HLDRDDFYSRKYWHKKFSDGLAWPEA G:  KPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGG H:  GITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQM DGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCD MVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKAL EGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLPIEDVF SISGRGTVVTGRVERGIIKVGEEVEIVGIKETQKSTCTGV EMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTI KPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVT GTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIRE GGRTVGAGVVAKVLG Description Functional site 1) chain C residue 22 type sequence D description binding site for residue GDP C 101 source : AC1 2) chain C residue 24 type sequence G description binding site for residue GDP C 101 source : AC1 3) chain C residue 25 type sequence K description binding site for residue GDP C 101 source : AC1 4) chain C residue 26 type sequence T description binding site for residue GDP C 101 source : AC1 5) chain C residue 27 type sequence T description binding site for residue GDP C 101 source : AC1 6) chain D residue 136 type sequence N description binding site for residue GDP C 101 source : AC1 7) chain D residue 137 type sequence K description binding site for residue GDP C 101 source : AC1 8) chain D residue 139 type sequence D description binding site for residue GDP C 101 source : AC1 9) chain D residue 140 type sequence M description binding site for residue GDP C 101 source : AC1 10) chain D residue 174 type sequence S description binding site for residue GDP C 101 source : AC1 11) chain D residue 175 type sequence A description binding site for residue GDP C 101 source : AC1 12) chain D residue 176 type sequence L description binding site for residue GDP C 101 source : AC1 13) chain G residue 22 type sequence D description binding site for residue GDP G 101 source : AC2 14) chain G residue 23 type sequence H description binding site for residue GDP G 101 source : AC2 15) chain G residue 24 type sequence G description binding site for residue GDP G 101 source : AC2 16) chain G residue 25 type sequence K description binding site for residue GDP G 101 source : AC2 17) chain G residue 26 type sequence T description binding site for residue GDP G 101 source : AC2 18) chain G residue 27 type sequence T description binding site for residue GDP G 101 source : AC2 19) chain H residue 136 type sequence N description binding site for residue GDP G 101 source : AC2 20) chain H residue 137 type sequence K description binding site for residue GDP G 101 source : AC2 21) chain H residue 139 type sequence D description binding site for residue GDP G 101 source : AC2 22) chain H residue 140 type sequence M description binding site for residue GDP G 101 source : AC2 23) chain H residue 174 type sequence S description binding site for residue GDP G 101 source : AC2 24) chain H residue 175 type sequence A description binding site for residue GDP G 101 source : AC2 25) chain H residue 176 type sequence L description binding site for residue GDP G 101 source : AC2 26) chain D residue 314 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:18723842 source Swiss-Prot : SWS_FT_FI2 27) chain H residue 314 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:18723842 source Swiss-Prot : SWS_FT_FI2 28) chain D residue 383 type MOD_RES sequence T description Phosphothreonine => ECO:0000269|PubMed:19150849, ECO:0000269|PubMed:24141193, ECO:0000269|PubMed:8416965 source Swiss-Prot : SWS_FT_FI3 29) chain H residue 383 type MOD_RES sequence T description Phosphothreonine => ECO:0000269|PubMed:19150849, ECO:0000269|PubMed:24141193, ECO:0000269|PubMed:8416965 source Swiss-Prot : SWS_FT_FI3 30) chain D residue 85 type catalytic sequence H description 535 source MCSA : MCSA1 31) chain H residue 85 type catalytic sequence H description 535 source MCSA : MCSA2 32) chain H residue 81 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 33) chain H residue 136 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 34) chain D residue 81 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 35) chain D residue 136 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1

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