eF-site ID 5ht4-A PDB Code 5ht4 Chain A click to enlarge Title 6-substituted pyrrolo[2,3-d]pyrimidine 6-thieno-(4-methoxyphenyl) Classification oxidoreductase/oxidoreductase inhibitor Compound Dihydrofolate reductase Source Homo sapiens (Human) (DYR_HUMAN) Sequence A:  VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTT SSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELK EPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSV YKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLP EYPGVLSDVQEEKGIKYKFEVYEKND Description Functional site 1) chain A residue 7 type sequence I description binding site for residue 65J A 201 source : AC1 2) chain A residue 8 type sequence V description binding site for residue 65J A 201 source : AC1 3) chain A residue 9 type sequence A description binding site for residue 65J A 201 source : AC1 4) chain A residue 30 type sequence E description binding site for residue 65J A 201 source : AC1 5) chain A residue 31 type sequence F description binding site for residue 65J A 201 source : AC1 6) chain A residue 34 type sequence F description binding site for residue 65J A 201 source : AC1 7) chain A residue 64 type sequence N description binding site for residue 65J A 201 source : AC1 8) chain A residue 115 type sequence V description binding site for residue 65J A 201 source : AC1 9) chain A residue 121 type sequence Y description binding site for residue 65J A 201 source : AC1 10) chain A residue 136 type sequence T description binding site for residue 65J A 201 source : AC1 11) chain A residue 8 type sequence V description binding site for residues NDP A 202 and SO4 A 203 source : AC2 12) chain A residue 9 type sequence A description binding site for residues NDP A 202 and SO4 A 203 source : AC2 13) chain A residue 16 type sequence I description binding site for residues NDP A 202 and SO4 A 203 source : AC2 14) chain A residue 17 type sequence G description binding site for residues NDP A 202 and SO4 A 203 source : AC2 15) chain A residue 20 type sequence G description binding site for residues NDP A 202 and SO4 A 203 source : AC2 16) chain A residue 21 type sequence D description binding site for residues NDP A 202 and SO4 A 203 source : AC2 17) chain A residue 53 type sequence G description binding site for residues NDP A 202 and SO4 A 203 source : AC2 18) chain A residue 54 type sequence K description binding site for residues NDP A 202 and SO4 A 203 source : AC2 19) chain A residue 55 type sequence K description binding site for residues NDP A 202 and SO4 A 203 source : AC2 20) chain A residue 56 type sequence T description binding site for residues NDP A 202 and SO4 A 203 source : AC2 21) chain A residue 59 type sequence S description binding site for residues NDP A 202 and SO4 A 203 source : AC2 22) chain A residue 75 type sequence L description binding site for residues NDP A 202 and SO4 A 203 source : AC2 23) chain A residue 76 type sequence S description binding site for residues NDP A 202 and SO4 A 203 source : AC2 24) chain A residue 77 type sequence R description binding site for residues NDP A 202 and SO4 A 203 source : AC2 25) chain A residue 78 type sequence E description binding site for residues NDP A 202 and SO4 A 203 source : AC2 26) chain A residue 91 type sequence R description binding site for residues NDP A 202 and SO4 A 203 source : AC2 27) chain A residue 92 type sequence S description binding site for residues NDP A 202 and SO4 A 203 source : AC2 28) chain A residue 93 type sequence L description binding site for residues NDP A 202 and SO4 A 203 source : AC2 29) chain A residue 115 type sequence V description binding site for residues NDP A 202 and SO4 A 203 source : AC2 30) chain A residue 117 type sequence G description binding site for residues NDP A 202 and SO4 A 203 source : AC2 31) chain A residue 118 type sequence S description binding site for residues NDP A 202 and SO4 A 203 source : AC2 32) chain A residue 119 type sequence S description binding site for residues NDP A 202 and SO4 A 203 source : AC2 33) chain A residue 120 type sequence V description binding site for residues NDP A 202 and SO4 A 203 source : AC2 34) chain A residue 121 type sequence Y description binding site for residues NDP A 202 and SO4 A 203 source : AC2 35) chain A residue 146 type sequence T description binding site for residues NDP A 202 and SO4 A 203 source : AC2 36) chain A residue 8 type sequence V description binding site for residues NDP A 202 and SO4 A 203 source : AC3 37) chain A residue 9 type sequence A description binding site for residues NDP A 202 and SO4 A 203 source : AC3 38) chain A residue 16 type sequence I description binding site for residues NDP A 202 and SO4 A 203 source : AC3 39) chain A residue 17 type sequence G description binding site for residues NDP A 202 and SO4 A 203 source : AC3 40) chain A residue 20 type sequence G description binding site for residues NDP A 202 and SO4 A 203 source : AC3 41) chain A residue 21 type sequence D description binding site for residues NDP A 202 and SO4 A 203 source : AC3 42) chain A residue 53 type sequence G description binding site for residues NDP A 202 and SO4 A 203 source : AC3 43) chain A residue 54 type sequence K description binding site for residues NDP A 202 and SO4 A 203 source : AC3 44) chain A residue 55 type sequence K description binding site for residues NDP A 202 and SO4 A 203 source : AC3 45) chain A residue 56 type sequence T description binding site for residues NDP A 202 and SO4 A 203 source : AC3 46) chain A residue 59 type sequence S description binding site for residues NDP A 202 and SO4 A 203 source : AC3 47) chain A residue 75 type sequence L description binding site for residues NDP A 202 and SO4 A 203 source : AC3 48) chain A residue 76 type sequence S description binding site for residues NDP A 202 and SO4 A 203 source : AC3 49) chain A residue 77 type sequence R description binding site for residues NDP A 202 and SO4 A 203 source : AC3 50) chain A residue 78 type sequence E description binding site for residues NDP A 202 and SO4 A 203 source : AC3 51) chain A residue 91 type sequence R description binding site for residues NDP A 202 and SO4 A 203 source : AC3 52) chain A residue 92 type sequence S description binding site for residues NDP A 202 and SO4 A 203 source : AC3 53) chain A residue 93 type sequence L description binding site for residues NDP A 202 and SO4 A 203 source : AC3 54) chain A residue 115 type sequence V description binding site for residues NDP A 202 and SO4 A 203 source : AC3 55) chain A residue 117 type sequence G description binding site for residues NDP A 202 and SO4 A 203 source : AC3 56) chain A residue 118 type sequence S description binding site for residues NDP A 202 and SO4 A 203 source : AC3 57) chain A residue 119 type sequence S description binding site for residues NDP A 202 and SO4 A 203 source : AC3 58) chain A residue 120 type sequence V description binding site for residues NDP A 202 and SO4 A 203 source : AC3 59) chain A residue 121 type sequence Y description binding site for residues NDP A 202 and SO4 A 203 source : AC3 60) chain A residue 146 type sequence T description binding site for residues NDP A 202 and SO4 A 203 source : AC3 61) chain A residue 8 type sequence V description binding site for residues NDP A 202 and SO4 A 203 source : AC4 62) chain A residue 9 type sequence A description binding site for residues NDP A 202 and SO4 A 203 source : AC4 63) chain A residue 16 type sequence I description binding site for residues NDP A 202 and SO4 A 203 source : AC4 64) chain A residue 17 type sequence G description binding site for residues NDP A 202 and SO4 A 203 source : AC4 65) chain A residue 20 type sequence G description binding site for residues NDP A 202 and SO4 A 203 source : AC4 66) chain A residue 21 type sequence D description binding site for residues NDP A 202 and SO4 A 203 source : AC4 67) chain A residue 53 type sequence G description binding site for residues NDP A 202 and SO4 A 203 source : AC4 68) chain A residue 54 type sequence K description binding site for residues NDP A 202 and SO4 A 203 source : AC4 69) chain A residue 55 type sequence K description binding site for residues NDP A 202 and SO4 A 203 source : AC4 70) chain A residue 56 type sequence T description binding site for residues NDP A 202 and SO4 A 203 source : AC4 71) chain A residue 59 type sequence S description binding site for residues NDP A 202 and SO4 A 203 source : AC4 72) chain A residue 75 type sequence L description binding site for residues NDP A 202 and SO4 A 203 source : AC4 73) chain A residue 76 type sequence S description binding site for residues NDP A 202 and SO4 A 203 source : AC4 74) chain A residue 77 type sequence R description binding site for residues NDP A 202 and SO4 A 203 source : AC4 75) chain A residue 78 type sequence E description binding site for residues NDP A 202 and SO4 A 203 source : AC4 76) chain A residue 91 type sequence R description binding site for residues NDP A 202 and SO4 A 203 source : AC4 77) chain A residue 92 type sequence S description binding site for residues NDP A 202 and SO4 A 203 source : AC4 78) chain A residue 93 type sequence L description binding site for residues NDP A 202 and SO4 A 203 source : AC4 79) chain A residue 115 type sequence V description binding site for residues NDP A 202 and SO4 A 203 source : AC4 80) chain A residue 117 type sequence G description binding site for residues NDP A 202 and SO4 A 203 source : AC4 81) chain A residue 118 type sequence S description binding site for residues NDP A 202 and SO4 A 203 source : AC4 82) chain A residue 119 type sequence S description binding site for residues NDP A 202 and SO4 A 203 source : AC4 83) chain A residue 120 type sequence V description binding site for residues NDP A 202 and SO4 A 203 source : AC4 84) chain A residue 121 type sequence Y description binding site for residues NDP A 202 and SO4 A 203 source : AC4 85) chain A residue 146 type sequence T description binding site for residues NDP A 202 and SO4 A 203 source : AC4 86) chain A residue 8 type sequence V description binding site for residues NDP A 202 and SO4 A 203 source : AC5 87) chain A residue 9 type sequence A description binding site for residues NDP A 202 and SO4 A 203 source : AC5 88) chain A residue 16 type sequence I description binding site for residues NDP A 202 and SO4 A 203 source : AC5 89) chain A residue 17 type sequence G description binding site for residues NDP A 202 and SO4 A 203 source : AC5 90) chain A residue 20 type sequence G description binding site for residues NDP A 202 and SO4 A 203 source : AC5 91) chain A residue 21 type sequence D description binding site for residues NDP A 202 and SO4 A 203 source : AC5 92) chain A residue 53 type sequence G description binding site for residues NDP A 202 and SO4 A 203 source : AC5 93) chain A residue 54 type sequence K description binding site for residues NDP A 202 and SO4 A 203 source : AC5 94) chain A residue 55 type sequence K description binding site for residues NDP A 202 and SO4 A 203 source : AC5 95) chain A residue 56 type sequence T description binding site for residues NDP A 202 and SO4 A 203 source : AC5 96) chain A residue 59 type sequence S description binding site for residues NDP A 202 and SO4 A 203 source : AC5 97) chain A residue 75 type sequence L description binding site for residues NDP A 202 and SO4 A 203 source : AC5 98) chain A residue 76 type sequence S description binding site for residues NDP A 202 and SO4 A 203 source : AC5 99) chain A residue 77 type sequence R description binding site for residues NDP A 202 and SO4 A 203 source : AC5 100) chain A residue 78 type sequence E description binding site for residues NDP A 202 and SO4 A 203 source : AC5 101) chain A residue 91 type sequence R description binding site for residues NDP A 202 and SO4 A 203 source : AC5 102) chain A residue 92 type sequence S description binding site for residues NDP A 202 and SO4 A 203 source : AC5 103) chain A residue 93 type sequence L description binding site for residues NDP A 202 and SO4 A 203 source : AC5 104) chain A residue 115 type sequence V description binding site for residues NDP A 202 and SO4 A 203 source : AC5 105) chain A residue 117 type sequence G description binding site for residues NDP A 202 and SO4 A 203 source : AC5 106) chain A residue 118 type sequence S description binding site for residues NDP A 202 and SO4 A 203 source : AC5 107) chain A residue 119 type sequence S description binding site for residues NDP A 202 and SO4 A 203 source : AC5 108) chain A residue 120 type sequence V description binding site for residues NDP A 202 and SO4 A 203 source : AC5 109) chain A residue 121 type sequence Y description binding site for residues NDP A 202 and SO4 A 203 source : AC5 110) chain A residue 146 type sequence T description binding site for residues NDP A 202 and SO4 A 203 source : AC5 111) chain A residue 8 type sequence V description binding site for residues NDP A 202 and SO4 A 204 source : AC6 112) chain A residue 9 type sequence A description binding site for residues NDP A 202 and SO4 A 204 source : AC6 113) chain A residue 16 type sequence I description binding site for residues NDP A 202 and SO4 A 204 source : AC6 114) chain A residue 17 type sequence G description binding site for residues NDP A 202 and SO4 A 204 source : AC6 115) chain A residue 20 type sequence G description binding site for residues NDP A 202 and SO4 A 204 source : AC6 116) chain A residue 21 type sequence D description binding site for residues NDP A 202 and SO4 A 204 source : AC6 117) chain A residue 53 type sequence G description binding site for residues NDP A 202 and SO4 A 204 source : AC6 118) chain A residue 54 type sequence K description binding site for residues NDP A 202 and SO4 A 204 source : AC6 119) chain A residue 55 type sequence K description binding site for residues NDP A 202 and SO4 A 204 source : AC6 120) chain A residue 56 type sequence T description binding site for residues NDP A 202 and SO4 A 204 source : AC6 121) chain A residue 59 type sequence S description binding site for residues NDP A 202 and SO4 A 204 source : AC6 122) chain A residue 75 type sequence L description binding site for residues NDP A 202 and SO4 A 204 source : AC6 123) chain A residue 76 type sequence S description binding site for residues NDP A 202 and SO4 A 204 source : AC6 124) chain A residue 77 type sequence R description binding site for residues NDP A 202 and SO4 A 204 source : AC6 125) chain A residue 78 type sequence E description binding site for residues NDP A 202 and SO4 A 204 source : AC6 126) chain A residue 91 type sequence R description binding site for residues NDP A 202 and SO4 A 204 source : AC6 127) chain A residue 92 type sequence S description binding site for residues NDP A 202 and SO4 A 204 source : AC6 128) chain A residue 93 type sequence L description binding site for residues NDP A 202 and SO4 A 204 source : AC6 129) chain A residue 115 type sequence V description binding site for residues NDP A 202 and SO4 A 204 source : AC6 130) chain A residue 117 type sequence G description binding site for residues NDP A 202 and SO4 A 204 source : AC6 131) chain A residue 118 type sequence S description binding site for residues NDP A 202 and SO4 A 204 source : AC6 132) chain A residue 119 type sequence S description binding site for residues NDP A 202 and SO4 A 204 source : AC6 133) chain A residue 120 type sequence V description binding site for residues NDP A 202 and SO4 A 204 source : AC6 134) chain A residue 121 type sequence Y description binding site for residues NDP A 202 and SO4 A 204 source : AC6 135) chain A residue 146 type sequence T description binding site for residues NDP A 202 and SO4 A 204 source : AC6 136) chain A residue 8 type sequence V description binding site for residues NDP A 202 and SO4 A 204 source : AC7 137) chain A residue 9 type sequence A description binding site for residues NDP A 202 and SO4 A 204 source : AC7 138) chain A residue 16 type sequence I description binding site for residues NDP A 202 and SO4 A 204 source : AC7 139) chain A residue 17 type sequence G description binding site for residues NDP A 202 and SO4 A 204 source : AC7 140) chain A residue 20 type sequence G description binding site for residues NDP A 202 and SO4 A 204 source : AC7 141) chain A residue 21 type sequence D description binding site for residues NDP A 202 and SO4 A 204 source : AC7 142) chain A residue 53 type sequence G description binding site for residues NDP A 202 and SO4 A 204 source : AC7 143) chain A residue 54 type sequence K description binding site for residues NDP A 202 and SO4 A 204 source : AC7 144) chain A residue 55 type sequence K description binding site for residues NDP A 202 and SO4 A 204 source : AC7 145) chain A residue 56 type sequence T description binding site for residues NDP A 202 and SO4 A 204 source : AC7 146) chain A residue 59 type sequence S description binding site for residues NDP A 202 and SO4 A 204 source : AC7 147) chain A residue 75 type sequence L description binding site for residues NDP A 202 and SO4 A 204 source : AC7 148) chain A residue 76 type sequence S description binding site for residues NDP A 202 and SO4 A 204 source : AC7 149) chain A residue 77 type sequence R description binding site for residues NDP A 202 and SO4 A 204 source : AC7 150) chain A residue 78 type sequence E description binding site for residues NDP A 202 and SO4 A 204 source : AC7 151) chain A residue 91 type sequence R description binding site for residues NDP A 202 and SO4 A 204 source : AC7 152) chain A residue 92 type sequence S description binding site for residues NDP A 202 and SO4 A 204 source : AC7 153) chain A residue 93 type sequence L description binding site for residues NDP A 202 and SO4 A 204 source : AC7 154) chain A residue 115 type sequence V description binding site for residues NDP A 202 and SO4 A 204 source : AC7 155) chain A residue 117 type sequence G description binding site for residues NDP A 202 and SO4 A 204 source : AC7 156) chain A residue 118 type sequence S description binding site for residues NDP A 202 and SO4 A 204 source : AC7 157) chain A residue 119 type sequence S description binding site for residues NDP A 202 and SO4 A 204 source : AC7 158) chain A residue 120 type sequence V description binding site for residues NDP A 202 and SO4 A 204 source : AC7 159) chain A residue 121 type sequence Y description binding site for residues NDP A 202 and SO4 A 204 source : AC7 160) chain A residue 146 type sequence T description binding site for residues NDP A 202 and SO4 A 204 source : AC7 161) chain A residue 15-38 type prosite sequence GIGKNGDLPWPPLRNEFRYFQRMT description DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGkngdLPWpplrnEfryFqrmT source prosite : PS00075 162) chain A residue 116 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15039552, ECO:0000269|PubMed:16222560, ECO:0000269|PubMed:19478082 source Swiss-Prot : SWS_FT_FI1 163) chain A residue 9 type BINDING sequence A description BINDING => ECO:0000269|PubMed:15039552, ECO:0000269|PubMed:16222560, ECO:0000269|PubMed:19478082 source Swiss-Prot : SWS_FT_FI1 164) chain A residue 15 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15039552, ECO:0000269|PubMed:16222560, ECO:0000269|PubMed:19478082 source Swiss-Prot : SWS_FT_FI1 165) chain A residue 54 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15039552, ECO:0000269|PubMed:16222560, ECO:0000269|PubMed:19478082 source Swiss-Prot : SWS_FT_FI1 166) chain A residue 76 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15039552, ECO:0000269|PubMed:16222560, ECO:0000269|PubMed:19478082 source Swiss-Prot : SWS_FT_FI1 167) chain A residue 64 type BINDING sequence N description BINDING => ECO:0000305|PubMed:2248959 source Swiss-Prot : SWS_FT_FI2 168) chain A residue 70 type BINDING sequence R description BINDING => ECO:0000305|PubMed:2248959 source Swiss-Prot : SWS_FT_FI2 169) chain A residue 30 type BINDING sequence E description BINDING => ECO:0000305|PubMed:2248959 source Swiss-Prot : SWS_FT_FI2 170) chain A residue 22 type catalytic sequence L description 490 source MCSA : MCSA1 171) chain A residue 30 type catalytic sequence E description 490 source MCSA : MCSA1

Display surface Download Links