eF-site ID 5ht0-ABCDEF PDB Code 5ht0 Chain A, B, C, D, E, F click to enlarge Title Crystal structure of an Antibiotic_NAT family aminoglycoside acetyltransferase HMB0038 from an uncultured soil metagenomic sample in complex with coenzyme A Classification TRANSFERASE Compound Aminoglycoside acetyltransferase HMB0005 Source uncultured bacterium (A0A059X981_9BACT) Sequence A:  RVSTRSSLAEDLRAIGLADGDAVLVHAALRKVGKIVGGPD DILDAMRDVIGPAGTVLGYADWQLEDEIRDDPAMREHIPA FDPLRSRSIRDNGFWPELIRTTPGALRSASPGASMAAIGG EAEWFTADHALDYGYGPRSPLGKLVEAKGKVLMLGAPLDT MTLLHHAEHLADFPNKRILRYEAPILVDGEKVWRWFEEFD TSDPPDGLADDYFAGIVEEFLATGRGKRGKIGEASSVLVP ADEIVAFAVDWLERWGRTA B:  SRVSTRSSLAEDLRAIGLADGDAVLVHAALRKVGKIVGGP DDILDAMRDVIGPAGTVLGYADWQLEDEIRDDPAMREHIP AFDPLRSRSIRDNGFWPELIRTTPGALRSASPGASMAAIG GEAEWFTADHALDYGYGPRSPLGKLVEAKGKVLMLGAPLD TMTLLHHAEHLADFPNKRILRYEAPILVDGEKVWRWFEEF DTSDPPDGLADDYFAGIVEEFLATGRGKRGKIGEASSVLV PADEIVAFAVDWLERWGRTA C:  SRVSTRSSLAEDLRAIGLADGDAVLVHAALRKVGKIVGGP DDILDAMRDVIGPAGTVLGYADWQLEDEIRDDPAMREHIP AFDPLRSRSIRDNGFWPELIRTTPGALRSASPGASMAAIG GEAEWFTADHALDYGYGPRSPLGKLVEAKGKVLMLGAPLD TMTLLHHAEHLADFPNKRILRYEAPILVDGEKVWRWFEEF DTSDPPDGLADDYFAGIVEEFLATGRGKRGKIGEASSVLV PADEIVAFAVDWLERWGRTAR D:  SRVSTRSSLAEDLRAIGLADGDAVLVHAALRKVGKIVGGP DDILDAMRDVIGPAGTVLGYADWQLEDEIRDDPAMREHIP AFDPLRSRSIRDNGFWPELIRTTPGALRSASPGASMAAIG GEAEWFTADHALDYGYGPRSPLGKLVEAKGKVLMLGAPLD TMTLLHHAEHLADFPNKRILRYEAPILVDGEKVWRWFEEF DTSDPPDGLADDYFAGIVEEFLATGRGKRGKIGEASSVLV PADEIVAFAVDWLERWGRTA E:  SRVSTRSSLAEDLRAIGLADGDAVLVHAALRKVGKIVGGP DDILDAMRDVIGPAGTVLGYADWQLEDEIRDDPAMREHIP AFDPLRSRSIRDNGFWPELIRTTPGALRSASPGASMAAIG GEAEWFTADHALDYGYGPRSPLGKLVEAKGKVLMLGAPLD TMTLLHHAEHLADFPNKRILRYEAPILVDGEKVWRWFEEF DTSDPPDGLADDYFAGIVEEFLATGRGKRGKIGEASSVLV PADEIVAFAVDWLERWGRTAR F:  RVSTRSSLAEDLRAIGLADGDAVLVHAALRKVGKIVGGPD DILDAMRDVIGPAGTVLGYADWQLEDEIRDDPAMREHIPA FDPLRSRSIRDNGFWPELIRTTPGALRSASPGASMAAIGG EAEWFTADHALDYGYGPRSPLGKLVEAKGKVLMLGAPLDT MTLLHHAEHLADFPNKRILRYEAPILVDGEKVWRWFEEFD TSDPPDGLADDYFAGIVEEFLATGRGKRGKIGEASSVLVP ADEIVAFAVDWLERWGRTA Description Functional site 1) chain A residue 29 type sequence H description binding site for residue COA A 301 source : AC1 2) chain A residue 30 type sequence A description binding site for residue COA A 301 source : AC1 3) chain A residue 31 type sequence A description binding site for residue COA A 301 source : AC1 4) chain A residue 32 type sequence L description binding site for residue COA A 301 source : AC1 5) chain A residue 33 type sequence R description binding site for residue COA A 301 source : AC1 6) chain A residue 42 type sequence P description binding site for residue COA A 301 source : AC1 7) chain A residue 62 type sequence Y description binding site for residue COA A 301 source : AC1 8) chain A residue 94 type sequence D description binding site for residue COA A 301 source : AC1 9) chain A residue 95 type sequence N description binding site for residue COA A 301 source : AC1 10) chain A residue 96 type sequence G description binding site for residue COA A 301 source : AC1 11) chain A residue 97 type sequence F description binding site for residue COA A 301 source : AC1 12) chain A residue 160 type sequence P description binding site for residue COA A 301 source : AC1 13) chain A residue 163 type sequence T description binding site for residue COA A 301 source : AC1 14) chain A residue 165 type sequence T description binding site for residue COA A 301 source : AC1 15) chain B residue 66 type sequence Q description binding site for residue COA A 301 source : AC1 16) chain B residue 93 type sequence R description binding site for residue COA A 301 source : AC1 17) chain A residue 131 type sequence D description binding site for residue SO4 A 302 source : AC2 18) chain A residue 133 type sequence A description binding site for residue SO4 A 303 source : AC3 19) chain A residue 134 type sequence L description binding site for residue SO4 A 303 source : AC3 20) chain A residue 135 type sequence D description binding site for residue SO4 A 303 source : AC3 21) chain A residue 141 type sequence R description binding site for residue SO4 A 303 source : AC3 22) chain A residue 21 type sequence A description binding site for residue SO4 A 304 source : AC4 23) chain A residue 22 type sequence D description binding site for residue SO4 A 304 source : AC4 24) chain A residue 66 type sequence Q description binding site for residue COA B 301 source : AC5 25) chain A residue 93 type sequence R description binding site for residue COA B 301 source : AC5 26) chain B residue 29 type sequence H description binding site for residue COA B 301 source : AC5 27) chain B residue 30 type sequence A description binding site for residue COA B 301 source : AC5 28) chain B residue 31 type sequence A description binding site for residue COA B 301 source : AC5 29) chain B residue 32 type sequence L description binding site for residue COA B 301 source : AC5 30) chain B residue 33 type sequence R description binding site for residue COA B 301 source : AC5 31) chain B residue 42 type sequence P description binding site for residue COA B 301 source : AC5 32) chain B residue 62 type sequence Y description binding site for residue COA B 301 source : AC5 33) chain B residue 95 type sequence N description binding site for residue COA B 301 source : AC5 34) chain B residue 96 type sequence G description binding site for residue COA B 301 source : AC5 35) chain B residue 97 type sequence F description binding site for residue COA B 301 source : AC5 36) chain B residue 159 type sequence A description binding site for residue COA B 301 source : AC5 37) chain B residue 131 type sequence D description binding site for residue SO4 B 302 source : AC6 38) chain B residue 133 type sequence A description binding site for residue SO4 B 303 source : AC7 39) chain B residue 134 type sequence L description binding site for residue SO4 B 303 source : AC7 40) chain B residue 135 type sequence D description binding site for residue SO4 B 303 source : AC7 41) chain B residue 141 type sequence R description binding site for residue SO4 B 303 source : AC7 42) chain B residue 21 type sequence A description binding site for residue SO4 B 304 source : AC8 43) chain B residue 22 type sequence D description binding site for residue SO4 B 304 source : AC8 44) chain B residue 8 type sequence R description binding site for residue SO4 B 305 source : AC9 45) chain F residue 260 type sequence R description binding site for residue SO4 B 305 source : AC9 46) chain B residue 78 type sequence R description binding site for residue SO4 B 306 source : AD1 47) chain C residue 29 type sequence H description binding site for residue COA C 301 source : AD2 48) chain C residue 30 type sequence A description binding site for residue COA C 301 source : AD2 49) chain C residue 31 type sequence A description binding site for residue COA C 301 source : AD2 50) chain C residue 32 type sequence L description binding site for residue COA C 301 source : AD2 51) chain C residue 33 type sequence R description binding site for residue COA C 301 source : AD2 52) chain C residue 42 type sequence P description binding site for residue COA C 301 source : AD2 53) chain C residue 95 type sequence N description binding site for residue COA C 301 source : AD2 54) chain C residue 96 type sequence G description binding site for residue COA C 301 source : AD2 55) chain C residue 97 type sequence F description binding site for residue COA C 301 source : AD2 56) chain C residue 159 type sequence A description binding site for residue COA C 301 source : AD2 57) chain C residue 163 type sequence T description binding site for residue COA C 301 source : AD2 58) chain D residue 66 type sequence Q description binding site for residue COA C 301 source : AD2 59) chain D residue 93 type sequence R description binding site for residue COA C 301 source : AD2 60) chain C residue 112 type sequence A description binding site for residue SO4 C 302 source : AD3 61) chain C residue 131 type sequence D description binding site for residue SO4 C 302 source : AD3 62) chain C residue 8 type sequence R description binding site for residue SO4 C 303 source : AD4 63) chain C residue 78 type sequence R description binding site for residue SO4 C 304 source : AD5 64) chain C residue 196 type sequence W description binding site for residue SO4 C 304 source : AD5 65) chain C residue 66 type sequence Q description binding site for residue COA D 301 source : AD6 66) chain C residue 93 type sequence R description binding site for residue COA D 301 source : AD6 67) chain D residue 29 type sequence H description binding site for residue COA D 301 source : AD6 68) chain D residue 30 type sequence A description binding site for residue COA D 301 source : AD6 69) chain D residue 31 type sequence A description binding site for residue COA D 301 source : AD6 70) chain D residue 32 type sequence L description binding site for residue COA D 301 source : AD6 71) chain D residue 33 type sequence R description binding site for residue COA D 301 source : AD6 72) chain D residue 42 type sequence P description binding site for residue COA D 301 source : AD6 73) chain D residue 95 type sequence N description binding site for residue COA D 301 source : AD6 74) chain D residue 97 type sequence F description binding site for residue COA D 301 source : AD6 75) chain D residue 160 type sequence P description binding site for residue COA D 301 source : AD6 76) chain D residue 131 type sequence D description binding site for residue SO4 D 302 source : AD7 77) chain D residue 8 type sequence R description binding site for residue SO4 D 303 source : AD8 78) chain D residue 21 type sequence A description binding site for residue SO4 D 304 source : AD9 79) chain D residue 22 type sequence D description binding site for residue SO4 D 304 source : AD9 80) chain E residue 29 type sequence H description binding site for residue COA E 301 source : AE1 81) chain E residue 30 type sequence A description binding site for residue COA E 301 source : AE1 82) chain E residue 31 type sequence A description binding site for residue COA E 301 source : AE1 83) chain E residue 32 type sequence L description binding site for residue COA E 301 source : AE1 84) chain E residue 33 type sequence R description binding site for residue COA E 301 source : AE1 85) chain E residue 42 type sequence P description binding site for residue COA E 301 source : AE1 86) chain E residue 62 type sequence Y description binding site for residue COA E 301 source : AE1 87) chain E residue 95 type sequence N description binding site for residue COA E 301 source : AE1 88) chain E residue 97 type sequence F description binding site for residue COA E 301 source : AE1 89) chain E residue 159 type sequence A description binding site for residue COA E 301 source : AE1 90) chain E residue 163 type sequence T description binding site for residue COA E 301 source : AE1 91) chain E residue 165 type sequence T description binding site for residue COA E 301 source : AE1 92) chain F residue 66 type sequence Q description binding site for residue COA E 301 source : AE1 93) chain F residue 93 type sequence R description binding site for residue COA E 301 source : AE1 94) chain E residue 131 type sequence D description binding site for residue SO4 E 302 source : AE2 95) chain E residue 132 type sequence H description binding site for residue SO4 E 302 source : AE2 96) chain E residue 8 type sequence R description binding site for residue SO4 E 303 source : AE3 97) chain E residue 78 type sequence R description binding site for residue SO4 E 304 source : AE4 98) chain E residue 196 type sequence W description binding site for residue SO4 E 304 source : AE4 99) chain E residue 66 type sequence Q description binding site for residue COA F 301 source : AE5 100) chain E residue 93 type sequence R description binding site for residue COA F 301 source : AE5 101) chain F residue 29 type sequence H description binding site for residue COA F 301 source : AE5 102) chain F residue 30 type sequence A description binding site for residue COA F 301 source : AE5 103) chain F residue 31 type sequence A description binding site for residue COA F 301 source : AE5 104) chain F residue 32 type sequence L description binding site for residue COA F 301 source : AE5 105) chain F residue 33 type sequence R description binding site for residue COA F 301 source : AE5 106) chain F residue 42 type sequence P description binding site for residue COA F 301 source : AE5 107) chain F residue 95 type sequence N description binding site for residue COA F 301 source : AE5 108) chain F residue 96 type sequence G description binding site for residue COA F 301 source : AE5 109) chain F residue 97 type sequence F description binding site for residue COA F 301 source : AE5 110) chain F residue 160 type sequence P description binding site for residue COA F 301 source : AE5 111) chain F residue 163 type sequence T description binding site for residue COA F 301 source : AE5 112) chain F residue 130 type sequence A description binding site for residue SO4 F 302 source : AE6 113) chain F residue 131 type sequence D description binding site for residue SO4 F 302 source : AE6 114) chain F residue 197 type sequence R description binding site for residue SO4 F 303 source : AE7 115) chain F residue 8 type sequence R description binding site for residue SO4 F 304 source : AE8

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