eF-site ID 5hrn-A PDB Code 5hrn Chain A click to enlarge Title HIV Integrase Catalytic Domain containing F185K mutation complexed with GSK0002 Classification TRANSFERASE/INHIBITOR Compound Integrase Source Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) (POL_HV1H2) Sequence A:  SPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQE TAYFLLKLAGRWPVKTIHTDNGSNFTSATVKAACWWAGIK QEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAV QMAVFIHNKKRKGYSAGERIVDIIATDI Description Functional site 1) chain A residue 65 type sequence C description binding site for residue CAC A 301 source : AC1 2) chain A residue 92 type sequence E description binding site for residue CAC A 301 source : AC1 3) chain A residue 97 type sequence T description binding site for residue CAC A 301 source : AC1 4) chain A residue 120 type sequence N description binding site for residue CAC A 301 source : AC1 5) chain A residue 130 type sequence C description binding site for residue CAC A 302 source : AC2 6) chain A residue 135 type sequence I description binding site for residue CAC A 302 source : AC2 7) chain A residue 136 type sequence K description binding site for residue CAC A 302 source : AC2 8) chain A residue 137 type sequence Q description binding site for residue CAC A 302 source : AC2 9) chain A residue 71 type sequence K description binding site for residue SO4 A 303 source : AC3 10) chain A residue 170 type sequence E description binding site for residue SO4 A 303 source : AC3 11) chain A residue 171 type sequence H description binding site for residue SO4 A 303 source : AC3 12) chain A residue 172 type sequence L description binding site for residue SO4 A 303 source : AC3 13) chain A residue 105 type sequence A description binding site for residue EDO A 304 source : AC4 14) chain A residue 106 type sequence G description binding site for residue EDO A 304 source : AC4 15) chain A residue 108 type sequence W description binding site for residue EDO A 304 source : AC4 16) chain A residue 109 type sequence P description binding site for residue EDO A 304 source : AC4 17) chain A residue 184 type sequence N description binding site for residue EDO A 304 source : AC4 18) chain A residue 185 type sequence K description binding site for residue EDO A 304 source : AC4 19) chain A residue 197 type sequence G description binding site for residue EDO A 304 source : AC4 20) chain A residue 69 type sequence E description binding site for residue EDO A 305 source : AC5 21) chain A residue 163 type sequence G description binding site for residue EDO A 305 source : AC5 22) chain A residue 102 type sequence L description binding site for residue 65P A 306 source : AC6 23) chain A residue 125 type sequence T description binding site for residue 65P A 306 source : AC6 24) chain A residue 129 type sequence A description binding site for residue 65P A 306 source : AC6 25) chain A residue 132 type sequence W description binding site for residue 65P A 306 source : AC6 26) chain A residue 168 type sequence Q description binding site for residue 65P A 306 source : AC6 27) chain A residue 169 type sequence A description binding site for residue 65P A 306 source : AC6 28) chain A residue 170 type sequence E description binding site for residue 65P A 306 source : AC6 29) chain A residue 171 type sequence H description binding site for residue 65P A 306 source : AC6 30) chain A residue 174 type sequence T description binding site for residue 65P A 306 source : AC6 31) chain A residue 64 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 32) chain A residue 116 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 33) chain A residue 152 type BINDING sequence E description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI2

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