|
|
eF-site ID
|
5hbh-B |
|
PDB Code
|
5hbh |
|
Chain
|
B |
|
click to enlarge
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Title
|
CDK8-CYCC IN COMPLEX WITH 5-{5-Chloro-4-[1-(2-methoxy-ethyl)-1,8-diaza-spiro[4.5]dec-8-yl]-pyridin-3-yl}-1-methyl-1,3-dihydro-benzo[c]isothiazole 2,2-dioxide |
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Classification
|
TRANSFERASE |
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Compound
|
Cyclin-dependent kinase 8 |
|
Source
|
Homo sapiens (Human) (CCNC_HUMAN) |
|
|
Sequence
|
B: |
DDDDKAMAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSE
EEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYA
RYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATS
VLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYH
PYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPP
FMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVI
LKLYEQWKNFDERKEMATILSKMPKPKPPP
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
248 |
| type |
|
| sequence |
K
|
| description |
binding site for residue FMT A 403
|
| source |
: AC3
|
|
|
2)
|
chain |
B |
| residue |
203 |
| type |
|
| sequence |
H
|
| description |
binding site for residue FMT B 301
|
| source |
: AC4
|
|
|
3)
|
chain |
B |
| residue |
211 |
| type |
|
| sequence |
K
|
| description |
binding site for residue FMT B 301
|
| source |
: AC4
|
|
|
4)
|
chain |
B |
| residue |
213 |
| type |
|
| sequence |
A
|
| description |
binding site for residue FMT B 301
|
| source |
: AC4
|
|
|
5)
|
chain |
B |
| residue |
0 |
| type |
|
| sequence |
A
|
| description |
binding site for residue FMT B 302
|
| source |
: AC5
|
|
|
6)
|
chain |
B |
| residue |
152 |
| type |
|
| sequence |
V
|
| description |
binding site for residue FMT B 302
|
| source |
: AC5
|
|
|
7)
|
chain |
B |
| residue |
157 |
| type |
|
| sequence |
R
|
| description |
binding site for residue FMT B 302
|
| source |
: AC5
|
|
|
|