eF-site ID 5hbh-A PDB Code 5hbh Chain A click to enlarge Title CDK8-CYCC IN COMPLEX WITH 5-{5-Chloro-4-[1-(2-methoxy-ethyl)-1,8-diaza-spiro[4.5]dec-8-yl]-pyridin-3-yl}-1-methyl-1,3-dihydro-benzo[c]isothiazole 2,2-dioxide Classification TRANSFERASE Compound Cyclin-dependent kinase 8 Source null (CCNC_HUMAN) Sequence A:  DKMDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKA KRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNV ISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASQLPR GMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPE RGRVKIADMGFARLVVTFWYRAPELLLGARHYTKAIDIWA IGCIFAELLTSEPIFHCRQEPYHHDQLDRIFNVMGFPADK DWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPD SKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDV FAGCQIPYPKREFLTE Description (1)  Cyclin-dependent kinase 8 (E.C.2.7.11.22,2.7.11.23), Cyclin-C Functional site 1) chain A residue 27 type sequence V description binding site for residue 5Y7 A 401 source : AC1 2) chain A residue 32 type sequence Y description binding site for residue 5Y7 A 401 source : AC1 3) chain A residue 35 type sequence V description binding site for residue 5Y7 A 401 source : AC1 4) chain A residue 50 type sequence A description binding site for residue 5Y7 A 401 source : AC1 5) chain A residue 52 type sequence K description binding site for residue 5Y7 A 401 source : AC1 6) chain A residue 97 type sequence F description binding site for residue 5Y7 A 401 source : AC1 7) chain A residue 98 type sequence D description binding site for residue 5Y7 A 401 source : AC1 8) chain A residue 100 type sequence A description binding site for residue 5Y7 A 401 source : AC1 9) chain A residue 103 type sequence D description binding site for residue 5Y7 A 401 source : AC1 10) chain A residue 106 type sequence H description binding site for residue 5Y7 A 401 source : AC1 11) chain A residue 155 type sequence A description binding site for residue 5Y7 A 401 source : AC1 12) chain A residue 158 type sequence L description binding site for residue 5Y7 A 401 source : AC1 13) chain A residue 173 type sequence D description binding site for residue 5Y7 A 401 source : AC1 14) chain A residue 176 type sequence F description binding site for residue 5Y7 A 401 source : AC1 15) chain A residue 356 type sequence R description binding site for residue 5Y7 A 401 source : AC1 16) chain A residue 150 type sequence R description binding site for residue EDO A 402 source : AC2 17) chain A residue 151 type sequence D description binding site for residue EDO A 402 source : AC2 18) chain A residue 200 type sequence R description binding site for residue EDO A 402 source : AC2 19) chain A residue 211 type sequence Y description binding site for residue EDO A 402 source : AC2 20) chain A residue 259 type sequence M description binding site for residue FMT A 403 source : AC3 21) chain A residue 313 type sequence Q description binding site for residue FMT A 403 source : AC3 22) chain A residue 316 type sequence L description binding site for residue FMT A 403 source : AC3 23) chain A residue 27-52 type prosite sequence VGRGTYGHVYKAKRKDGKDDKDYALK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGTYGHVYkAkrkdgkddkd........YALK source prosite : PS00107 24) chain A residue 147-159 type prosite sequence VLHRDLKPANILV description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpaNILV source prosite : PS00108 25) chain A residue 151 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 26) chain A residue 52 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 27) chain A residue 27 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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