eF-site ID 5hbe-B PDB Code 5hbe Chain B click to enlarge Title CDK8-CYCC IN COMPLEX WITH 8-[3-Chloro-5-(1-methyl-2,2-dioxo-2, 3-dihydro-1H-2l6-benzo[c]isothiazol-5-yl)-pyridin- 4-yl]-1-oxa-3,8-diaza-spiro[4.5]decan-2-one Classification TRANSFERASE Compound Cyclin-dependent kinase 8 Source Homo sapiens (Human) (CCNC_HUMAN) Sequence B:  KAMAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYW KLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSL KSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKT RFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRP LLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIA LACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLY EQWKNFDERKEMATILSKMPKPKPPP Description (1)  Cyclin-dependent kinase 8 (E.C.2.7.11.22,2.7.11.23), Cyclin-C Functional site 1) chain B residue 49 type sequence Q description binding site for residue FMT B 301 source : AC5 2) chain B residue 59 type sequence Q description binding site for residue FMT B 301 source : AC5 3) chain B residue 156 type sequence Y description binding site for residue FMT B 301 source : AC5 4) chain B residue 184 type sequence Y description binding site for residue FMT B 301 source : AC5 5) chain B residue 118 type sequence T description binding site for residue FMT B 302 source : AC6 6) chain B residue 119 type sequence R description binding site for residue FMT B 302 source : AC6 7) chain B residue 120 type sequence F description binding site for residue FMT B 302 source : AC6 8) chain B residue 121 type sequence S description binding site for residue FMT B 302 source : AC6 9) chain B residue 247 type sequence R description binding site for residue FMT B 302 source : AC6 10) chain B residue 75 type sequence R description binding site for residue FMT B 303 source : AC7 11) chain B residue 147 type sequence D description binding site for residue FMT B 303 source : AC7

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