eF-site ID 5hbe-A PDB Code 5hbe Chain A click to enlarge Title CDK8-CYCC IN COMPLEX WITH 8-[3-Chloro-5-(1-methyl-2,2-dioxo-2, 3-dihydro-1H-2l6-benzo[c]isothiazol-5-yl)-pyridin- 4-yl]-1-oxa-3,8-diaza-spiro[4.5]decan-2-one Classification TRANSFERASE Compound Cyclin-dependent kinase 8 Source Homo sapiens (Human) (CCNC_HUMAN) Sequence A:  KMDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAK RKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVI SLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANQL PRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEG PERGRVKIADMGFARLFNSPLKVTFWYRAPELLLGARHYT KAIDIWAIGCIFAELLTSEPIFHCRQSNPYHHDQLDRIFN VMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYM EKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLE DPLPTSDVFAGCQIPYPKREFLTE Description Functional site 1) chain A residue 27 type sequence V description binding site for residue 5Y6 A 401 source : AC1 2) chain A residue 32 type sequence Y description binding site for residue 5Y6 A 401 source : AC1 3) chain A residue 35 type sequence V description binding site for residue 5Y6 A 401 source : AC1 4) chain A residue 50 type sequence A description binding site for residue 5Y6 A 401 source : AC1 5) chain A residue 52 type sequence K description binding site for residue 5Y6 A 401 source : AC1 6) chain A residue 98 type sequence D description binding site for residue 5Y6 A 401 source : AC1 7) chain A residue 100 type sequence A description binding site for residue 5Y6 A 401 source : AC1 8) chain A residue 103 type sequence D description binding site for residue 5Y6 A 401 source : AC1 9) chain A residue 106 type sequence H description binding site for residue 5Y6 A 401 source : AC1 10) chain A residue 155 type sequence A description binding site for residue 5Y6 A 401 source : AC1 11) chain A residue 158 type sequence L description binding site for residue 5Y6 A 401 source : AC1 12) chain A residue 173 type sequence D description binding site for residue 5Y6 A 401 source : AC1 13) chain A residue 356 type sequence R description binding site for residue 5Y6 A 401 source : AC1 14) chain A residue 52 type sequence K description binding site for residue DMS A 402 source : AC2 15) chain A residue 66 type sequence E description binding site for residue DMS A 402 source : AC2 16) chain A residue 70 type sequence L description binding site for residue DMS A 402 source : AC2 17) chain A residue 79 type sequence I description binding site for residue DMS A 402 source : AC2 18) chain A residue 97 type sequence F description binding site for residue DMS A 402 source : AC2 19) chain A residue 172 type sequence A description binding site for residue DMS A 402 source : AC2 20) chain A residue 173 type sequence D description binding site for residue DMS A 402 source : AC2 21) chain A residue 176 type sequence F description binding site for residue DMS A 402 source : AC2 22) chain A residue 75 type sequence H description binding site for residue EDO A 403 source : AC3 23) chain A residue 76 type sequence P description binding site for residue EDO A 403 source : AC3 24) chain A residue 78 type sequence V description binding site for residue EDO A 403 source : AC3 25) chain A residue 80 type sequence S description binding site for residue EDO A 403 source : AC3 26) chain A residue 170 type sequence K description binding site for residue EDO A 403 source : AC3 27) chain A residue 122 type sequence Q description binding site for residue FMT A 404 source : AC4 28) chain A residue 124 type sequence P description binding site for residue FMT A 404 source : AC4 29) chain A residue 125 type sequence R description binding site for residue FMT A 404 source : AC4 30) chain A residue 126 type sequence G description binding site for residue FMT A 404 source : AC4 31) chain A residue 128 type sequence V description binding site for residue FMT A 404 source : AC4 32) chain A residue 321 type sequence I description binding site for residue FMT B 302 source : AC6 33) chain A residue 27-52 type prosite sequence VGRGTYGHVYKAKRKDGKDDKDYALK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGTYGHVYkAkrkdgkddkd........YALK source prosite : PS00107 34) chain A residue 147-159 type prosite sequence VLHRDLKPANILV description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpaNILV source prosite : PS00108 35) chain A residue 151 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 36) chain A residue 27 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 37) chain A residue 52 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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