eF-site ID 5gwi-A PDB Code 5gwi Chain A click to enlarge Title Structure of a Human topoisomerase IIbeta fragment in complex with DNA and E7873R Classification ISOMERASE/DNA/ISOMERASE INHIBITOR Compound DNA topoisomerase 2-beta Source null (5GWI) Sequence A:  KGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGV IGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVG LQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLIN FIHHNWPSLLKHGFLEEFITKEAKEYFADMERHRILFRYA GPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLK HLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLF TCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNL AQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLS TLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLIN GAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPN YKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTW TQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVK MTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKK YETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQ ARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWK EAQEGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVND LKRKSPSDLWKEDLAAFVEELDKVESQERED Description Functional site 1) chain A residue 478 type sequence G description binding site for residue N2R A 1301 source : AC1 2) chain A residue 479 type sequence D description binding site for residue N2R A 1301 source : AC1 3) chain A residue 502 type sequence L description binding site for residue N2R A 1301 source : AC1 4) chain A residue 503 type sequence R description binding site for residue N2R A 1301 source : AC1 5) chain A residue 778 type sequence Q description binding site for residue N2R A 1301 source : AC1 6) chain A residue 782 type sequence M description binding site for residue N2R A 1301 source : AC1 7) chain A residue 478 type sequence G description binding site for residue N2N A 1302 source : AC2 8) chain A residue 479 type sequence D description binding site for residue N2N A 1302 source : AC2 9) chain A residue 502 type sequence L description binding site for residue N2N A 1302 source : AC2 10) chain A residue 503 type sequence R description binding site for residue N2N A 1302 source : AC2 11) chain A residue 778 type sequence Q description binding site for residue N2N A 1302 source : AC2 12) chain A residue 782 type sequence M description binding site for residue N2N A 1302 source : AC2 13) chain A residue 557 type sequence D description binding site for residue MG A 1303 source : AC3 14) chain A residue 559 type sequence D description binding site for residue MG A 1303 source : AC3 15) chain A residue 867 type sequence N description binding site for residue MG A 1304 source : AC4 16) chain A residue 868 type sequence G description binding site for residue MG A 1304 source : AC4 17) chain A residue 641 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 18) chain A residue 671 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 19) chain A residue 707 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 20) chain A residue 1087 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 21) chain A residue 638 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI9 22) chain A residue 475-483 type prosite sequence LTEGDSAKS description TOPOISOMERASE_II DNA topoisomerase II signature. LTEGDSAKS source prosite : PS00177 23) chain A residue 821 type ACT_SITE sequence Y description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01384, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 477 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 557 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3 26) chain A residue 559 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3 27) chain A residue 505 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 28) chain A residue 508 type SITE sequence N description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 29) chain A residue 677 type SITE sequence R description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 30) chain A residue 678 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 31) chain A residue 739 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 32) chain A residue 947 type SITE sequence W description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 33) chain A residue 773 type SITE sequence Y description Interaction with DNA => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI5 34) chain A residue 820 type SITE sequence R description Transition state stabilizer source Swiss-Prot : SWS_FT_FI6 35) chain A residue 872 type SITE sequence I description Important for DNA bending; intercalates between base pairs of target DNA source Swiss-Prot : SWS_FT_FI7

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