eF-site ID 5grm-AB PDB Code 5grm Chain A, B click to enlarge Title Crystal structure of rat STING in complex with cyclic GMP-AMP with 2'5'and 3'5'phosphodiester linkage(2'3'-cGAMP) Classification IMMUNE SYSTEM Compound Stimulator of interferon genes protein Source null (STING_RAT) Sequence A:  YFQGSHMVAHGLAWSYYIGYLKLILPGLQARIRMFNQLHN NMLSGAGSRRLYILFPLDCGVPDDLSVADPNIRFRDMLPQ QNTDRAGVKNRAYSNSVYELLENGQPAGACILEYATPLQT LFAMSQDGKAGFSREDRLEQAKLFCRTLEEILADVPESRN HCRLIVYQESEEGNSFSLSQEVLRHIRQ B:  SHMVAHGLAWSYYIGYLKLILPGLQARIRMFNQLHNNMLS GAGSRRLYILFPLDCGVPDDLSVADPNIRFRDMLPQQNTD RAGVKNRAYSNSVYELLENGQPAGACILEYATPLQTLFAM SQDGKAGFSREDRLEQAKLFCRTLEEILADVPESRNHCRL IVYQESEEGNSFSLSQEVLRHIRQEEKEEV Description Functional site 1) chain A residue 162 type sequence S description binding site for residue 1SY B 401 source : AC1 2) chain A residue 167 type sequence Y description binding site for residue 1SY B 401 source : AC1 3) chain A residue 238 type sequence R description binding site for residue 1SY B 401 source : AC1 4) chain A residue 240 type sequence Y description binding site for residue 1SY B 401 source : AC1 5) chain A residue 260 type sequence E description binding site for residue 1SY B 401 source : AC1 6) chain A residue 263 type sequence T description binding site for residue 1SY B 401 source : AC1 7) chain A residue 264 type sequence P description binding site for residue 1SY B 401 source : AC1 8) chain B residue 162 type sequence S description binding site for residue 1SY B 401 source : AC1 9) chain B residue 163 type sequence Y description binding site for residue 1SY B 401 source : AC1 10) chain B residue 167 type sequence Y description binding site for residue 1SY B 401 source : AC1 11) chain B residue 238 type sequence R description binding site for residue 1SY B 401 source : AC1 12) chain B residue 239 type sequence A description binding site for residue 1SY B 401 source : AC1 13) chain B residue 240 type sequence Y description binding site for residue 1SY B 401 source : AC1 14) chain B residue 263 type sequence T description binding site for residue 1SY B 401 source : AC1 15) chain B residue 264 type sequence P description binding site for residue 1SY B 401 source : AC1 16) chain A residue 236 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q86WV6 source Swiss-Prot : SWS_FT_FI5 17) chain B residue 236 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q86WV6 source Swiss-Prot : SWS_FT_FI5 18) chain B residue 338 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000250|UniProtKB:Q3TBT3 source Swiss-Prot : SWS_FT_FI6 19) chain A residue 241 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:Q86WV6 source Swiss-Prot : SWS_FT_FI4 20) chain B residue 241 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:Q86WV6 source Swiss-Prot : SWS_FT_FI4 21) chain A residue 162 type BINDING sequence S description BINDING => ECO:0000305|PubMed:26669264 source Swiss-Prot : SWS_FT_FI1 22) chain B residue 162 type BINDING sequence S description BINDING => ECO:0000305|PubMed:26669264 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 263 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:Q3TBT3 source Swiss-Prot : SWS_FT_FI2 24) chain B residue 166 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:Q3TBT3 source Swiss-Prot : SWS_FT_FI2 25) chain B residue 263 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:Q3TBT3 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 166 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:Q3TBT3 source Swiss-Prot : SWS_FT_FI2 27) chain B residue 167 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:Q86WV6 source Swiss-Prot : SWS_FT_FI3 28) chain B residue 238 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:Q86WV6 source Swiss-Prot : SWS_FT_FI3 29) chain A residue 167 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:Q86WV6 source Swiss-Prot : SWS_FT_FI3 30) chain A residue 238 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:Q86WV6 source Swiss-Prot : SWS_FT_FI3

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