eF-site ID 5fxi-ABCD
PDB Code 5fxi
Chain A, B, C, D
Title GluN1b-GluN2B NMDA receptor structure in non-active-2 conformation
Classification TRANSPORT PROTEIN
Compound N-METHYL-D-ASPARTATE RECEPTOR GLUN1
Source (NMDE2_RAT)
Sequence A:  KIVNIGAVLSTRKHEQMFREAVNQANKRIQLQATSVTHKP
NAIQMALSVCEDLISSQVYAILVSHPPHFTPTPVSYTAGF
YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFE
MMRVYNWNHIILLVSDDHEGRAAQKRLETLLEERESKGPK
AEKVLQFDPGTKNVTALLMEARELEARVIILSASEDDAAT
VYRAAAMLDMTGSGYVWLVGEREISGNALRYAPDGIIGLQ
LINGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCVG
NTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFAQ
YSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPR
GYQMSTRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGDP
VKKVICTGPNDTVPQCCYGFCIDLLIKLARTMQFTYEVHL
VADGKFGTQERVQNSNKKEWNGMMGELLSGQADMIVAPLT
INNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPF
QSTLWLLVGLSVHVVAVMLYLLDRFSLTLSSAMWFSWGVL
LNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAF
LVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFR
RQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSA
VLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQQVSL
SILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTCENMA
GVFMLVAGGIVAGIFLIFIEIAYK
B:  PPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVELV
AMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQI
LDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIE
QQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIE
NSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLY
CTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPS
EFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSEH
SFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRDLSF
SEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVW
PRMCDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKR
GYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKI
NGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFI
ETGISVMVSRSNSPSAFLEPFSACVWVMMFVMLLIVSAVA
VFVFEYFSPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSK
IMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDK
KFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKF
NQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLV
TIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEM
EELEALWLTGICHNEKMSSQLDIDNMAGVFYMLGAAMALS
LITFISEHLF
C:  KIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLQATS
VTHKPNAIQMALSVCEDLISSQVYAILVSHTPTPVSYTAG
FYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWF
EMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEERESKGP
KAEKVLQFDPGTKNVTALLMEARELEARVIILSASEDDAA
TVYRAAAMLDMTGSGYVWLVGEREISGNALRYAPDGIIGL
QLINGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCV
GNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFA
QYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKP
RGYQMSTRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGD
PVKKVICTGPNDGSPRHTVPQCCYGFCIDLLIKLARTMQF
TYEVHLVADGKFGTQERVQNSNKKEWNGMMGELLSGQADM
IVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLD
SFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSTLSSAMWF
SWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTA
NLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSV
DIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAF
IWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWK
QQVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLT
CENMAGVFMLVAGGIVAGIFLIFIEIA
D:  PPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVELV
AMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQI
LDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIE
QQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIE
NSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLY
CTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPS
EFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSEH
SFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRDLSF
SEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVW
PRMCDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKR
YIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKIN
GTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIE
TGISVMVSRSNSPSAFLEPFSACVWVMMFVMLLIVSAVAV
FVFEFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVW
AFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPN
DFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVD
DALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGK
VFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEAL
WLTGICHNEKMSSQLDIDNMAGVFYMLGAAMALSLITFIS
EHLF
Description


Functional site
1) chain B
residue 647-817
type TOPO_DOM
sequence TANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTV
PNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLSLKTGKL
DAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAI
QKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKM
SSQLDIDN
description Extracellular => ECO:0000269|PubMed:24876489
source Swiss-Prot : SWS_FT_FI1
2) chain D
residue 647-817
type TOPO_DOM
sequence TANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTV
PNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLSLKTGKL
DAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAI
QKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKM
SSQLDIDN
description Extracellular => ECO:0000269|PubMed:24876489
source Swiss-Prot : SWS_FT_FI1
3) chain C
residue 652-668
type TOPO_DOM
sequence ILGMVWAGFAMIIVASY
description Extracellular => ECO:0000269|PubMed:24876489
source Swiss-Prot : SWS_FT_FI1
4) chain C
residue 834-854
type TOPO_DOM
sequence MAGVFMLVAGGIVAGIFLIFI
description Extracellular => ECO:0000269|PubMed:24876489
source Swiss-Prot : SWS_FT_FI1
5) chain B
residue 341
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19910922, ECO:0000269|PubMed:24876489, ECO:0007744|PDB:3JPW, ECO:0007744|PDB:3JPY, ECO:0007744|PDB:3QEL, ECO:0007744|PDB:3QEM, ECO:0007744|PDB:4PE5, ECO:0007744|PDB:5TPZ
source Swiss-Prot : SWS_FT_FI10
6) chain D
residue 341
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19910922, ECO:0000269|PubMed:24876489, ECO:0007744|PDB:3JPW, ECO:0007744|PDB:3JPY, ECO:0007744|PDB:3QEL, ECO:0007744|PDB:3QEM, ECO:0007744|PDB:4PE5, ECO:0007744|PDB:5TPZ
source Swiss-Prot : SWS_FT_FI10
7) chain B
residue 348
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI11
8) chain B
residue 491
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI11
9) chain B
residue 542
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI11
10) chain D
residue 348
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI11
11) chain D
residue 491
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI11
12) chain D
residue 542
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI11
13) chain B
residue 688
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI12
14) chain D
residue 688
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI12
15) chain A
residue 492
type CARBOHYD
sequence Q
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI13
16) chain A
residue 512
type CARBOHYD
sequence Q
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI13
17) chain A
residue 695
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI13
18) chain C
residue 492
type CARBOHYD
sequence Q
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI13
19) chain C
residue 512
type CARBOHYD
sequence Q
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI13
20) chain C
residue 695
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI13
21) chain B
residue 558-576
type TRANSMEM
sequence VWVMMFVMLLIVSAVAVFV
description Helical => ECO:0000269|PubMed:24876489
source Swiss-Prot : SWS_FT_FI2
22) chain B
residue 631-646
type TRANSMEM
sequence MVSVWAFFAVIFLASY
description Helical => ECO:0000269|PubMed:24876489
source Swiss-Prot : SWS_FT_FI2
23) chain B
residue 818-837
type TRANSMEM
sequence MAGVFYMLGAAMALSLITFI
description Helical => ECO:0000269|PubMed:24876489
source Swiss-Prot : SWS_FT_FI2
24) chain D
residue 558-576
type TRANSMEM
sequence VWVMMFVMLLIVSAVAVFV
description Helical => ECO:0000269|PubMed:24876489
source Swiss-Prot : SWS_FT_FI2
25) chain D
residue 631-646
type TRANSMEM
sequence MVSVWAFFAVIFLASY
description Helical => ECO:0000269|PubMed:24876489
source Swiss-Prot : SWS_FT_FI2
26) chain D
residue 818-837
type TRANSMEM
sequence MAGVFYMLGAAMALSLITFI
description Helical => ECO:0000269|PubMed:24876489
source Swiss-Prot : SWS_FT_FI2
27) chain B
residue 577-603
type TOPO_DOM
sequence FEYFSPSFTIG
description Cytoplasmic => ECO:0000269|PubMed:24876489
source Swiss-Prot : SWS_FT_FI3
28) chain B
residue 624-630
type TOPO_DOM
sequence KGTTSKI
description Cytoplasmic => ECO:0000269|PubMed:24876489
source Swiss-Prot : SWS_FT_FI3
29) chain D
residue 577-603
type TOPO_DOM
sequence FEFTIG
description Cytoplasmic => ECO:0000269|PubMed:24876489
source Swiss-Prot : SWS_FT_FI3
30) chain D
residue 624-630
type TOPO_DOM
sequence KGTTSKI
description Cytoplasmic => ECO:0000269|PubMed:24876489
source Swiss-Prot : SWS_FT_FI3
31) chain B
residue 604-623
type INTRAMEM
sequence KAIWLLWGLVFNNSVPVQNP
description Discontinuously helical => ECO:0000305|PubMed:24876489
source Swiss-Prot : SWS_FT_FI4
32) chain D
residue 604-623
type INTRAMEM
sequence KAIWLLWGLVFNNSVPVQNP
description Discontinuously helical => ECO:0000305|PubMed:24876489
source Swiss-Prot : SWS_FT_FI4
33) chain B
residue 127
type BINDING
sequence H
description BINDING => ECO:0000305|PubMed:19910922, ECO:0007744|PDB:3JPY
source Swiss-Prot : SWS_FT_FI5
34) chain B
residue 284
type BINDING
sequence E
description BINDING => ECO:0000305|PubMed:19910922, ECO:0007744|PDB:3JPY
source Swiss-Prot : SWS_FT_FI5
35) chain D
residue 127
type BINDING
sequence H
description BINDING => ECO:0000305|PubMed:19910922, ECO:0007744|PDB:3JPY
source Swiss-Prot : SWS_FT_FI5
36) chain D
residue 284
type BINDING
sequence E
description BINDING => ECO:0000305|PubMed:19910922, ECO:0007744|PDB:3JPY
source Swiss-Prot : SWS_FT_FI5
37) chain B
residue 514
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI6
38) chain B
residue 519
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI6
39) chain B
residue 732
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI6
40) chain D
residue 514
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI6
41) chain D
residue 519
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI6
42) chain D
residue 732
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI6
43) chain B
residue 690
type BINDING
sequence S
description BINDING => ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI7
44) chain D
residue 690
type BINDING
sequence S
description BINDING => ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI7
45) chain C
residue 61
type BINDING
sequence Q
description BINDING => ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI7
46) chain C
residue 260
type BINDING
sequence D
description BINDING => ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI7
47) chain B
residue 615
type SITE
sequence N
description Functional determinant of NMDA receptors => ECO:0000250
source Swiss-Prot : SWS_FT_FI8
48) chain D
residue 615
type SITE
sequence N
description Functional determinant of NMDA receptors => ECO:0000250
source Swiss-Prot : SWS_FT_FI8
49) chain C
residue 224
type SITE
sequence N
description Functional determinant of NMDA receptors => ECO:0000250
source Swiss-Prot : SWS_FT_FI8
50) chain C
residue 389
type SITE
sequence N
description Functional determinant of NMDA receptors => ECO:0000250
source Swiss-Prot : SWS_FT_FI8
51) chain B
residue 74
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19910922, ECO:0000269|PubMed:24876489, ECO:0007744|PDB:3JPW, ECO:0007744|PDB:3JPY, ECO:0007744|PDB:3QEL, ECO:0007744|PDB:3QEM, ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI9
52) chain D
residue 74
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19910922, ECO:0000269|PubMed:24876489, ECO:0007744|PDB:3JPW, ECO:0007744|PDB:3JPY, ECO:0007744|PDB:3QEL, ECO:0007744|PDB:3QEM, ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI9

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