eF-site ID 5fxg-ABCD
PDB Code 5fxg
Chain A, B, C, D

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Title GLUN1B-GLUN2B NMDA RECEPTOR IN ACTIVE CONFORMATION
Classification TRANSPORT PROTEIN
Compound N-METHYL-D-ASPARTATE RECEPTOR GLUN1
Source (NMDE2_RAT)
Sequence A:  KIVNIGAVLSTRKHEQMFREAVNQANKRIQLQATSVTHKP
NAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSY
TAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSS
VWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEERES
NKRGPKAEKVLQFDPGTKNVTALLMEARELEARVIILSAS
EDDAATVYRAAAMLDMTGSGYVWLVGEREISGNALRYAPD
GIIGLQLINGKNESAHISDAVGVVAQAVHELLEKENITDP
PRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDG
DRKFAQYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGG
ETEKPRGYQMSTRLKIVTIHQEPFVYVKPTMSDGTCKEEF
TVNGDPVKKVICTGPNDTVPQCCYGFCIDLLIKLARTMQF
TYEVHLVADGKFGTQERVQNSNKKEWNGMMGELLSGQADM
IVAPLTINNERAQYIEFSKPFKYQGLTILVKKRITGINDP
RLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHN
YESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTG
ELFFRSGFGIGMRKDSPWKQQVSLSILKSHENGFMEDLDK
TWVRYQEC
B:  PPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVELV
AMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQI
LDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIE
QQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIE
NSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLY
CTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPS
EFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSEH
SFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRDLSF
SEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVW
PRMCDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKR
YIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKIN
GTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIE
TGISVMVSREYVDQVSGLSDKKFQRPNDFSPPFRFGTVPN
GSTERNIRNNYAEMHAYMGKFNQRGVDDALLSLKTGKLDA
FIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQK
DSGWKRQVDLAILQLFGDGEMEELEALWLTGICH
C:  KIVNIGAVLSTRKHEQMFREAVNQANKRIQLQATSVTHKP
NAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSY
TAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSS
VWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEERES
NKRGPKAEKVLQFDPGTKNVTALLMEARELEARVIILSAS
EDDAATVYRAAAMLDMTGSGYVWLVGEREISGNALRYAPD
GIIGLQLINGKNESAHISDAVGVVAQAVHELLEKENITDP
PRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDG
DRKFAQYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGG
ETEKPRGYQMSTRLKIVTIHQEPFVYVKPTMSDGTCKEEF
TVNGDPVKKVICTGPNDTVPQCCYGFCIDLLIKLARTMQF
TYEVHLVADGKFGTQERVQNSNKKEWNGMMGELLSGQADM
IVAPLTINNERAQYIEFSKPFKYQGLTILVKKRITGINDP
RLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHN
YESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTG
ELFFRSGFGIGMRKDSPWKQQVSLSILKSHENGFMEDLDK
TWVRYQEC
D:  PPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVELV
AMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQI
LDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIE
QQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIE
NSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLY
CTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPS
EFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSEH
SFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRDLSF
SEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVW
PRMCDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKR
YIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKIN
GTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIE
TGISVMVSREYVDQVSGLSDKKFQRPNDFSPPFRFGTVPN
GSTERNIRNNYAEMHAYMGKFNQRGVDDALLSLKTGKLDA
FIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQK
DSGWKRQVDLAILQLFGDGEMEELEALWLTGICH
Description (1)  N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B


Functional site
1) chain A
residue 492
type CARBOHYD
sequence Q
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI13
2) chain A
residue 512
type CARBOHYD
sequence Q
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI13
3) chain A
residue 695
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI13
4) chain C
residue 471
type CARBOHYD
sequence T
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI13
5) chain C
residue 491
type CARBOHYD
sequence M
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI13
6) chain B
residue 341
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19910922, ECO:0000269|PubMed:24876489, ECO:0007744|PDB:3JPW, ECO:0007744|PDB:3JPY, ECO:0007744|PDB:3QEL, ECO:0007744|PDB:3QEM, ECO:0007744|PDB:4PE5, ECO:0007744|PDB:5TPZ
source Swiss-Prot : SWS_FT_FI10
7) chain D
residue 341
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19910922, ECO:0000269|PubMed:24876489, ECO:0007744|PDB:3JPW, ECO:0007744|PDB:3JPY, ECO:0007744|PDB:3QEL, ECO:0007744|PDB:3QEM, ECO:0007744|PDB:4PE5, ECO:0007744|PDB:5TPZ
source Swiss-Prot : SWS_FT_FI10
8) chain B
residue 348
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI11
9) chain B
residue 491
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI11
10) chain D
residue 348
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI11
11) chain D
residue 491
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI11
12) chain B
residue 688
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI12
13) chain D
residue 688
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI12
14) chain B
residue 690
type BINDING
sequence S
description BINDING => ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI7
15) chain D
residue 690
type BINDING
sequence S
description BINDING => ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI7
16) chain C
residue 61
type BINDING
sequence Q
description BINDING => ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI7
17) chain C
residue 239
type BINDING
sequence V
description BINDING => ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI7
18) chain C
residue 368
type SITE
sequence K
description Functional determinant of NMDA receptors => ECO:0000250
source Swiss-Prot : SWS_FT_FI8
19) chain B
residue 74
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19910922, ECO:0000269|PubMed:24876489, ECO:0007744|PDB:3JPW, ECO:0007744|PDB:3JPY, ECO:0007744|PDB:3QEL, ECO:0007744|PDB:3QEM, ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI9
20) chain D
residue 74
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19910922, ECO:0000269|PubMed:24876489, ECO:0007744|PDB:3JPW, ECO:0007744|PDB:3JPY, ECO:0007744|PDB:3QEL, ECO:0007744|PDB:3QEM, ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI9
21) chain B
residue 127
type BINDING
sequence H
description BINDING => ECO:0000305|PubMed:19910922, ECO:0007744|PDB:3JPY
source Swiss-Prot : SWS_FT_FI5
22) chain B
residue 284
type BINDING
sequence E
description BINDING => ECO:0000305|PubMed:19910922, ECO:0007744|PDB:3JPY
source Swiss-Prot : SWS_FT_FI5
23) chain D
residue 127
type BINDING
sequence H
description BINDING => ECO:0000305|PubMed:19910922, ECO:0007744|PDB:3JPY
source Swiss-Prot : SWS_FT_FI5
24) chain D
residue 284
type BINDING
sequence E
description BINDING => ECO:0000305|PubMed:19910922, ECO:0007744|PDB:3JPY
source Swiss-Prot : SWS_FT_FI5
25) chain B
residue 514
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI6
26) chain B
residue 519
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI6
27) chain B
residue 732
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI6
28) chain D
residue 514
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI6
29) chain D
residue 519
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI6
30) chain D
residue 732
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5
source Swiss-Prot : SWS_FT_FI6

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