eF-site ID 5fvz-B PDB Code 5fvz Chain B click to enlarge Title Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-(2-(5-(3-(dimethylamino)propyl)pyridin-3-yl)ethyl)-4-methylpyridin-2-amine Classification OXIDOREDUCTASE Compound ENDOTHELIAL NITRIC OXIDE SYNTHASE Source Bos taurus (Bovine) (NOS3_BOVIN) Sequence B:  KFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLP RKAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEV ASTGTYHLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFD ARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPG RGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQH GWTPGNGRFDVLPLLLQAPDEAPELFVLPPELVLEVPLEH PTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWY MSTEIGTRNLCDPHRYNILEDVAVXMDLDTRTTSSLWKDK AAVEINLAVLHSFQLAKVTIVDHHAATVSFMKHLDNEQKA RGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQP DPW Description (1)  ENDOTHELIAL NITRIC OXIDE SYNTHASE (E.C.1.14.13.39) Functional site 1) chain B residue 447 type sequence W description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 2) chain B residue 462 type sequence F description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 3) chain B residue 463 type sequence H description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 4) chain B residue 464 type sequence Q description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 5) chain B residue 180 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 6) chain B residue 186 type sequence C description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 7) chain B residue 228 type sequence S description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 8) chain B residue 355 type sequence F description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 9) chain B residue 356 type sequence S description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 10) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 11) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 12) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 13) chain B residue 477 type sequence Y description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 14) chain B residue 104 type sequence S description BINDING SITE FOR RESIDUE H4B B 600 source : AC7 15) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE H4B B 600 source : AC7 16) chain B residue 448 type sequence A description BINDING SITE FOR RESIDUE H4B B 600 source : AC7 17) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE H4B B 600 source : AC7 18) chain B residue 249 type sequence Q description BINDING SITE FOR RESIDUE W67 B 800 source : AC8 19) chain B residue 357 type sequence G description BINDING SITE FOR RESIDUE W67 B 800 source : AC8 20) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE W67 B 800 source : AC8 21) chain B residue 359 type sequence Y description BINDING SITE FOR RESIDUE W67 B 800 source : AC8 22) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE W67 B 800 source : AC8 23) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE W67 B 800 source : AC8 24) chain B residue 477 type sequence Y description BINDING SITE FOR RESIDUE W67 B 800 source : AC8 25) chain B residue 106 type sequence V description BINDING SITE FOR RESIDUE GOL B 880 source : AC9 26) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE GOL B 880 source : AC9 27) chain B residue 373 type sequence H description BINDING SITE FOR RESIDUE GOL B 880 source : AC9 28) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE GOL B 880 source : AC9 29) chain B residue 249 type sequence Q description BINDING SITE FOR RESIDUE CL B 901 source : BC1 30) chain B residue 359 type sequence Y description BINDING SITE FOR RESIDUE CL B 901 source : BC1 31) chain B residue 368 type sequence N description BINDING SITE FOR RESIDUE CL B 901 source : BC1 32) chain B residue 96 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : BC2 33) chain B residue 101 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : BC2 34) chain B residue 104 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 35) chain B residue 249 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 36) chain B residue 358 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 37) chain B residue 359 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 38) chain B residue 363 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 39) chain B residue 368 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 40) chain B residue 448 type BINDING sequence A description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 41) chain B residue 449 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 42) chain B residue 462 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 43) chain B residue 477 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 44) chain B residue 186 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI3 45) chain B residue 96 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 46) chain B residue 101 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1

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