eF-site ID 5fvx-AB PDB Code 5fvx Chain A, B click to enlarge Title Structure of human nNOS R354A G357D mutant heme domain in complex with with 6-(2-(5-(3-(DIMETHYLAMINO)PROPYL) PYRIDIN-3-YL)ETHYL)-4-METHYLPYRIDIN-2-AMINE Classification OXIDOREDUCTASE Compound NITRIC OXIDE SYNTHASE, BRAIN Source Homo sapiens (Human) (NOS1_HUMAN) Sequence A:  CPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIM HPDVATKDQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEV NKEIDTTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKL QVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQ RTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEI CIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEV PIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPF SGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSL WKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMEN EYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSF EYQPDPWNTHVWK B:  RFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHP SATKDQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKE IDTTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVF DARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTD GKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQ QGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIR HPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGW YMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKD QALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYR CRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQ PDPWNTHVWK Description (1)  NITRIC OXIDE SYNTHASE, BRAIN Functional site 1) chain A residue 414 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 2) chain A residue 420 type sequence C description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 3) chain A residue 589 type sequence F description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 4) chain A residue 590 type sequence S description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 5) chain A residue 592 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 6) chain A residue 597 type sequence E description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 7) chain A residue 683 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 8) chain A residue 709 type sequence F description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 9) chain A residue 711 type sequence Y description BINDING SITE FOR RESIDUE HEM A 750 source : AC1 10) chain A residue 339 type sequence S description BINDING SITE FOR RESIDUE H4B A 760 source : AC2 11) chain A residue 601 type sequence R description BINDING SITE FOR RESIDUE H4B A 760 source : AC2 12) chain A residue 682 type sequence V description BINDING SITE FOR RESIDUE H4B A 760 source : AC2 13) chain A residue 683 type sequence W description BINDING SITE FOR RESIDUE H4B A 760 source : AC2 14) chain B residue 681 type sequence W description BINDING SITE FOR RESIDUE H4B A 760 source : AC2 15) chain B residue 696 type sequence F description BINDING SITE FOR RESIDUE H4B A 760 source : AC2 16) chain B residue 697 type sequence H description BINDING SITE FOR RESIDUE H4B A 760 source : AC2 17) chain B residue 698 type sequence Q description BINDING SITE FOR RESIDUE H4B A 760 source : AC2 18) chain B residue 699 type sequence E description BINDING SITE FOR RESIDUE H4B A 760 source : AC2 19) chain A residue 483 type sequence Q description BINDING SITE FOR RESIDUE W67 A 800 source : AC3 20) chain A residue 486 type sequence R description BINDING SITE FOR RESIDUE W67 A 800 source : AC3 21) chain A residue 567 type sequence Y description BINDING SITE FOR RESIDUE W67 A 800 source : AC3 22) chain A residue 591 type sequence G description BINDING SITE FOR RESIDUE W67 A 800 source : AC3 23) chain A residue 592 type sequence W description BINDING SITE FOR RESIDUE W67 A 800 source : AC3 24) chain A residue 593 type sequence Y description BINDING SITE FOR RESIDUE W67 A 800 source : AC3 25) chain A residue 597 type sequence E description BINDING SITE FOR RESIDUE W67 A 800 source : AC3 26) chain A residue 331 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC4 27) chain A residue 336 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC4 28) chain B residue 331 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC4 29) chain B residue 336 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC4 30) chain B residue 414 type sequence W description BINDING SITE FOR RESIDUE HEM B 750 source : AC5 31) chain B residue 420 type sequence C description BINDING SITE FOR RESIDUE HEM B 750 source : AC5 32) chain B residue 462 type sequence S description BINDING SITE FOR RESIDUE HEM B 750 source : AC5 33) chain B residue 589 type sequence F description BINDING SITE FOR RESIDUE HEM B 750 source : AC5 34) chain B residue 590 type sequence S description BINDING SITE FOR RESIDUE HEM B 750 source : AC5 35) chain B residue 592 type sequence W description BINDING SITE FOR RESIDUE HEM B 750 source : AC5 36) chain B residue 597 type sequence E description BINDING SITE FOR RESIDUE HEM B 750 source : AC5 37) chain B residue 683 type sequence W description BINDING SITE FOR RESIDUE HEM B 750 source : AC5 38) chain B residue 709 type sequence F description BINDING SITE FOR RESIDUE HEM B 750 source : AC5 39) chain B residue 711 type sequence Y description BINDING SITE FOR RESIDUE HEM B 750 source : AC5 40) chain A residue 681 type sequence W description BINDING SITE FOR RESIDUE H4B B 760 source : AC6 41) chain A residue 696 type sequence F description BINDING SITE FOR RESIDUE H4B B 760 source : AC6 42) chain A residue 697 type sequence H description BINDING SITE FOR RESIDUE H4B B 760 source : AC6 43) chain A residue 698 type sequence Q description BINDING SITE FOR RESIDUE H4B B 760 source : AC6 44) chain B residue 339 type sequence S description BINDING SITE FOR RESIDUE H4B B 760 source : AC6 45) chain B residue 341 type sequence M description BINDING SITE FOR RESIDUE H4B B 760 source : AC6 46) chain B residue 601 type sequence R description BINDING SITE FOR RESIDUE H4B B 760 source : AC6 47) chain B residue 682 type sequence V description BINDING SITE FOR RESIDUE H4B B 760 source : AC6 48) chain B residue 683 type sequence W description BINDING SITE FOR RESIDUE H4B B 760 source : AC6 49) chain B residue 483 type sequence Q description BINDING SITE FOR RESIDUE W67 B 800 source : AC7 50) chain B residue 486 type sequence R description BINDING SITE FOR RESIDUE W67 B 800 source : AC7 51) chain B residue 567 type sequence Y description BINDING SITE FOR RESIDUE W67 B 800 source : AC7 52) chain B residue 572 type sequence V description BINDING SITE FOR RESIDUE W67 B 800 source : AC7 53) chain B residue 589 type sequence F description BINDING SITE FOR RESIDUE W67 B 800 source : AC7 54) chain B residue 592 type sequence W description BINDING SITE FOR RESIDUE W67 B 800 source : AC7 55) chain B residue 593 type sequence Y description BINDING SITE FOR RESIDUE W67 B 800 source : AC7 56) chain B residue 597 type sequence E description BINDING SITE FOR RESIDUE W67 B 800 source : AC7 57) chain A residue 420 type BINDING sequence C description axial binding residue => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N source Swiss-Prot : SWS_FT_FI2 58) chain B residue 420 type BINDING sequence C description axial binding residue => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N source Swiss-Prot : SWS_FT_FI2 59) chain A residue 419-426 type prosite sequence RCVGRIQW description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW source prosite : PS60001 60) chain B residue 339 type BINDING sequence S description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N source Swiss-Prot : SWS_FT_FI1 61) chain B residue 483 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N source Swiss-Prot : SWS_FT_FI1 62) chain B residue 592 type BINDING sequence W description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N source Swiss-Prot : SWS_FT_FI1 63) chain B residue 593 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N source Swiss-Prot : SWS_FT_FI1 64) chain B residue 597 type BINDING sequence E description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N source Swiss-Prot : SWS_FT_FI1 65) chain B residue 682 type BINDING sequence V description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N source Swiss-Prot : SWS_FT_FI1 66) chain B residue 683 type BINDING sequence W description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N source Swiss-Prot : SWS_FT_FI1 67) chain B residue 696 type BINDING sequence F description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N source Swiss-Prot : SWS_FT_FI1 68) chain B residue 711 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N source Swiss-Prot : SWS_FT_FI1 69) chain A residue 592 type BINDING sequence W description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N source Swiss-Prot : SWS_FT_FI1 70) chain A residue 593 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N source Swiss-Prot : SWS_FT_FI1 71) chain A residue 597 type BINDING sequence E description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N source Swiss-Prot : SWS_FT_FI1 72) chain A residue 682 type BINDING sequence V description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N source Swiss-Prot : SWS_FT_FI1 73) chain A residue 683 type BINDING sequence W description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N source Swiss-Prot : SWS_FT_FI1 74) chain A residue 696 type BINDING sequence F description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N source Swiss-Prot : SWS_FT_FI1 75) chain A residue 711 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N source Swiss-Prot : SWS_FT_FI1 76) chain A residue 483 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N source Swiss-Prot : SWS_FT_FI1 77) chain A residue 339 type BINDING sequence S description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N source Swiss-Prot : SWS_FT_FI1

Display surface Download Links