eF-site ID 5fvw-B
PDB Code 5fvw
Chain B

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Title Structure of human nNOS R354A G357D mutant heme domain in complex with 4-methyl-6-(2-(5-(3-(methylamino)propyl)pyridin-3-yl)ethyl) pyridin-2-amine
Classification OXIDOREDUCTASE
Compound NITRIC OXIDE SYNTHASE, BRAIN
Source Homo sapiens (Human) (NOS1_HUMAN)
Sequence B:  RFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHP
SATKDQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKE
IDTTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVF
DARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTD
GKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQ
QGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIR
HPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGW
YMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKD
QALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYR
CRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQ
PDPWNTHVWK
Description (1)  NITRIC OXIDE SYNTHASE, BRAIN


Functional site

1) chain B
residue 681
type
sequence W
description BINDING SITE FOR RESIDUE H4B A 760
source : AC2

2) chain B
residue 696
type
sequence F
description BINDING SITE FOR RESIDUE H4B A 760
source : AC2

3) chain B
residue 697
type
sequence H
description BINDING SITE FOR RESIDUE H4B A 760
source : AC2

4) chain B
residue 698
type
sequence Q
description BINDING SITE FOR RESIDUE H4B A 760
source : AC2

5) chain B
residue 699
type
sequence E
description BINDING SITE FOR RESIDUE H4B A 760
source : AC2

6) chain B
residue 331
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 900
source : AC4

7) chain B
residue 336
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 900
source : AC4

8) chain B
residue 414
type
sequence W
description BINDING SITE FOR RESIDUE HEM B 750
source : AC5

9) chain B
residue 420
type
sequence C
description BINDING SITE FOR RESIDUE HEM B 750
source : AC5

10) chain B
residue 462
type
sequence S
description BINDING SITE FOR RESIDUE HEM B 750
source : AC5

11) chain B
residue 589
type
sequence F
description BINDING SITE FOR RESIDUE HEM B 750
source : AC5

12) chain B
residue 590
type
sequence S
description BINDING SITE FOR RESIDUE HEM B 750
source : AC5

13) chain B
residue 592
type
sequence W
description BINDING SITE FOR RESIDUE HEM B 750
source : AC5

14) chain B
residue 597
type
sequence E
description BINDING SITE FOR RESIDUE HEM B 750
source : AC5

15) chain B
residue 683
type
sequence W
description BINDING SITE FOR RESIDUE HEM B 750
source : AC5

16) chain B
residue 711
type
sequence Y
description BINDING SITE FOR RESIDUE HEM B 750
source : AC5

17) chain B
residue 339
type
sequence S
description BINDING SITE FOR RESIDUE H4B B 760
source : AC6

18) chain B
residue 341
type
sequence M
description BINDING SITE FOR RESIDUE H4B B 760
source : AC6

19) chain B
residue 601
type
sequence R
description BINDING SITE FOR RESIDUE H4B B 760
source : AC6

20) chain B
residue 682
type
sequence V
description BINDING SITE FOR RESIDUE H4B B 760
source : AC6

21) chain B
residue 683
type
sequence W
description BINDING SITE FOR RESIDUE H4B B 760
source : AC6

22) chain B
residue 483
type
sequence Q
description BINDING SITE FOR RESIDUE W66 B 800
source : AC7

23) chain B
residue 486
type
sequence R
description BINDING SITE FOR RESIDUE W66 B 800
source : AC7

24) chain B
residue 567
type
sequence Y
description BINDING SITE FOR RESIDUE W66 B 800
source : AC7

25) chain B
residue 570
type
sequence P
description BINDING SITE FOR RESIDUE W66 B 800
source : AC7

26) chain B
residue 572
type
sequence V
description BINDING SITE FOR RESIDUE W66 B 800
source : AC7

27) chain B
residue 589
type
sequence F
description BINDING SITE FOR RESIDUE W66 B 800
source : AC7

28) chain B
residue 592
type
sequence W
description BINDING SITE FOR RESIDUE W66 B 800
source : AC7

29) chain B
residue 593
type
sequence Y
description BINDING SITE FOR RESIDUE W66 B 800
source : AC7

30) chain B
residue 597
type
sequence E
description BINDING SITE FOR RESIDUE W66 B 800
source : AC7

31) chain B
residue 420
type BINDING
sequence C
description axial binding residue => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N
source Swiss-Prot : SWS_FT_FI2

32) chain B
residue 339
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N
source Swiss-Prot : SWS_FT_FI1

33) chain B
residue 483
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N
source Swiss-Prot : SWS_FT_FI1

34) chain B
residue 592
type BINDING
sequence W
description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N
source Swiss-Prot : SWS_FT_FI1

35) chain B
residue 593
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N
source Swiss-Prot : SWS_FT_FI1

36) chain B
residue 597
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N
source Swiss-Prot : SWS_FT_FI1

37) chain B
residue 682
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N
source Swiss-Prot : SWS_FT_FI1

38) chain B
residue 683
type BINDING
sequence W
description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N
source Swiss-Prot : SWS_FT_FI1

39) chain B
residue 696
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N
source Swiss-Prot : SWS_FT_FI1

40) chain B
residue 711
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N
source Swiss-Prot : SWS_FT_FI1


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