eF-site ID 5fvs-AB
PDB Code 5fvs
Chain A, B

click to enlarge
Title Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-methyl-6-(2-(5-(3-(methylamino)propyl)pyridin-3-yl) ethyl)pyridin-2-amine
Classification OXIDOREDUCTASE
Compound NITRIC OXIDE SYNTHASE, BRAIN
Source Rattus norvegicus (Rat) (NOS1_RAT)
Sequence A:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP
TKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIE
STSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDA
RDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGK
HDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQG
WKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHP
KFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYM
GTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQA
LVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCR
GGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPD
PWNTHVWK
B:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP
VRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKE
IESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVF
DARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTD
GKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQ
QGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIR
HPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGW
YMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKD
QALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYR
CRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQ
PDPWNTHVWKG
Description (1)  NITRIC OXIDE SYNTHASE, BRAIN (E.C.1.14.13.39)


Functional site

1) chain A
residue 409
type
sequence W
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

2) chain A
residue 415
type
sequence C
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

3) chain A
residue 457
type
sequence S
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

4) chain A
residue 584
type
sequence F
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

5) chain A
residue 585
type
sequence S
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

6) chain A
residue 586
type
sequence G
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

7) chain A
residue 587
type
sequence W
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

8) chain A
residue 589
type
sequence M
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

9) chain A
residue 592
type
sequence E
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

10) chain A
residue 678
type
sequence W
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

11) chain A
residue 704
type
sequence F
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

12) chain A
residue 706
type
sequence Y
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

13) chain A
residue 334
type
sequence S
description BINDING SITE FOR RESIDUE H4B A 760
source : AC2

14) chain A
residue 596
type
sequence R
description BINDING SITE FOR RESIDUE H4B A 760
source : AC2

15) chain A
residue 677
type
sequence V
description BINDING SITE FOR RESIDUE H4B A 760
source : AC2

16) chain A
residue 678
type
sequence W
description BINDING SITE FOR RESIDUE H4B A 760
source : AC2

17) chain B
residue 676
type
sequence W
description BINDING SITE FOR RESIDUE H4B A 760
source : AC2

18) chain B
residue 691
type
sequence F
description BINDING SITE FOR RESIDUE H4B A 760
source : AC2

19) chain B
residue 692
type
sequence H
description BINDING SITE FOR RESIDUE H4B A 760
source : AC2

20) chain B
residue 693
type
sequence Q
description BINDING SITE FOR RESIDUE H4B A 760
source : AC2

21) chain B
residue 694
type
sequence E
description BINDING SITE FOR RESIDUE H4B A 760
source : AC2

22) chain A
residue 478
type
sequence Q
description BINDING SITE FOR RESIDUE W66 A 800
source : AC3

23) chain A
residue 562
type
sequence Y
description BINDING SITE FOR RESIDUE W66 A 800
source : AC3

24) chain A
residue 588
type
sequence Y
description BINDING SITE FOR RESIDUE W66 A 800
source : AC3

25) chain A
residue 592
type
sequence E
description BINDING SITE FOR RESIDUE W66 A 800
source : AC3

26) chain A
residue 587
type
sequence W
description BINDING SITE FOR RESIDUE ACT A 860
source : AC4

27) chain A
residue 649
type
sequence V
description BINDING SITE FOR RESIDUE ACT A 860
source : AC4

28) chain A
residue 657
type
sequence S
description BINDING SITE FOR RESIDUE ACT A 860
source : AC4

29) chain B
residue 409
type
sequence W
description BINDING SITE FOR RESIDUE HEM B 750
source : AC5

30) chain B
residue 415
type
sequence C
description BINDING SITE FOR RESIDUE HEM B 750
source : AC5

31) chain B
residue 457
type
sequence S
description BINDING SITE FOR RESIDUE HEM B 750
source : AC5

32) chain B
residue 584
type
sequence F
description BINDING SITE FOR RESIDUE HEM B 750
source : AC5

33) chain B
residue 585
type
sequence S
description BINDING SITE FOR RESIDUE HEM B 750
source : AC5

34) chain B
residue 586
type
sequence G
description BINDING SITE FOR RESIDUE HEM B 750
source : AC5

35) chain B
residue 587
type
sequence W
description BINDING SITE FOR RESIDUE HEM B 750
source : AC5

36) chain B
residue 592
type
sequence E
description BINDING SITE FOR RESIDUE HEM B 750
source : AC5

37) chain B
residue 678
type
sequence W
description BINDING SITE FOR RESIDUE HEM B 750
source : AC5

38) chain B
residue 704
type
sequence F
description BINDING SITE FOR RESIDUE HEM B 750
source : AC5

39) chain B
residue 706
type
sequence Y
description BINDING SITE FOR RESIDUE HEM B 750
source : AC5

40) chain A
residue 676
type
sequence W
description BINDING SITE FOR RESIDUE H4B B 760
source : AC6

41) chain A
residue 691
type
sequence F
description BINDING SITE FOR RESIDUE H4B B 760
source : AC6

42) chain A
residue 692
type
sequence H
description BINDING SITE FOR RESIDUE H4B B 760
source : AC6

43) chain A
residue 694
type
sequence E
description BINDING SITE FOR RESIDUE H4B B 760
source : AC6

44) chain B
residue 334
type
sequence S
description BINDING SITE FOR RESIDUE H4B B 760
source : AC6

45) chain B
residue 596
type
sequence R
description BINDING SITE FOR RESIDUE H4B B 760
source : AC6

46) chain B
residue 677
type
sequence V
description BINDING SITE FOR RESIDUE H4B B 760
source : AC6

47) chain B
residue 678
type
sequence W
description BINDING SITE FOR RESIDUE H4B B 760
source : AC6

48) chain B
residue 478
type
sequence Q
description BINDING SITE FOR RESIDUE W66 B 800
source : AC7

49) chain B
residue 481
type
sequence R
description BINDING SITE FOR RESIDUE W66 B 800
source : AC7

50) chain B
residue 562
type
sequence Y
description BINDING SITE FOR RESIDUE W66 B 800
source : AC7

51) chain B
residue 586
type
sequence G
description BINDING SITE FOR RESIDUE W66 B 800
source : AC7

52) chain B
residue 587
type
sequence W
description BINDING SITE FOR RESIDUE W66 B 800
source : AC7

53) chain B
residue 588
type
sequence Y
description BINDING SITE FOR RESIDUE W66 B 800
source : AC7

54) chain B
residue 592
type
sequence E
description BINDING SITE FOR RESIDUE W66 B 800
source : AC7

55) chain B
residue 587
type
sequence W
description BINDING SITE FOR RESIDUE ACT B 860
source : AC8

56) chain A
residue 326
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1717
source : AC9

57) chain A
residue 331
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1717
source : AC9

58) chain B
residue 326
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1717
source : AC9

59) chain B
residue 331
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1717
source : AC9

60) chain A
residue 334
type BINDING
sequence S
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

61) chain B
residue 334
type BINDING
sequence S
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

62) chain B
residue 478
type BINDING
sequence Q
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

63) chain B
residue 587
type BINDING
sequence W
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

64) chain B
residue 588
type BINDING
sequence Y
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

65) chain B
residue 592
type BINDING
sequence E
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

66) chain B
residue 677
type BINDING
sequence V
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

67) chain B
residue 678
type BINDING
sequence W
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

68) chain B
residue 691
type BINDING
sequence F
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

69) chain B
residue 706
type BINDING
sequence Y
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

70) chain A
residue 478
type BINDING
sequence Q
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

71) chain A
residue 587
type BINDING
sequence W
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

72) chain A
residue 588
type BINDING
sequence Y
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

73) chain A
residue 592
type BINDING
sequence E
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

74) chain A
residue 677
type BINDING
sequence V
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

75) chain A
residue 678
type BINDING
sequence W
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

76) chain A
residue 691
type BINDING
sequence F
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

77) chain A
residue 706
type BINDING
sequence Y
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

78) chain A
residue 415
type BINDING
sequence C
description axial binding residue => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI2

79) chain B
residue 415
type BINDING
sequence C
description axial binding residue => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI2

80) chain A
residue 414-421
type prosite
sequence RCVGRIQW
description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW
source prosite : PS60001


Display surface

Download
Links