eF-site ID 5fvs-A
PDB Code 5fvs
Chain A

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Title Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-methyl-6-(2-(5-(3-(methylamino)propyl)pyridin-3-yl) ethyl)pyridin-2-amine
Classification OXIDOREDUCTASE
Compound NITRIC OXIDE SYNTHASE, BRAIN
Source Rattus norvegicus (Rat) (NOS1_RAT)
Sequence A:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP
TKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIE
STSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDA
RDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGK
HDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQG
WKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHP
KFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYM
GTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQA
LVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCR
GGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPD
PWNTHVWK
Description (1)  NITRIC OXIDE SYNTHASE, BRAIN (E.C.1.14.13.39)


Functional site

1) chain A
residue 409
type
sequence W
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

2) chain A
residue 415
type
sequence C
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

3) chain A
residue 457
type
sequence S
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

4) chain A
residue 584
type
sequence F
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

5) chain A
residue 585
type
sequence S
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

6) chain A
residue 586
type
sequence G
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

7) chain A
residue 587
type
sequence W
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

8) chain A
residue 589
type
sequence M
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

9) chain A
residue 592
type
sequence E
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

10) chain A
residue 678
type
sequence W
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

11) chain A
residue 704
type
sequence F
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

12) chain A
residue 706
type
sequence Y
description BINDING SITE FOR RESIDUE HEM A 750
source : AC1

13) chain A
residue 334
type
sequence S
description BINDING SITE FOR RESIDUE H4B A 760
source : AC2

14) chain A
residue 596
type
sequence R
description BINDING SITE FOR RESIDUE H4B A 760
source : AC2

15) chain A
residue 677
type
sequence V
description BINDING SITE FOR RESIDUE H4B A 760
source : AC2

16) chain A
residue 678
type
sequence W
description BINDING SITE FOR RESIDUE H4B A 760
source : AC2

17) chain A
residue 478
type
sequence Q
description BINDING SITE FOR RESIDUE W66 A 800
source : AC3

18) chain A
residue 562
type
sequence Y
description BINDING SITE FOR RESIDUE W66 A 800
source : AC3

19) chain A
residue 588
type
sequence Y
description BINDING SITE FOR RESIDUE W66 A 800
source : AC3

20) chain A
residue 592
type
sequence E
description BINDING SITE FOR RESIDUE W66 A 800
source : AC3

21) chain A
residue 587
type
sequence W
description BINDING SITE FOR RESIDUE ACT A 860
source : AC4

22) chain A
residue 649
type
sequence V
description BINDING SITE FOR RESIDUE ACT A 860
source : AC4

23) chain A
residue 657
type
sequence S
description BINDING SITE FOR RESIDUE ACT A 860
source : AC4

24) chain A
residue 676
type
sequence W
description BINDING SITE FOR RESIDUE H4B B 760
source : AC6

25) chain A
residue 691
type
sequence F
description BINDING SITE FOR RESIDUE H4B B 760
source : AC6

26) chain A
residue 692
type
sequence H
description BINDING SITE FOR RESIDUE H4B B 760
source : AC6

27) chain A
residue 694
type
sequence E
description BINDING SITE FOR RESIDUE H4B B 760
source : AC6

28) chain A
residue 326
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1717
source : AC9

29) chain A
residue 331
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1717
source : AC9

30) chain A
residue 334
type BINDING
sequence S
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

31) chain A
residue 478
type BINDING
sequence Q
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

32) chain A
residue 587
type BINDING
sequence W
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

33) chain A
residue 588
type BINDING
sequence Y
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

34) chain A
residue 592
type BINDING
sequence E
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

35) chain A
residue 677
type BINDING
sequence V
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

36) chain A
residue 678
type BINDING
sequence W
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

37) chain A
residue 691
type BINDING
sequence F
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

38) chain A
residue 706
type BINDING
sequence Y
description BINDING => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI1

39) chain A
residue 415
type BINDING
sequence C
description axial binding residue => ECO:0000250|UniProtKB:P29475
source Swiss-Prot : SWS_FT_FI2

40) chain A
residue 414-421
type prosite
sequence RCVGRIQW
description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW
source prosite : PS60001


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