eF-site ID 5fr2-A
PDB Code 5fr2
Chain A

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Title Farnesylated RhoA-GDP in complex with RhoGDI-alpha, lysine acetylated at K178
Classification SIGNALING PROTEIN
Compound TRANSFORMING PROTEIN RHOA
Source (GDIR1_BOVIN)
Sequence A:  MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFE
NYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVI
LMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD
LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECS
AKTKDGVREVFEMATRAALQAKKSGCL
Description


Functional site

1) chain A
residue 117
type MOD_RES
sequence N
description N-acetylalanine => ECO:0000250|UniProtKB:P52565
source Swiss-Prot : SWS_FT_FI1

2) chain A
residue 186
type LIPID
sequence K
description (Microbial infection) N6-stearoyl lysine => ECO:0000269|PubMed:30061757
source Swiss-Prot : SWS_FT_FI10

3) chain A
residue 187
type LIPID
sequence K
description (Microbial infection) N6-stearoyl lysine => ECO:0000269|PubMed:30061757
source Swiss-Prot : SWS_FT_FI10

4) chain A
residue 190
type LIPID
sequence C
description S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P61585
source Swiss-Prot : SWS_FT_FI11

5) chain A
residue 135
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23871831
source Swiss-Prot : SWS_FT_FI14

6) chain A
residue 59
type MOD_RES
sequence D
description Phosphoserine => ECO:0000250|UniProtKB:Q99PT1
source Swiss-Prot : SWS_FT_FI2

7) chain A
residue 160
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:Q99PT1
source Swiss-Prot : SWS_FT_FI2

8) chain A
residue 37
type CARBOHYD
sequence T
description (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
source Swiss-Prot : SWS_FT_FI13

9) chain A
residue 34
type CARBOHYD
sequence Y
description (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
source Swiss-Prot : SWS_FT_FI12


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