eF-site ID 5fpb-A PDB Code 5fpb Chain A click to enlarge Title Crystal structure of human KDM4D in complex with 2-1H-pyrazol-4-yloxy- 3H,4H-pyrido-3,4-d-pyrimidin-4-one Classification OXIDOREDUCTASE Compound LYSINE-SPECIFIC DEMETHYLASE 4D Source Homo sapiens (Human) (KDM4D_HUMAN) Sequence A:  AQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAK IIPPKEWKARETYDNISEILIATPLQQVASGRAGVFTQYH KKKKAMTVGEYRHLANSKKYQTPPHQNFEDLERKYWKNRI YNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGV VIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPK TWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALIS PTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCA EAINFATPRWIDYGKMASQCSCGEARVTFSMDAFVRILQP ERYDLWKRGQ Description Functional site 1) chain A residue 238 type sequence C description BINDING SITE FOR RESIDUE ZN A 350 source : AC1 2) chain A residue 244 type sequence H description BINDING SITE FOR RESIDUE ZN A 350 source : AC1 3) chain A residue 310 type sequence C description BINDING SITE FOR RESIDUE ZN A 350 source : AC1 4) chain A residue 312 type sequence C description BINDING SITE FOR RESIDUE ZN A 350 source : AC1 5) chain A residue 192 type sequence H description BINDING SITE FOR RESIDUE CO A 360 source : AC2 6) chain A residue 194 type sequence E description BINDING SITE FOR RESIDUE CO A 360 source : AC2 7) chain A residue 280 type sequence H description BINDING SITE FOR RESIDUE CO A 360 source : AC2 8) chain A residue 90 type sequence H description BINDING SITE FOR RESIDUE HA6 A 1341 source : AC3 9) chain A residue 136 type sequence Y description BINDING SITE FOR RESIDUE HA6 A 1341 source : AC3 10) chain A residue 138 type sequence A description BINDING SITE FOR RESIDUE HA6 A 1341 source : AC3 11) chain A residue 181 type sequence Y description BINDING SITE FOR RESIDUE HA6 A 1341 source : AC3 12) chain A residue 188 type sequence T description BINDING SITE FOR RESIDUE HA6 A 1341 source : AC3 13) chain A residue 189 type sequence F description BINDING SITE FOR RESIDUE HA6 A 1341 source : AC3 14) chain A residue 192 type sequence H description BINDING SITE FOR RESIDUE HA6 A 1341 source : AC3 15) chain A residue 210 type sequence K description BINDING SITE FOR RESIDUE HA6 A 1341 source : AC3 16) chain A residue 212 type sequence W description BINDING SITE FOR RESIDUE HA6 A 1341 source : AC3 17) chain A residue 245 type sequence K description BINDING SITE FOR RESIDUE HA6 A 1341 source : AC3 18) chain A residue 280 type sequence H description BINDING SITE FOR RESIDUE HA6 A 1341 source : AC3 19) chain A residue 179 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 1342 source : AC4 20) chain A residue 181 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 1342 source : AC4 21) chain A residue 194 type sequence E description BINDING SITE FOR RESIDUE SO4 A 1342 source : AC4 22) chain A residue 292 type sequence A description BINDING SITE FOR RESIDUE SO4 A 1342 source : AC4 23) chain A residue 294 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1342 source : AC4 24) chain A residue 60 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1343 source : AC5 25) chain A residue 61 type sequence E description BINDING SITE FOR RESIDUE SO4 A 1343 source : AC5 26) chain A residue 62 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1343 source : AC5 27) chain A residue 65 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1343 source : AC5 28) chain A residue 123 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1344 source : AC6 29) chain A residue 124 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1344 source : AC6 30) chain A residue 127 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1344 source : AC6 31) chain A residue 128 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1344 source : AC6 32) chain A residue 113 type sequence P description BINDING SITE FOR RESIDUE SO4 A 1345 source : AC7 33) chain A residue 124 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1345 source : AC7 34) chain A residue 128 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1345 source : AC7 35) chain A residue 185 type sequence W description BINDING SITE FOR RESIDUE SO4 A 1345 source : AC7 36) chain A residue 186 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1345 source : AC7 37) chain A residue 102 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1346 source : AC8 38) chain A residue 103 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1346 source : AC8 39) chain A residue 106 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1346 source : AC8 40) chain A residue 116 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1347 source : AC9 41) chain A residue 116 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1347 source : AC9 42) chain A residue 117 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1347 source : AC9 43) chain A residue 117 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1347 source : AC9 44) chain A residue 302 type sequence D description BINDING SITE FOR RESIDUE SO4 A 1348 source : BC1 45) chain A residue 303 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 1348 source : BC1 46) chain A residue 306 type sequence M description BINDING SITE FOR RESIDUE SO4 A 1348 source : BC1 47) chain A residue 136 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI1 48) chain A residue 202 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI1 49) chain A residue 210 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI1 50) chain A residue 245 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI1 51) chain A residue 192 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 52) chain A residue 194 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 53) chain A residue 280 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 54) chain A residue 238 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F5A, ECO:0007744|PDB:5F5C source Swiss-Prot : SWS_FT_FI3 55) chain A residue 244 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F5A, ECO:0007744|PDB:5F5C source Swiss-Prot : SWS_FT_FI3 56) chain A residue 310 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F5A, ECO:0007744|PDB:5F5C source Swiss-Prot : SWS_FT_FI3 57) chain A residue 312 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F5A, ECO:0007744|PDB:5F5C source Swiss-Prot : SWS_FT_FI3 58) chain A residue 26 type MOD_RES sequence E description PolyADP-ribosyl glutamic acid => ECO:0000269|PubMed:23102699 source Swiss-Prot : SWS_FT_FI4 59) chain A residue 27 type MOD_RES sequence E description PolyADP-ribosyl glutamic acid => ECO:0000269|PubMed:23102699 source Swiss-Prot : SWS_FT_FI4

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