eF-site ID 5fp9-A PDB Code 5fp9 Chain A click to enlarge Title Crystal structure of human KDM4D in complex with 3-aminopyridine-4- carboxylic acid Classification OXIDOREDUCTASE Compound HUMAN LYSINE-SPECIFIC DEMETHYLASE 4D JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN 3D, JUMONJI DOMAIN-CONTAINING PROTEIN 2D, JMJD2D Source Homo sapiens (Human) (KDM4D_HUMAN) Sequence A:  AQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAK IIPPKEWKARETYDNISEILIATPLQQVASGRAGVFTQYH KKKKAMTVGEYRHLANSKKYQTPPHQNFEDLERKYWKNRI YNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKEXGV VIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPK TWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALIS PTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCA EAINFATPRWIDYGKMASQCSCGEARSMDAFVRILQPERY DLWKRGQ Description (1)  HUMAN LYSINE-SPECIFIC DEMETHYLASE 4D JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN 3D, JUMONJI DOMAIN-CONTAINING PROTEIN 2D, JMJD2D (E.C.1.14.11.-) Functional site 1) chain A residue 238 type sequence C description BINDING SITE FOR RESIDUE ZN A 350 source : AC1 2) chain A residue 244 type sequence H description BINDING SITE FOR RESIDUE ZN A 350 source : AC1 3) chain A residue 310 type sequence C description BINDING SITE FOR RESIDUE ZN A 350 source : AC1 4) chain A residue 312 type sequence C description BINDING SITE FOR RESIDUE ZN A 350 source : AC1 5) chain A residue 192 type sequence H description BINDING SITE FOR RESIDUE CO A 360 source : AC2 6) chain A residue 194 type sequence E description BINDING SITE FOR RESIDUE CO A 360 source : AC2 7) chain A residue 280 type sequence H description BINDING SITE FOR RESIDUE CO A 360 source : AC2 8) chain A residue 31 type sequence F description BINDING SITE FOR RESIDUE GOL A 1341 source : AC3 9) chain A residue 150 type sequence K description BINDING SITE FOR RESIDUE GOL A 1341 source : AC3 10) chain A residue 151 type sequence Q description BINDING SITE FOR RESIDUE GOL A 1341 source : AC3 11) chain A residue 152 type sequence W description BINDING SITE FOR RESIDUE GOL A 1341 source : AC3 12) chain A residue 153 type sequence N description BINDING SITE FOR RESIDUE GOL A 1341 source : AC3 13) chain A residue 156 type sequence H description BINDING SITE FOR RESIDUE GOL A 1341 source : AC3 14) chain A residue 136 type sequence Y description BINDING SITE FOR RESIDUE 4SV A 1342 source : AC4 15) chain A residue 189 type sequence F description BINDING SITE FOR RESIDUE 4SV A 1342 source : AC4 16) chain A residue 192 type sequence H description BINDING SITE FOR RESIDUE 4SV A 1342 source : AC4 17) chain A residue 210 type sequence K description BINDING SITE FOR RESIDUE 4SV A 1342 source : AC4 18) chain A residue 212 type sequence W description BINDING SITE FOR RESIDUE 4SV A 1342 source : AC4 19) chain A residue 280 type sequence H description BINDING SITE FOR RESIDUE 4SV A 1342 source : AC4 20) chain A residue 113 type sequence P description BINDING SITE FOR RESIDUE SO4 A 1343 source : AC5 21) chain A residue 124 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1343 source : AC5 22) chain A residue 128 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1343 source : AC5 23) chain A residue 185 type sequence W description BINDING SITE FOR RESIDUE SO4 A 1343 source : AC5 24) chain A residue 186 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1343 source : AC5 25) chain A residue 60 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1344 source : AC6 26) chain A residue 61 type sequence E description BINDING SITE FOR RESIDUE SO4 A 1344 source : AC6 27) chain A residue 62 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1344 source : AC6 28) chain A residue 65 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1344 source : AC6 29) chain A residue 123 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1345 source : AC7 30) chain A residue 124 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1345 source : AC7 31) chain A residue 127 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1345 source : AC7 32) chain A residue 128 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1345 source : AC7 33) chain A residue 102 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1346 source : AC8 34) chain A residue 103 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1346 source : AC8 35) chain A residue 106 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1346 source : AC8 36) chain A residue 116 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1347 source : AC9 37) chain A residue 116 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1347 source : AC9 38) chain A residue 117 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1347 source : AC9 39) chain A residue 117 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1347 source : AC9 40) chain A residue 302 type sequence D description BINDING SITE FOR RESIDUE SO4 A 1348 source : BC1 41) chain A residue 303 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 1348 source : BC1 42) chain A residue 306 type sequence M description BINDING SITE FOR RESIDUE SO4 A 1348 source : BC1 43) chain A residue 179 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 1349 source : BC2 44) chain A residue 181 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 1349 source : BC2 45) chain A residue 194 type sequence E description BINDING SITE FOR RESIDUE SO4 A 1349 source : BC2 46) chain A residue 292 type sequence A description BINDING SITE FOR RESIDUE SO4 A 1349 source : BC2 47) chain A residue 293 type sequence I description BINDING SITE FOR RESIDUE SO4 A 1349 source : BC2 48) chain A residue 294 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1349 source : BC2 49) chain A residue 136 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI1 50) chain A residue 202 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI1 51) chain A residue 210 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI1 52) chain A residue 245 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI1 53) chain A residue 192 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 54) chain A residue 194 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 55) chain A residue 280 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 56) chain A residue 238 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F5A, ECO:0007744|PDB:5F5C source Swiss-Prot : SWS_FT_FI3 57) chain A residue 244 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F5A, ECO:0007744|PDB:5F5C source Swiss-Prot : SWS_FT_FI3 58) chain A residue 310 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F5A, ECO:0007744|PDB:5F5C source Swiss-Prot : SWS_FT_FI3 59) chain A residue 312 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F5A, ECO:0007744|PDB:5F5C source Swiss-Prot : SWS_FT_FI3 60) chain A residue 26 type MOD_RES sequence E description PolyADP-ribosyl glutamic acid => ECO:0000269|PubMed:23102699 source Swiss-Prot : SWS_FT_FI4 61) chain A residue 27 type MOD_RES sequence E description PolyADP-ribosyl glutamic acid => ECO:0000269|PubMed:23102699 source Swiss-Prot : SWS_FT_FI4

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