eF-site ID 5fob-B PDB Code 5fob Chain B click to enlarge Title Crystal Structure of Human Complement C3b in complex with Smallpox Inhibitor of Complement (SPICE) Classification LIPID BINDING PROTEIN Compound COMPLEMENT C3 BETA CHAIN Source ORGANISM_COMMON: HUMAN; ORGANISM_SCIENTIFIC: HOMO SAPIENS; Sequence B:  EDIIAEENIVSRSEFPESWLWNVEDLKEPPKNGISTKLMN IFLKDSITTWEILAVSMSDKKGICVADPFEVTVMQDFFID LRLPYSVVRNEQVEIRAVLYNYRQNQELKVRVELLHNPAF CSLATTKRRHQQTVTIPPKSSLSVPYVIVPLKTGLQEVEV KAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPERL GREGVQKEDIPPADLSDQVPDTESETRILLQGTPVAQMTE DAVDAERLKHLIVTPSGCGEENMIGMTPTVIAVHYLDETE QWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVKR APSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQ KPDGVFQEDAPVIHQEMIGGLRNNNEKDMALTAFVLISLQ EAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAIA GYALAQMGRLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEA TSYALLALLQLKDFDFVPPVVRWLNEQRYYGGGYGSTQAT FMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIH WESASLLRSEETKENEGFTVTAEGKGQGTLSVVTMYHAKA KDQLTCNKFDLKVTIKPAPKNTMILEICTRYRGDQDATMS ILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSDR NTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYA YYNLEESCTRFYHPEKEDGKLNKLCRDELCRCAEENCFIQ KSDDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDEY IMAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKH YLMWGLSSDFWGEKPNLSYIIGKDTWVEHWPEEDECQDEE NQKQCQDLGAFTESMVVFGCPN Description Functional site 1) chain B residue 1617 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952 source Swiss-Prot : SWS_FT_FI6 2) chain B residue 1010 type CROSSLNK sequence C description Isoglutamyl cysteine thioester (Cys-Gln) source Swiss-Prot : SWS_FT_FI7 3) chain B residue 1013 type CROSSLNK sequence E description Isoglutamyl cysteine thioester (Cys-Gln) source Swiss-Prot : SWS_FT_FI7 4) chain B residue 954 type SITE sequence R description Cleavage; by factor I => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 5) chain B residue 1320 type SITE sequence R description Cleavage; by factor I source Swiss-Prot : SWS_FT_FI2 6) chain B residue 1303 type SITE sequence R description Cleavage; by factor I source Swiss-Prot : SWS_FT_FI2 7) chain B residue 1663 type SITE sequence N description Coordinates Mg2+ for interaction with Complement factor B Bb fragment => ECO:0000269|PubMed:28264884, ECO:0000269|PubMed:31507604 source Swiss-Prot : SWS_FT_FI3 8) chain B residue 1573 type MOD_RES sequence S description Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039 source Swiss-Prot : SWS_FT_FI4 9) chain B residue 968 type MOD_RES sequence S description Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039 source Swiss-Prot : SWS_FT_FI4 10) chain B residue 1321 type MOD_RES sequence S description Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039 source Swiss-Prot : SWS_FT_FI4 11) chain B residue 939 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17051150 source Swiss-Prot : SWS_FT_FI5 12) chain B residue 1007-1015 type prosite sequence PSGCGEENM description ALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PsGCGEEnM source prosite : PS00477

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