eF-site ID 5fnq-A PDB Code 5fnq Chain A click to enlarge Title Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor. Classification TRANSCRIPTION Compound KELCH-LIKE ECH-ASSOCIATED PROTEIN 1 Source Mus musculus (Mouse) (KEAP1_MOUSE) Sequence A:  VGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRS GLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQW SPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERY EPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR LNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAG GYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQ GKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSG VGVAVTMEPC Description Functional site 1) chain A residue 415 type sequence R description BINDING SITE FOR RESIDUE S0W A 1614 source : AC1 2) chain A residue 478 type sequence F description BINDING SITE FOR RESIDUE S0W A 1614 source : AC1 3) chain A residue 483 type sequence R description BINDING SITE FOR RESIDUE S0W A 1614 source : AC1 4) chain A residue 508 type sequence S description BINDING SITE FOR RESIDUE S0W A 1614 source : AC1 5) chain A residue 509 type sequence G description BINDING SITE FOR RESIDUE S0W A 1614 source : AC1 6) chain A residue 556 type sequence A description BINDING SITE FOR RESIDUE S0W A 1614 source : AC1 7) chain A residue 434 type SITE sequence C description Sensor for electrophilic agents => ECO:0000269|PubMed:20498371 source Swiss-Prot : SWS_FT_FI1 8) chain A residue 434 type MOD_RES sequence C description S-cGMP-cysteine => ECO:0000269|PubMed:20498371 source Swiss-Prot : SWS_FT_FI2 9) chain A residue 613 type MOD_RES sequence C description S-(2-succinyl)cysteine => ECO:0000269|PubMed:22014577 source Swiss-Prot : SWS_FT_FI3

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