eF-site ID 5flm-A PDB Code 5flm Chain A click to enlarge Title Structure of transcribing mammalian RNA polymerase II Classification TRANSCRIPTION Compound DNA-DIRECTED RNA POLYMERASE Source ORGANISM_COMMON: BOVINE; ORGANISM_SCIENTIFIC: BOS TAURUS; Sequence A:  SACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGG RPKLGGLMDPRQGVIERTGRCQTCAGNMTECPGHFGHIEL AKPVFHVGFLVKTMKVLRCVCFFCSKLLVDSNNPKIKDIL AKSKGQPKKRLTHVYDLCKGKNICEHGGCGRYQPRIRRSG LELYAEWKKILLSPERVHEIFKRISDEECFVLGMEPRYAR PEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIV KINNQLRRNEQNGAAAHVIAEDVKLLQFHVATMVDNELPG LPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVDFSAR TVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQE LVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGY KVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRL NLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRM IVTPQSNRPVMGIVQDTLTAVRKFTKRDVFLERGEVMNLL MFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHINCIR THSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKS LGTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEG HTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKAHNNE LEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYN NFKSMVVSGAKGSKINISQVIAVVGQQNVEGKRIPFGFKH RTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGR EGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSIN QVVQLRYGEDGLAGESVEFQNLATLKPSNKAFEKKFRFDY TNERALRRTLQEDLVKDVLSNAHIQNELEREFERMREDRE VLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDL HPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIH LRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPG EMVGALAAQSLGEPATQMTLNTFHKNVTLGVPRLKELINI SKKPKTPSLTVFLLGQSARDAERAKDILCRLEHTTLRKVT ANTAIYYDPNPQSTVVAEDQEWVNVYYEMPDFDVARISPW LLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDD NAEKLVLRIRIMNSDENKMDDDVFLRCIESNMLTDMTLQG IEQISKVYMHLPQTDNKKKIIITEDGEFKALQEWILETDG VSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVN RQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIML GQLAPAGTGCFDLLLDAEKCKYGMEIP Description (1)  DNA-DIRECTED RNA POLYMERASE (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4 Functional site 1) chain A residue 71 type sequence C description BINDING SITE FOR RESIDUE ZN A 2488 source : AC1 2) chain A residue 73 type sequence T description BINDING SITE FOR RESIDUE ZN A 2488 source : AC1 3) chain A residue 74 type sequence C description BINDING SITE FOR RESIDUE ZN A 2488 source : AC1 4) chain A residue 81 type sequence C description BINDING SITE FOR RESIDUE ZN A 2488 source : AC1 5) chain A residue 84 type sequence H description BINDING SITE FOR RESIDUE ZN A 2488 source : AC1 6) chain A residue 111 type sequence C description BINDING SITE FOR RESIDUE ZN A 2489 source : AC2 7) chain A residue 114 type sequence C description BINDING SITE FOR RESIDUE ZN A 2489 source : AC2 8) chain A residue 154 type sequence C description BINDING SITE FOR RESIDUE ZN A 2489 source : AC2 9) chain A residue 183 type sequence G description BINDING SITE FOR RESIDUE ZN A 2489 source : AC2 10) chain A residue 184 type sequence C description BINDING SITE FOR RESIDUE ZN A 2489 source : AC2 11) chain A residue 495 type sequence D description BINDING SITE FOR RESIDUE MG A 2490 source : AC3 12) chain A residue 497 type sequence D description BINDING SITE FOR RESIDUE MG A 2490 source : AC3 13) chain A residue 499 type sequence D description BINDING SITE FOR RESIDUE MG A 2490 source : AC3 14) chain A residue 154 type MOD_RES sequence C description Phosphoserine; by CK2 => ECO:0000250|UniProtKB:O88828 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 1421 type MOD_RES sequence R description Phosphoserine; by CK2 => ECO:0000250|UniProtKB:O88828 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 27 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P24928 source Swiss-Prot : SWS_FT_FI7 17) chain A residue 217 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P24928 source Swiss-Prot : SWS_FT_FI7 18) chain A residue 71 type BINDING sequence C description BINDING => ECO:0000269|PubMed:26789250, ECO:0000269|PubMed:28892040, ECO:0007744|PDB:5FLM, ECO:0007744|PDB:5OIK source Swiss-Prot : SWS_FT_FI2 19) chain A residue 499 type BINDING sequence D description BINDING => ECO:0000269|PubMed:26789250, ECO:0000269|PubMed:28892040, ECO:0007744|PDB:5FLM, ECO:0007744|PDB:5OIK source Swiss-Prot : SWS_FT_FI2 20) chain A residue 1416 type BINDING sequence R description BINDING => ECO:0000269|PubMed:26789250, ECO:0000269|PubMed:28892040, ECO:0007744|PDB:5FLM, ECO:0007744|PDB:5OIK source Swiss-Prot : SWS_FT_FI2 21) chain A residue 74 type BINDING sequence C description BINDING => ECO:0000269|PubMed:26789250, ECO:0000269|PubMed:28892040, ECO:0007744|PDB:5FLM, ECO:0007744|PDB:5OIK source Swiss-Prot : SWS_FT_FI2 22) chain A residue 81 type BINDING sequence C description BINDING => ECO:0000269|PubMed:26789250, ECO:0000269|PubMed:28892040, ECO:0007744|PDB:5FLM, ECO:0007744|PDB:5OIK source Swiss-Prot : SWS_FT_FI2 23) chain A residue 84 type BINDING sequence H description BINDING => ECO:0000269|PubMed:26789250, ECO:0000269|PubMed:28892040, ECO:0007744|PDB:5FLM, ECO:0007744|PDB:5OIK source Swiss-Prot : SWS_FT_FI2 24) chain A residue 111 type BINDING sequence C description BINDING => ECO:0000269|PubMed:26789250, ECO:0000269|PubMed:28892040, ECO:0007744|PDB:5FLM, ECO:0007744|PDB:5OIK source Swiss-Prot : SWS_FT_FI2 25) chain A residue 114 type BINDING sequence C description BINDING => ECO:0000269|PubMed:26789250, ECO:0000269|PubMed:28892040, ECO:0007744|PDB:5FLM, ECO:0007744|PDB:5OIK source Swiss-Prot : SWS_FT_FI2 26) chain A residue 184 type BINDING sequence C description BINDING => ECO:0000269|PubMed:26789250, ECO:0000269|PubMed:28892040, ECO:0007744|PDB:5FLM, ECO:0007744|PDB:5OIK source Swiss-Prot : SWS_FT_FI2 27) chain A residue 346 type BINDING sequence K description BINDING => ECO:0000269|PubMed:26789250, ECO:0000269|PubMed:28892040, ECO:0007744|PDB:5FLM, ECO:0007744|PDB:5OIK source Swiss-Prot : SWS_FT_FI2 28) chain A residue 460 type BINDING sequence R description BINDING => ECO:0000269|PubMed:26789250, ECO:0000269|PubMed:28892040, ECO:0007744|PDB:5FLM, ECO:0007744|PDB:5OIK source Swiss-Prot : SWS_FT_FI2 29) chain A residue 493 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P24928 source Swiss-Prot : SWS_FT_FI4 30) chain A residue 495 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P24928 source Swiss-Prot : SWS_FT_FI4 31) chain A residue 497 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P04050 source Swiss-Prot : SWS_FT_FI5 32) chain A residue 358 type BINDING sequence R description BINDING => ECO:0000269|PubMed:28892040, ECO:0007744|PDB:5OIK source Swiss-Prot : SWS_FT_FI3

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