eF-site ID
|
5fja-ABCDEFGHIJKLMNOPQ |
PDB Code
|
5fja |
Chain
|
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q |
|
|
|
Title
|
Cryo-EM structure of yeast RNA polymerase III at 4.7 A |
Classification
|
TRANSCRIPTION |
Compound
|
DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1 |
Source
|
ORGANISM_COMMON: BAKER'S YEAST; ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE; |
|
Sequence
|
A: |
KEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFD
LEKDRAPKANGALDPKMGVSSSSLECATCHGNLASCHGHF
GHLKLALPVFHIGYFKATIQILQGICKNCSAILLSETDKR
QFLHELRRPGVDNLRRMGILKKILDQCKKQRRCLHCGALN
GVVKKAAALKIIHDTFRWVGKKSAPEKDIWVGEWKEVLAH
NPELERYVKRCMDDLNPLKTLNLFKQIKSADCELLGIDAT
VPSGRPETYIWRYLPAPPVCIRPSVMMQDSPASNEDDLTV
KLTEIVWTSSLIKAGLDKGISINNMMEHWDYLQLTVAMYI
NKPIRGFCQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPN
LSIDEVAVPDRVAKVLTYPEKVTRYNRHKLQELIVNGPNV
HPGANYLLKRNEDARRNLRYGDRMKLAKNLQIGDVVERHL
EDGDVVLFNRQPSLHRLSILSHYAKIRPWRTFRLNECVCT
PYNADFDGDEMNLHVPQTEEARAEAINLMGVKNNLLTPKS
GEPIIAATQDFITGSYLISHKDSFYDRATLTQLLSMMSDG
IEHFDIPPPAIMKPYYLWTGKQVFSLLIKPNHNSPVVINL
DAKNKVFVPPKSKSLPNEMSQNDGFVIIRGSQILSGVMDK
SVLGDGKKHSVFYTILRDYGPQEAANAMNRMAKLCARFLG
NRGFSIGINDVTPADDLKQKKEELVEIAYHKCDELITLFN
KGELETQPGCNEEQTLEAKIGGLLSKVREEVGDVCINELD
NWNAPLIMATCGSKGSTLNVSQMVAVVGQQIISGNRVPDG
FQDRSLPHFPKNSKTPQSKGFVRNSFFSGLSPPEFLFHAI
SGREGLVDTAVKTAETGYMSRRLMKSLEDLSCQYDNTVRT
SANGIVQFTYGGDGLDPLEMEGNAQPVNFNRSWDHAYNIT
FNNQDKGLLPYAIMETANEILGPLEERLVRYDNSGCLVKR
EDLNKAEYVDQYDAERDFYHSLREYINGKATALANLRKSR
GMLGLLEPPAKELQGIDPDETVPDNVKTSVSQLYRISEKS
VRKFLEIALFKYRKARLEPGTAIGAIGAQSIGEPMNVTLG
VPRIKEIINASKVISTPIINAVLVNDNDERAARVVKGRVE
KTLLSDVAFYVQDVYKDNLSFIQVRIDLGTIDKLQLELTI
EDIAVAITRASKLKIQASDVNIIGKDRIAINVFPSENDVF
YRMQQLRRALPDVVVKGLPDISRAVINIRDDGKRELLVEG
YGLRDVMCTDGVIGSRTTTNHVLEVFSVLGIEAARYSIIR
EINYTMSNHGMSVDPRHIQLLGDVMTYKGEVLGITRFGLS
KMRDSVLQLASFEKTTDHLFDAAFYMKKDAVEGVSECIIL
GQTMSIGTGSFKVVKGTNISEKDLVPKRCLFESLSNEAAL
KAN
|
B: |
DEINTAQDKWHLLPAFLKVKGLVKQHLDSFNYFVDTDLKK
IIKANQLILSDVDPEFYLKYVDIRVGKKSSSSTKDYLTPP
HECRLRDMTYSAPIYVDIEYTRGRNIIMHKDVEIGRMPIM
LRSNKCILYDADESKMAKLNECPLDPGGYFIVNGTEKVIL
VQEQLSKNRIIVEADEKKGIVQASVTSSTHERKSKTYVIT
KNGKIYLKHNSIAEEIPIAIVLKACGILSDLEIMQLVCGN
DSSYQDIFAVNLEESSKLDIYTQQQALEYIGAKVKTMRRQ
KLTILQEGIEAIATTVIAHLTVEALDFREKALYIAMMTRR
VVMAMYNPKMIDDRDYVGNKRLELAGQLISLLFEDLFKKF
NNDFKLSIDKVLKKPNRAMEYDALLSINVHSNNITSGLNR
AISTGNWSLKRFKMERAGVTHVLSRLSYISALGMMTRISS
QFEKSRKVSGPRALQPSQFGMLCTADTPEGEACGLVKNLA
LMTHITTDDEEEPIKKLCYVLGVEDITLIDSASLHLNYGV
YLNGTLIGSIRFPTKFVTQFRHLRRTGKVSEFISIYSNSH
QMAVHIATDGGRICRPLIIVSDGQSRVKDIHLRKLLDGEL
DFDDFLKLGLVEYLDVNEENDSYIALYEKDIVPSMTHLEI
EPFTILGAVAGLIPYPHHNQSPRNTYQCAMGKQAIGAIAY
NQFKRIDTLLYLMTYPQQPMVKTKTIELIDYDKLPAGQNA
TVAVMSYSGYDIEDALVLNKSSIDRGFGRCETRRKTTTVL
KRYANHTQDIIGGMRVDENGDPIWQHQSLGPDGLGEVGMK
VQSGQIYINKSVPTNSADAPNPNNVNVQTQYREAPVIYRG
PEPSHIDQVMMSVSDNDQALIKVLLRQNRRPELGDKFSSR
HGQKGVCGIIVKQEDMPFNDQGIVPDIIMNPHGFPSRMTV
GKMIELISGKAGVLNGTLEYGTCFGGSKLEDMSKILVDQG
FNYSGKDMLYSGITGECLQAYIFFGPIYYQKLKHMVLDKM
HARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCVIAYGA
SQLLLERLMISSDAFEVDVCDKCGLMGYSGWCTTCKSAEN
IIKMTIPYAAKLLFQELLSMNIAPRLRLEDIFQQ
|
C: |
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDF
EVNISSLDAREANFDLINIDTSIANAFRRIMISEVPSVAA
EYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNL
PDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNA
HVYARDLKFEPQGRQSTTFADCPVVPADPDILLAKLRPGQ
EISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIK
GESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVL
RYEEFADKVKLGRVRNHFIFNVESAGAMTPEEIFFKSVRI
LKNKAEYLKNCPITQ
|
D: |
MKVLEERNAFLSDYEVLKFLTDLEKKHLWDQKSLAPELQG
ITRNVVNYLSINKNFMSDESFAELMTKLNSFKLFKAEKLQ
IVNQLPANMVHLYSIVEECDARFDEKTIEEMLEIISGYA
|
E: |
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLE
DFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWV
EFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDE
KRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIR
KSETSGRYASYRICM
|
F: |
EKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVD
LEGETDPLRIAMKELAEKKIPLVIRRYLPDGSFEDWSVEE
LIV
|
G: |
FILSKIADLVRIPPDQFHRDTISAITHQLNNKFANKIIPN
VGLCITIYDLLTVEEGQLKPGDGSSYINVTFRAVVFKPFL
GEIVTGWISKCTAEGIKVSLLGIFDDIFIPQNMLFEGCYY
TPEESAWIWPKLYFDVNEKIRFRIEREVFVDVKPKSPKEK
PPAYALLGSCQTDGMGLVSWWE
|
H: |
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTL
DINVELFPVAAQDSLTVTIASSLNLEDSATRSWRPPQAGD
RSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGGLLMRLE
GNYRNLNNLKQENAYLLIRR
|
I: |
MLSFCPSCNNMLLITSGDSGVYTLACRSCPYEFPIEGIEI
YDNVDQTKTQCPNYDTCGGESAYFFQLQIRSADEPMTTFY
KCVNCGHRWKEN
|
J: |
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLG
LKRYCCRRMILTHVDLIEKFLRYNPLE
|
K: |
PDREKIKLLTQATSEDGTSASFQIVEEDHTLGNALRYVIM
KNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQKGL
KDLMDLCDVVESKFTEKIKSM
|
L: |
TLKYICAECSSKLSLSRTDAVRCKDCGHRILLKARTKRLV
QFEAR
|
M: |
IEEFPLKISGEEESLHVFQYANRPRLVGRKPAEHPFISAA
RYKPKSHLWEIDIPLDEQAFYNKDKAESEWNGVNVQTLKG
VGVENNGQYAAFVKDMQVYLVPIERVAQLKPFFKYIDDAN
VTRKQENRLTGSLLAHKVADEEANIELTWAEGTFEQFKDT
IVKE
|
N: |
KEAAAELELLNADHQHILRKLKKMNNKPERFMVFQLPTRL
PAFERPAVGSIRVHKSGKLSVKIGNVVMDIGKGAETTFLQ
DVIALSIADDASSAELLGRVDGKIVVTPQI
|
O: |
VMTISSLEQRTLNPDLFLYKELVKAHLGERAASVIGMLVA
LGRLSVRELVEKIDGMDVDSVKTTLVSLTQLRCVKYLQET
AISGKKTTYYYYNEEGIHILLYSGLIIDEIITQMRVNDEE
EHKQLVAEIVQNVISLGSLTVEDYLSSVTSDSMKYTISSL
FVQLCEMGYLIQISKLHYTPIEDLWQFLYEKHYKNIPRNS
PLSDLKKRSQAKMNAKTDFAKIINKPNELSQILTVDPKTS
LRIVKPTVSLTINLDRFMKGRRSKQLINLAKTRVGSVTAQ
VYKIALRLTEQKSPKIRDPLTQTGLLQDLEEAKSFQDEAE
LVEEKTPGLTFNAIDLARHLPSASLINSHLKILASSNFPF
LNETKPGVYYVPYSKLMPVLKSSVYEYVIASTLGPSAMRL
SRCIRDNKLVSEKIINSTALMKEKDIRSTLASLIRYNSVE
IQEVPRTADRSASRAVFLFRCKETHSYNFMRQNLEWNMAN
LLFKKEKLKQENSTLLKKANRDDLLPSELNQLKMVNEREL
NVFARLSRLLSLWEVFQMA
|
P: |
DIEFINSLLTIVWRFISENYSTTQEILEFITAAQVANVEL
TPSNIRSLCEVLVYDDKLEKVTHDCYRVTLESILQMSKHD
KEVVYFDEW
|
Q: |
PINGPITNKERSLAVKYINFGKTVKDGPXXXXXXXXXXXX
XXXXXXX
|
|
Description
|
(1) |
DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1 (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2 (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1, DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2, DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3, DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5, DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4, DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5, DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4, DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3, DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6, DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7
|
|
|
|
1)
|
chain |
A |
residue |
67 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN A 2000
|
source |
: AC1
|
|
2)
|
chain |
A |
residue |
69 |
type |
|
sequence |
T
|
description |
BINDING SITE FOR RESIDUE ZN A 2000
|
source |
: AC1
|
|
3)
|
chain |
A |
residue |
70 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN A 2000
|
source |
: AC1
|
|
4)
|
chain |
A |
residue |
77 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN A 2000
|
source |
: AC1
|
|
5)
|
chain |
A |
residue |
80 |
type |
|
sequence |
H
|
description |
BINDING SITE FOR RESIDUE ZN A 2000
|
source |
: AC1
|
|
6)
|
chain |
A |
residue |
107 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN A 2001
|
source |
: AC2
|
|
7)
|
chain |
A |
residue |
109 |
type |
|
sequence |
N
|
description |
BINDING SITE FOR RESIDUE ZN A 2001
|
source |
: AC2
|
|
8)
|
chain |
A |
residue |
110 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN A 2001
|
source |
: AC2
|
|
9)
|
chain |
A |
residue |
154 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN A 2001
|
source |
: AC2
|
|
10)
|
chain |
A |
residue |
156 |
type |
|
sequence |
H
|
description |
BINDING SITE FOR RESIDUE ZN A 2001
|
source |
: AC2
|
|
11)
|
chain |
A |
residue |
157 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN A 2001
|
source |
: AC2
|
|
12)
|
chain |
B |
residue |
1095 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN B 2000
|
source |
: AC3
|
|
13)
|
chain |
B |
residue |
1097 |
type |
|
sequence |
K
|
description |
BINDING SITE FOR RESIDUE ZN B 2000
|
source |
: AC3
|
|
14)
|
chain |
B |
residue |
1098 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN B 2000
|
source |
: AC3
|
|
15)
|
chain |
B |
residue |
1107 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN B 2000
|
source |
: AC3
|
|
16)
|
chain |
B |
residue |
1110 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN B 2000
|
source |
: AC3
|
|
17)
|
chain |
I |
residue |
5 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN I 2000
|
source |
: AC4
|
|
18)
|
chain |
I |
residue |
8 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN I 2000
|
source |
: AC4
|
|
19)
|
chain |
I |
residue |
26 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN I 2000
|
source |
: AC4
|
|
20)
|
chain |
I |
residue |
29 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN I 2000
|
source |
: AC4
|
|
21)
|
chain |
J |
residue |
7 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN J 2000
|
source |
: AC5
|
|
22)
|
chain |
J |
residue |
10 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN J 2000
|
source |
: AC5
|
|
23)
|
chain |
J |
residue |
45 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN J 2000
|
source |
: AC5
|
|
24)
|
chain |
J |
residue |
46 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN J 2000
|
source |
: AC5
|
|
25)
|
chain |
L |
residue |
31 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN L 2000
|
source |
: AC6
|
|
26)
|
chain |
L |
residue |
34 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN L 2000
|
source |
: AC6
|
|
27)
|
chain |
L |
residue |
48 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN L 2000
|
source |
: AC6
|
|
28)
|
chain |
L |
residue |
51 |
type |
|
sequence |
C
|
description |
BINDING SITE FOR RESIDUE ZN L 2000
|
source |
: AC6
|
|
29)
|
chain |
C |
residue |
65-105 |
type |
prosite |
sequence |
NAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLV
P
|
description |
RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NAFRRimisevpsvAaeyVyffnNtSviqDEvLAhRIGLVP
|
source |
prosite : PS00446
|
|
30)
|
chain |
I |
residue |
4-29 |
type |
prosite |
sequence |
FCPSCNNMLLITSGDSGVYTLACRSC
|
description |
RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCPSCNNMLlitsgdsgvytla.CrsC
|
source |
prosite : PS01030
|
|
31)
|
chain |
E |
residue |
147-160 |
type |
prosite |
sequence |
HELVPKHIRLSSDE
|
description |
RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPKHirLssDE
|
source |
prosite : PS01110
|
|
32)
|
chain |
F |
residue |
86-100 |
type |
prosite |
sequence |
TKYERARILGTRALQ
|
description |
RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARiLGtRAlQ
|
source |
prosite : PS01111
|
|
33)
|
chain |
J |
residue |
2-11 |
type |
prosite |
sequence |
IVPVRCFSCG
|
description |
RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IVPVrCFSCG
|
source |
prosite : PS01112
|
|
34)
|
chain |
K |
residue |
65-96 |
type |
prosite |
sequence |
IVEEDHTLGNALRYVIMKNPDVEFCGYSIPHP
|
description |
RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. IveEdHTLgNaLryvImknpdVefcgYsipHP
|
source |
prosite : PS01154
|
|
35)
|
chain |
B |
residue |
909-921 |
type |
prosite |
sequence |
GDKFSSRHGQKGV
|
description |
RNA_POL_BETA RNA polymerases beta chain signature. GdKFSSrHGQKGV
|
source |
prosite : PS01166
|
|
36)
|
chain |
A |
residue |
515 |
type |
MOD_RES |
sequence |
D
|
description |
Phosphothreonine => ECO:0007744|PubMed:18407956
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
37)
|
chain |
J |
residue |
45 |
type |
MOD_RES |
sequence |
C
|
description |
Phosphothreonine => ECO:0007744|PubMed:18407956
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
38)
|
chain |
J |
residue |
46 |
type |
MOD_RES |
sequence |
C
|
description |
Phosphothreonine => ECO:0007744|PubMed:18407956
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
39)
|
chain |
A |
residue |
107 |
type |
MOD_RES |
sequence |
C
|
description |
Phosphothreonine => ECO:0007744|PubMed:18407956
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
40)
|
chain |
A |
residue |
110 |
type |
MOD_RES |
sequence |
C
|
description |
Phosphothreonine => ECO:0007744|PubMed:18407956
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
41)
|
chain |
A |
residue |
154 |
type |
MOD_RES |
sequence |
C
|
description |
Phosphothreonine => ECO:0007744|PubMed:18407956
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
42)
|
chain |
A |
residue |
511 |
type |
MOD_RES |
sequence |
D
|
description |
Phosphothreonine => ECO:0007744|PubMed:18407956
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
43)
|
chain |
A |
residue |
513 |
type |
MOD_RES |
sequence |
D
|
description |
Phosphothreonine => ECO:0007744|PubMed:18407956
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
44)
|
chain |
L |
residue |
48 |
type |
MOD_RES |
sequence |
C
|
description |
Phosphoserine => ECO:0007744|PubMed:19779198
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
45)
|
chain |
L |
residue |
51 |
type |
MOD_RES |
sequence |
C
|
description |
Phosphoserine => ECO:0007744|PubMed:19779198
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
46)
|
chain |
I |
residue |
8 |
type |
MOD_RES |
sequence |
C
|
description |
Phosphoserine => ECO:0007744|PubMed:17287358
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
47)
|
chain |
I |
residue |
26 |
type |
MOD_RES |
sequence |
C
|
description |
Phosphoserine => ECO:0007744|PubMed:17287358
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
48)
|
chain |
I |
residue |
29 |
type |
MOD_RES |
sequence |
C
|
description |
Phosphoserine => ECO:0007744|PubMed:17287358
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
49)
|
chain |
I |
residue |
100 |
type |
MOD_RES |
sequence |
C
|
description |
Phosphothreonine => ECO:0007744|PubMed:17287358, ECO:0007744|PubMed:17330950
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
50)
|
chain |
I |
residue |
103 |
type |
MOD_RES |
sequence |
C
|
description |
Phosphothreonine => ECO:0007744|PubMed:17287358, ECO:0007744|PubMed:17330950
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source |
Swiss-Prot : SWS_FT_FI4
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