|
|
eF-site ID
|
5fgk-B |
|
PDB Code
|
5fgk |
|
Chain
|
B |
|
click to enlarge
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Title
|
CDK8-CYCC IN COMPLEX WITH 8-[3-(3-Amino-1H-indazol-6-yl)-5-chloro- pyridine-4-yl]-2,8-diaza-spiro[4.5]decan-1-one |
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Classification
|
TRANSFERASE |
|
Compound
|
Cyclin-dependent kinase 8 |
|
Source
|
null (CCNC_HUMAN) |
|
|
Sequence
|
B: |
KAMAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYW
KLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSL
KSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKT
RFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRP
LLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIA
LACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLY
EQWKNFDERKEMATILSKMPKPKPPP
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|
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Description
|
(1) |
Cyclin-dependent kinase 8 (E.C.2.7.11.22,2.7.11.23), Cyclin-C
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
41 |
| type |
|
| sequence |
Q
|
| description |
binding site for residue FMT B 301
|
| source |
: AD2
|
|
|
2)
|
chain |
B |
| residue |
45 |
| type |
|
| sequence |
T
|
| description |
binding site for residue FMT B 301
|
| source |
: AD2
|
|
|
3)
|
chain |
B |
| residue |
66 |
| type |
|
| sequence |
T
|
| description |
binding site for residue FMT B 301
|
| source |
: AD2
|
|
|
4)
|
chain |
B |
| residue |
69 |
| type |
|
| sequence |
F
|
| description |
binding site for residue FMT B 301
|
| source |
: AD2
|
|
|
5)
|
chain |
B |
| residue |
70 |
| type |
|
| sequence |
K
|
| description |
binding site for residue FMT B 301
|
| source |
: AD2
|
|
|
6)
|
chain |
B |
| residue |
184 |
| type |
|
| sequence |
Y
|
| description |
binding site for residue FMT B 301
|
| source |
: AD2
|
|
|
|